Mycobacterium tuberculosis alters the metalloprotease activity of the COP9 signalosome.

abstract：UNLABELLED:Enoyl-acyl carrier protein (enoyl-ACP) reductase catalyzes the last step of the elongation cycle in the synthesis of bacterial fatty acids. The Enterococcus faecalis genome contains two genes annotated as enoyl-ACP reductases, a FabI-type enoyl-ACP reductase and a FabK-type enoyl-ACP reductase. We report tha...

journal_title：mBio

authors： Zhu L,Bi H,Ma J,Hu Z,Zhang W,Cronan JE,Wang H

更新日期：2013-10-01 00:00:00

abstract：UNLABELLED:Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems. However, the structural specificity of these systems for sugar substrates has hindered their appl...

journal_title：mBio

authors： Pan C,Sun P,Liu B,Liang H,Peng Z,Dong Y,Wang D,Liu X,Wang B,Zeng M,Wu J,Zhu L,Wang H

更新日期：2016-04-26 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic of chlamydial infection is the propensity to cause persistent in...

journal_title：mBio

authors： Yang C,Kari L,Lei L,Carlson JH,Ma L,Couch CE,Whitmire WM,Bock K,Moore I,Bonner C,McClarty G,Caldwell HD

更新日期：2020-08-18 00:00:00

abstract：UNLABELLED:Heteroresistance refers to phenotypic heterogeneity of microbial clonal populations under antibiotic stress, and it has been thought to be an allocation of a subset of "resistant" cells for surviving in higher concentrations of antibiotic. The assumption fits the so-called bet-hedging strategy, where a bacte...

journal_title：mBio

authors： Wang X,Kang Y,Luo C,Zhao T,Liu L,Jiang X,Fu R,An S,Chen J,Jiang N,Ren L,Wang Q,Baillie JK,Gao Z,Yu J

更新日期：2014-02-11 00:00:00

abstract：:Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence. The role of cyclic diguanylate signaling in the lifestyle of Legionella pne...

journal_title：mBio

authors： Levi A,Folcher M,Jenal U,Shuman HA

更新日期：2011-01-11 00:00:00

abstract：:A simple method for filtering water to reduce the incidence of cholera was tested in a field trial in Matlab, Bangladesh, and proved effective. A follow-up study was conducted 5 years later to determine whether the filtration method continued to be employed by villagers and its impact on the incidence of cholera. A to...

journal_title：mBio

authors： Huq A,Yunus M,Sohel SS,Bhuiya A,Emch M,Luby SP,Russek-Cohen E,Nair GB,Sack RB,Colwell RR

更新日期：2010-05-18 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of lim...

journal_title：mBio

authors： Ausiello CM,Cassone A

更新日期：2014-06-10 00:00:00

abstract：UNLABELLED:Pseudomonas aeruginosa is a common cause of infection in the lungs of patients with cystic fibrosis (CF). In addition, biofilm formation and antibiotic resistance of Pseudomonas are major problems that can complicate antibiotic therapy. We evaluated the efficacy of using bacteriophages to kill the pathogen i...

journal_title：mBio

authors： Alemayehu D,Casey PG,McAuliffe O,Guinane CM,Martin JG,Shanahan F,Coffey A,Ross RP,Hill C

更新日期：2012-03-06 00:00:00

abstract：UNLABELLED:The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe respiratory infection with a high mortality rate (~35%). MERS-CoV has been a global threat due to continuous outbreaks in the Arabian peninsula and international spread by infected travelers since 2012. From May to Jul...

journal_title：mBio

authors： Kim Y,Cheon S,Min CK,Sohn KM,Kang YJ,Cha YJ,Kang JI,Han SK,Ha NY,Kim G,Aigerim A,Shin HM,Choi MS,Kim S,Cho HS,Kim YS,Cho NH

更新日期：2016-03-01 00:00:00

abstract：:Symbiotic microorganisms can have a profound impact on the host physiology and behavior, and novel relationships between symbionts and their hosts are continually discovered. A colony of social ants consists of various castes that exhibit distinct lifestyles and is, thus, a unique model for investigating how symbionts...

