Abstract：
:Two amantadine (ATD)-gardenamide A (GA) ligands have been designed and synthesized. The bonding of ATD with GA through a methylene carbonyl brigde (L1) enhances the neuroprotective effect against corticosterone (CORT)-induced impairments in PC12 cells; while the bonding through a succinyl brigde (L2) does not. L1 reduces the level of reactive oxygen species (ROS) and cell apoptosis generated by CORT. It restores CORT-changed cell morphology to a state that is closed to normal PC12 cells. One mechanism of L1 to attenuate CORT-induced cell apoptosis is through the adjustment of both caspase-3 and Bcl-2 proteins. Like GA, both nNOS and eNOS might be involved in the neuroprotective mechanism of L1. All the evidences suggest that L1 may be a potential agent to treat depression.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zhao J,Peng L,Zheng W,Wang R,Zhang L,Yang J,Chen Hdoi
10.3390/ijms160922795subject
Has Abstractpub_date
2015-09-21 00:00:00pages
22795-810issue
9issn
1422-0067pii
ijms160922795journal_volume
16pub_type
杂志文章abstract：:Aqueous solutions of isovaline and its precursor molecule, 5-ethyl-5-methylhydantoin, were irradiated with ultraviolet and γ-ray photons, to evaluate their structural stability against space radiation. The degree of photolysis was measured and irradiation products were identified using chiral, reversed-phase and ion-e...
journal_title：International journal of molecular sciences
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更新日期：2017-02-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,随机对照试验
doi：10.3390/ijms161024475
更新日期：2015-10-15 00:00:00
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更新日期：2018-05-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2015-08-03 00:00:00
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journal_title：International journal of molecular sciences
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