Leucine Biosynthesis Is Involved in Regulating High Lipid Accumulation in Yarrowia lipolytica.

abstract：UNLABELLED:Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited. Of the two major antifungal drug classes, azoles are active against C. neoformans but exert a fungistatic effect, necessitating long tr...

journal_title：mBio

authors： Huang W,Liao G,Baker GM,Wang Y,Lau R,Paderu P,Perlin DS,Xue C

更新日期：2016-05-10 00:00:00

abstract：:Adult Drosophila melanogaster raised in the absence of symbiotic bacteria have fewer intestinal stem cell divisions and a longer life span than their conventionally reared counterparts. However, we do not know if increased stem cell divisions are essential for symbiont-dependent regulation of longevity. To determine i...

journal_title：mBio

authors： Fast D,Duggal A,Foley E

更新日期：2018-07-31 00:00:00

abstract：UNLABELLED:The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens cause an increasing number of nosocomial infections worldwide since they escape the inhibitory effect of the available antibiotics and the immun...

journal_title：mBio

authors： Behroozian S,Svensson SL,Davies J

更新日期：2016-01-26 00:00:00

abstract：UNLABELLED:The protein YfeX from Escherichia coli has been proposed to be essential for the process of iron removal from heme by carrying out a dechelation of heme without cleavage of the porphyrin macrocycle. Since this proposed reaction is unique and would represent the first instance of the biological dechelation of...

journal_title：mBio

authors： Dailey HA,Septer AN,Daugherty L,Thames D,Gerdes S,Stabb EV,Dunn AK,Dailey TA,Phillips JD

更新日期：2011-11-08 00:00:00

abstract：:The members of the OM43 clade of Betaproteobacteria are abundant coastal methylotrophs with a range of carbon-utilizing capabilities. However, their underlying transcriptional and metabolic responses to shifting conditions or different carbon substrates remain poorly understood. We examined the transcriptional dynamic...

journal_title：mBio

authors： Gifford SM,Becker JW,Sosa OA,Repeta DJ,DeLong EF

更新日期：2016-11-22 00:00:00

abstract：UNLABELLED:A mechanistic understanding of the determination and maintenance of the simplest bacterial cell shape, a sphere, remains elusive compared with that of more complex shapes. Cocci seem to lack a dedicated elongation machinery, and a spherical shape has been considered an evolutionary dead-end morphology, as a ...

journal_title：mBio

authors： Pereira AR,Hsin J,Król E,Tavares AC,Flores P,Hoiczyk E,Ng N,Dajkovic A,Brun YV,VanNieuwenhze MS,Roemer T,Carballido-Lopez R,Scheffers DJ,Huang KC,Pinho MG

更新日期：2016-09-06 00:00:00

abstract：:Innate immune response plays a critical role in controlling invading pathogens, but such an immune response must be tightly regulated. Insufficient or overactivated immune responses may lead to harmful or even fatal consequences. To dissect the complex host-parasite interactions and the molecular mechanisms underlying...

journal_title：mBio

authors： Cai B,Wu J,Yu X,Su XZ,Wang RF

更新日期：2017-01-03 00:00:00

abstract：:Sinorhizobium meliloti is an alphaproteobacterium belonging to the Rhizobiales Bacteria from this order elongate their cell wall at the new cell pole, generated by cell division. Screening for protein interaction partners of the previously characterized polar growth factors RgsP and RgsM, we identified the inner membr...

journal_title：mBio

authors： Krol E,Yau HCL,Lechner M,Schäper S,Bange G,Vollmer W,Becker A

更新日期：2020-06-30 00:00:00

abstract：:Increasing evidence has indicated that single nucleotide polymorphisms (SNPs) are related to the susceptibility of sepsis and might provide potential evidence for the mechanisms of sepsis. Our recent preliminary study showed that the ADAM10 genetic polymorphism was clinically associated with the development of sepsis,...

journal_title：mBio

authors： Chen F,Wang Y,Zhang W,Cai Y,Zhao T,Mai H,Tao S,Wei W,Li J,Chen X,Li X,Tang P,Fan W,Yang J,Ou M,Lu F,Lai Z,Chen H,Zou T,Sun F,Shao Y,Cui L

更新日期：2019-08-06 00:00:00

abstract：:Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ), and acyl carrier protein (ACP), are utilized to elongate the p...

journal_title：mBio

authors： Hua K,Liu X,Zhao Y,Gao Y,Pan L,Zhang H,Deng Z,Jiang M

更新日期：2020-09-15 00:00:00

abstract：:The Mo- and V-nitrogenases are two homologous members of the nitrogenase family that are distinguished mainly by the presence of different heterometals (Mo or V) at their respective cofactor sites (M- or V-cluster). However, the V-nitrogenase is ~600-fold more active than its Mo counterpart in reducing CO to hydrocarb...

