Abstract:
:A simple mathematical model of drug-induced plasmid elimination (curing) considering density-dependent growth rates and plasmid transfers is presented. It describes nonlinear population dynamics of conjugative plasmids during in vitro curing experiments in batch culture. The model was tested on kinetics of acridine orange curing of F'lac plasmid. Effects of density dependence, plasmid elimination, selection for plasmidless segregants, conjugation, initial and maximal population density, and postsegregational killing on curing kinetics are simulated and discussed.
journal_name
Plasmidjournal_title
Plasmidauthors
Sýkora P,Foltýnova Z,Smitálova Kdoi
10.1016/0147-619x(89)90052-8subject
Has Abstractpub_date
1989-03-01 00:00:00pages
85-98issue
2eissn
0147-619Xissn
1095-9890journal_volume
21pub_type
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