Abstract:
:Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains proliferation, opposes cell death and regulates differentiation. Through integrins, cells perceive both the chemical composition and physical properties of the ECM. In particular, cell behaviour is profoundly influenced by the mechanical elasticity or stiffness of the ECM, which regulates the ability of cells to develop forces through their contractile actomyosin cytoskeleton and to mature focal adhesions. This mechanosensing ability affects fundamental cellular functions, such that alterations of ECM stiffness is nowadays considered not a simple consequence of pathology, but a causative input driving aberrant cell behaviours. We here discuss recent advances on how mechanical signals intersect nuclear transcription and in particular the activity of YAP/TAZ transcriptional coactivators, known downstream transducers of the Hippo pathway and important effectors of ECM mechanical cues.
journal_name
Exp Cell Resjournal_title
Experimental cell researchauthors
Dupont Sdoi
10.1016/j.yexcr.2015.10.034subject
Has Abstractpub_date
2016-04-10 00:00:00pages
42-53issue
1eissn
0014-4827issn
1090-2422pii
S0014-4827(15)30139-7journal_volume
343pub_type
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