journal_title：mBio

authors： Rebelein JG,Lee CC,Newcomb M,Hu Y,Ribbe MW

更新日期：2018-03-13 00:00:00

abstract：:Emerging zoonotic viral diseases remain a challenge to global public health. Recent surveillance studies have implicated bats as potential reservoirs for a number of viral pathogens, including coronaviruses and Ebola viruses. Caliciviridae represent a major viral family contributing to emerging diseases in both human ...

journal_title：mBio

authors： Kocher JF,Lindesmith LC,Debbink K,Beall A,Mallory ML,Yount BL,Graham RL,Huynh J,Gates JE,Donaldson EF,Baric RS

更新日期：2018-05-22 00:00:00

abstract：:Colicins are toxins produced and released by Enterobacteriaceae to kill competitors in the gut. While group A colicins employ a division of labor strategy to liberate the toxin into the environment via colicin-specific lysis, group B colicin systems lack cognate lysis genes. In Salmonella enterica serovar Typhimurium ...

journal_title：mBio

authors： Spriewald S,Stadler E,Hense BA,Münch PC,McHardy AC,Weiss AS,Obeng N,Müller J,Stecher B

更新日期：2020-07-21 00:00:00

abstract：:Since the original report that Halomonas sp. strain GFAJ-1 was capable of using arsenic instead of phosphorus to sustain growth, additional studies have been conducted, and GFAJ-1 is now considered a highly arsenic-resistant but phosphorus-dependent bacterium. However, the mechanisms supporting the extreme arsenic res...

journal_title：mBio

authors： Wu S,Wang L,Gan R,Tong T,Bian H,Li Z,Du S,Deng Z,Chen S

更新日期：2018-05-01 00:00:00

abstract：:Staphylococcus aureus is intrinsically resistant to polymyxins (polymyxin B and colistin), an important class of cationic antimicrobial peptides used in treatment of Gram-negative bacterial infections. To understand the mechanisms underlying intrinsic polymyxin resistance in S. aureus, we screened the Nebraska Transpo...

journal_title：mBio

authors： Vestergaard M,Nøhr-Meldgaard K,Bojer MS,Krogsgård Nielsen C,Meyer RL,Slavetinsky C,Peschel A,Ingmer H

更新日期：2017-09-05 00:00:00

abstract：:Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which concentrate all the proteins of the polymerase complex as well as some cellular proteins, were initially considered aggresomes formed by viral dead...

journal_title：mBio

authors： Galloux M,Risso-Ballester J,Richard CA,Fix J,Rameix-Welti MA,Eléouët JF

更新日期：2020-09-22 00:00:00

abstract：:Nonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages an...

journal_title：mBio

authors： Frazão SO,Sousa HR,Silva LGD,Folha JDS,Gorgonha KCM,Oliveira GP Jr,Felipe MSS,Silva-Pereira I,Casadevall A,Nicola AM,Albuquerque P

更新日期：2020-09-08 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. P. aeruginosa infections are difficult to treat due to a number of antibiotic resistance mechanisms and the organism's propensity to form multicellular biofilms. Epidemic strains of P....

journal_title：mBio

authors： Oluyombo O,Penfold CN,Diggle SP

更新日期：2019-01-29 00:00:00

abstract：UNLABELLED:The only tuberculosis (TB) vaccine in use today, bacillus Calmette-Guérin (BCG), provides insufficient protection and can cause adverse events in immunocompromised individuals, such as BCGosis in HIV(+) newborns. We previously reported improved preclinical efficacy and safety of the recombinant vaccine candi...

journal_title：mBio

authors： Gengenbacher M,Vogelzang A,Schuerer S,Lazar D,Kaiser P,Kaufmann SH

更新日期：2014-06-03 00:00:00

abstract：UNLABELLED:Protein-protein interactions are important for virtually every biological process, and a number of elegant approaches have been designed to detect and evaluate such interactions. However, few of these methods allow the detection of dynamic and real-time protein-protein interactions in bacteria. Here we descr...

journal_title：mBio

authors： Cui B,Wang Y,Song Y,Wang T,Li C,Wei Y,Luo ZQ,Shen X

更新日期：2014-05-20 00:00:00

abstract：UNLABELLED:Investigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial inhabitant, Propionibacterium acnes, which is thought to contribute to th...