journal_title：mBio

authors： Koto A,Nobu MK,Miyazaki R

更新日期：2020-04-21 00:00:00

abstract：:Vibrio vulnificus, an opportunistic pathogen, is the causative agent of a life-threatening septicemia and a rising problem for aquaculture worldwide. The genetic factors that differentiate its clinical and environmental strains remain enigmatic. Furthermore, clinical strains have emerged from every clade of V. vulnifi...

journal_title：mBio

authors： López-Pérez M,Jayakumar JM,Haro-Moreno JM,Zaragoza-Solas A,Reddi G,Rodriguez-Valera F,Shapiro OH,Alam M,Almagro-Moreno S

更新日期：2019-02-19 00:00:00

abstract：UNLABELLED:Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate of protection. However, recent poor vaccine performance ...

journal_title：mBio

authors： Memoli MJ,Shaw PA,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Fargis S,Risos K,Powers JH,Davey RT Jr,Taubenberger JK

更新日期：2016-04-19 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma (KS), caused by KS-associated herpesvirus (KSHV), is the most common cancer among HIV-infected patients in Malawi and in the United States today. In Malawi, KSHV is endemic. We conducted a cross-sectional study of patients with HIV infection and KS with no history of chemo- or antiretroviral...

journal_title：mBio

authors： Hosseinipour MC,Sweet KM,Xiong J,Namarika D,Mwafongo A,Nyirenda M,Chiwoko L,Kamwendo D,Hoffman I,Lee J,Phiri S,Vahrson W,Damania B,Dittmer DP

更新日期：2014-09-23 00:00:00

abstract：UNLABELLED:Human cathepsin W (CtsW) is a cysteine protease, which was identified in a genome-wide RNA interference (RNAi) screen to be required for influenza A virus (IAV) replication. In this study, we show that reducing the levels of expression of CtsW reduces viral titers for different subtypes of IAV, and we map th...

journal_title：mBio

authors： Edinger TO,Pohl MO,Yángüez E,Stertz S

更新日期：2015-06-09 00:00:00

abstract：UNLABELLED:A mechanistic understanding of the determination and maintenance of the simplest bacterial cell shape, a sphere, remains elusive compared with that of more complex shapes. Cocci seem to lack a dedicated elongation machinery, and a spherical shape has been considered an evolutionary dead-end morphology, as a ...

journal_title：mBio

authors： Pereira AR,Hsin J,Król E,Tavares AC,Flores P,Hoiczyk E,Ng N,Dajkovic A,Brun YV,VanNieuwenhze MS,Roemer T,Carballido-Lopez R,Scheffers DJ,Huang KC,Pinho MG

更新日期：2016-09-06 00:00:00

abstract：:RNA-binding proteins (RBPs) play a major role during control of mRNA localization, stability, and translation and are central to most cellular processes. In the fission yeast Schizosaccharomyces pombe, the multiple K homology (KH) domain RBP Rnc1 downregulates the activity of the cell integrity pathway (CIP) via stabi...

journal_title：mBio

authors： Prieto-Ruiz F,Vicente-Soler J,Franco A,Gómez-Gil E,Sánchez-Marinas M,Vázquez-Marín B,Aligué R,Madrid M,Moreno S,Soto T,Cansado J

更新日期：2020-01-07 00:00:00

abstract：:Diet influences health in multiple ways. One important effect of diet is on the gut microbiota. The effects of diet are often related to an individual's specific microbiota composition. The close links between health, diet, and gut microbiota are illustrated in a new mouse model of sepsis where the combination of a hi...

journal_title：mBio

authors： Bassis CM

更新日期：2019-10-08 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whether the enzyme plays a prote...

journal_title：mBio

authors： Costa DL,Namasivayam S,Amaral EP,Arora K,Chao A,Mittereder LR,Maiga M,Boshoff HI,Barry CE 3rd,Goulding CW,Andrade BB,Sher A

更新日期：2016-10-25 00:00:00

abstract：UNLABELLED:Moraxella catarrhalis is a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step in M. catarrhalis colonization is adherence to the mucosa, epithelial cells, and extrac...

journal_title：mBio

authors： Singh B,Alvarado-Kristensson M,Johansson M,Hallgren O,Westergren-Thorsson G,Mörgelin M,Riesbeck K

