Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction.

Abstract:

:Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains proliferation, opposes cell death and regulates differentiation. Through integrins, cells perceive both the chemical composition and physical properties of the ECM. In particular, cell behaviour is profoundly influenced by the mechanical elasticity or stiffness of the ECM, which regulates the ability of cells to develop forces through their contractile actomyosin cytoskeleton and to mature focal adhesions. This mechanosensing ability affects fundamental cellular functions, such that alterations of ECM stiffness is nowadays considered not a simple consequence of pathology, but a causative input driving aberrant cell behaviours. We here discuss recent advances on how mechanical signals intersect nuclear transcription and in particular the activity of YAP/TAZ transcriptional coactivators, known downstream transducers of the Hippo pathway and important effectors of ECM mechanical cues.

journal_name

Exp Cell Res

authors

Dupont S

doi

10.1016/j.yexcr.2015.10.034

subject

Has Abstract

pub_date

2016-04-10 00:00:00

pages

42-53

issue

1

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(15)30139-7

journal_volume

343

pub_type

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