journal_title：mBio

authors： Marinelli LJ,Fitz-Gibbon S,Hayes C,Bowman C,Inkeles M,Loncaric A,Russell DA,Jacobs-Sera D,Cokus S,Pellegrini M,Kim J,Miller JF,Hatfull GF,Modlin RL

更新日期：2012-09-25 00:00:00

abstract：:With great apprehension, the world is now watching the birth of a novel pandemic already causing tremendous suffering, death, and disruption of normal life. Uncertainty and dread are exacerbated by the belief that what we are experiencing is new and mysterious. However, deadly pandemics and disease emergences are not ...

journal_title：mBio

authors： Morens DM,Daszak P,Markel H,Taubenberger JK

更新日期：2020-05-29 00:00:00

abstract：:Unlike all other archaeal lineages, ammonia-oxidizing archaea (AOA) of the phylum Thaumarchaeota are widespread and abundant in all moderate and oxic environments on Earth. The evolutionary adaptations that led to such unprecedented ecological success of a microbial clade characterized by highly conserved energy and c...

journal_title：mBio

authors： Abby SS,Kerou M,Schleper C

更新日期：2020-10-13 00:00:00

abstract：:The pathogenic species of Cryptococcus are a major cause of mortality owing to severe infections in immunocompromised as well as immunocompetent individuals. Although antifungal treatment is usually effective, many patients relapse after treatment, and in such cases, comparative analyses of the genomes of incident and...

journal_title：mBio

authors： Chen Y,Farrer RA,Giamberardino C,Sakthikumar S,Jones A,Yang T,Tenor JL,Wagih O,Van Wyk M,Govender NP,Mitchell TG,Litvintseva AP,Cuomo CA,Perfect JR

更新日期：2017-03-07 00:00:00

abstract：:Interferons (IFNs) and autophagy are critical neuronal defenses against viral infection. IFNs alter neuronal autophagy by promoting the accumulation of IFN-dependent LC3-decorated autophagic structures, termed LC3 clusters. Here, we analyzed LC3 clusters in sensory ganglia following herpes simplex virus 1 (HSV-1) infe...

journal_title：mBio

authors： Cabrera JR,Manivanh R,North BJ,Leib DA

更新日期：2019-03-05 00:00:00

abstract：UNLABELLED:Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms. The LuxR family of QS transcription factors regulates gene expression, coordinating population behavior by sensing endogenous acyl homoserine lactones (AHLs). However,...

journal_title：mBio

authors： Nguyen Y,Nguyen NX,Rogers JL,Liao J,MacMillan JB,Jiang Y,Sperandio V

更新日期：2015-03-31 00:00:00

abstract：:Pseudomonas aeruginosa, known as one of the leading causes of disease in cystic fibrosis (CF) patients, secretes a variety of proteases. These enzymes contribute significantly to P. aeruginosa pathogenesis and biofilm formation in the chronic colonization of CF patient lungs, as well as playing a role in infections of...

journal_title：mBio

authors： Esoda CN,Kuehn MJ

更新日期：2019-11-19 00:00:00

abstract：UNLABELLED:Mammalian lipopolysaccharide (LPS) binding proteins (LBPs) occur mainly in extracellular fluids and promote LPS delivery to specific host cell receptors. The function of LBPs has been studied principally in the context of host defense; the possible role of LBPs in nonpathogenic host-microbe interactions has ...

journal_title：mBio

authors： Krasity BC,Troll JV,Lehnert EM,Hackett KT,Dillard JP,Apicella MA,Goldman WE,Weiss JP,McFall-Ngai MJ

更新日期：2015-10-13 00:00:00

abstract：UNLABELLED:Antibiotics are a cost-effective tool for improving feed efficiency and preventing disease in agricultural animals, but the full scope of their collateral effects is not understood. Antibiotics have been shown to mediate gene transfer by inducing prophages in certain bacterial strains; therefore, one collate...

journal_title：mBio

authors： Allen HK,Looft T,Bayles DO,Humphrey S,Levine UY,Alt D,Stanton TB

更新日期：2011-11-29 00:00:00

abstract：:The disease mechanisms associated with the onset of astrovirus diarrhea are unknown. Unlike other enteric virus infections, astrovirus infection is not associated with an inflammatory response or cellular damage. In vitro studies in differentiated Caco-2 cells demonstrated that human astrovirus serotype 1 (HAstV-1) ca...

journal_title：mBio

authors： Meliopoulos VA,Marvin SA,Freiden P,Moser LA,Nighot P,Ali R,Blikslager A,Reddivari M,Heath RJ,Koci MD,Schultz-Cherry S

更新日期：2016-11-01 00:00:00