更新日期：2016-03-22 00:00:00

abstract：:The β-barrel assembly machinery, the Bam complex, is central to the biogenesis of integral outer membrane proteins (OMPs) as well as OMP-dependent surface-exposed lipoproteins, such as regulator of capsule synthesis protein F (RcsF). Previous genetic analysis established the model that nonessential components BamE and...

journal_title：mBio

authors： Tata M,Konovalova A

更新日期：2019-05-21 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined. Nef interferes with host cell actin dynamics to restrict T lymphocyte responses to chemokine stimulation and T cell recept...

journal_title：mBio

authors： Imle A,Abraham L,Tsopoulidis N,Hoflack B,Saksela K,Fackler OT

更新日期：2015-09-08 00:00:00

abstract：UNLABELLED:In Staphylococcus aureus, hundreds of small regulatory or small RNAs (sRNAs) have been identified, yet this class of molecule remains poorly understood and severely understudied. sRNA genes are typically absent from genome annotation files, and as a consequence, their existence is often overlooked, particula...

journal_title：mBio

authors： Carroll RK,Weiss A,Broach WH,Wiemels RE,Mogen AB,Rice KC,Shaw LN

更新日期：2016-02-09 00:00:00

abstract：UNLABELLED:The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models such as mice and rabbits. Here we have taken advantage of a zebrafish model to investigate host-pathogen interactions of Cryptococcus w...

journal_title：mBio

authors： Tenor JL,Oehlers SH,Yang JL,Tobin DM,Perfect JR

更新日期：2015-09-29 00:00:00

abstract：:The development of vaccines is one of the greatest medical interventions in the history of global infectious diseases and has contributed to the annual saving of at least 2 to 3 million lives worldwide. However, many diseases are not preventable through currently available vaccines, and the potential of modulating the...

journal_title：mBio

authors： Domínguez-Andrés J,van Crevel R,Divangahi M,Netea MG

更新日期：2020-12-22 00:00:00

abstract：UNLABELLED:A 32-nucleotide (nt) RNA motif located at the 3' end of the transmissible gastroenteritis coronavirus (TGEV) genome was found to specifically interact with the host proteins glutamyl-prolyl-tRNA synthetase (EPRS) and arginyl-tRNA synthetase (RRS). This RNA motif has high homology in sequence and secondary st...

journal_title：mBio

authors： Marquez-Jurado S,Nogales A,Zuñiga S,Enjuanes L,Almazán F

更新日期：2015-03-10 00:00:00

abstract：UNLABELLED:As diet is considered the major regulator of the gut ecosystem, the overall objective of this work was to demonstrate that a detailed knowledge of the phytochemical composition of food could add to our understanding of observed changes in functionality and activity of the gut microbiota. We used metatranscri...

journal_title：mBio

authors： Ni Y,Li J,Panagiotou G

更新日期：2015-10-27 00:00:00

abstract：:Noncoding RNAs, including antisense RNAs (asRNAs) that originate from the complementary strand of protein-coding genes, are involved in the regulation of gene expression in all domains of life. Recent application of deep-sequencing technologies has revealed that the transcription of asRNAs occurs genome-wide in bacter...

journal_title：mBio

authors： Raghavan R,Sloan DB,Ochman H

更新日期：2012-08-07 00:00:00

abstract：:Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), also known as A20, is a ubiquitin-editing enzyme capable of ubiquitination or deubiquitination of its target proteins. In this study, we show that hepatitis C virus (HCV) infection could induce the expression of A20 via the activation of the A20 promoter. The in...

journal_title：mBio

authors： Lee J,Chan ST,Kim JY,Ou JJ

更新日期：2019-07-23 00:00:00

abstract：UNLABELLED:The human pathogen Streptococcus pneumoniae (pneumococcus) exhibits a high degree of genomic diversity and plasticity. Isolates with high genomic similarity are grouped into lineages that undergo homologous recombination at variable rates. PMEN1 is a pandemic, multidrug-resistant lineage. Heterologous gene e...

journal_title：mBio

authors： Eutsey RA,Powell E,Dordel J,Salter SJ,Clark TA,Korlach J,Ehrlich GD,Hiller NL

更新日期：2015-06-16 00:00:00