Abstract:
:Fibrotic disease, which is implicated in almost half of all deaths worldwide, is the result of an uncontrolled wound healing response to injury in which tissue is replaced by deposition of excess extracellular matrix, leading to fibrosis and loss of organ function. A plethora of genome-wide association studies, microarrays, exome sequencing studies, DNA methylation arrays, next-generation sequencing, and profiling of noncoding RNAs have been performed in patient-derived fibrotic tissue, with the shared goal of utilizing genomics to identify the transcriptional networks and biological pathways underlying the development of fibrotic diseases. In this review, we discuss fibrosing disorders of the skin, liver, kidney, lung, and heart, systematically (1) characterizing the initial acute injury that drives unresolved inflammation, (2) identifying genomic studies that have defined the pathologic gene changes leading to excess matrix deposition and fibrogenesis, and (3) summarizing therapies targeting pro-fibrotic genes and networks identified in the genomic studies. Ultimately, successful bench-to-bedside translation of observations from genomic studies will result in the development of novel anti-fibrotic therapeutics that improve functional quality of life for patients and decrease mortality from fibrotic diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Stone RC,Chen V,Burgess J,Pannu S,Tomic-Canic Mdoi
10.3390/ijms21228590subject
Has Abstractpub_date
2020-11-14 00:00:00issue
22issn
1422-0067pii
ijms21228590journal_volume
21pub_type
杂志文章,评审abstract::MTH1 (MutT homolog 1) or NUDT1 (Nudix Hydrolase 1), also known as oxidized purine nucleoside triphosphatase, has potential as a biomarker for monitoring cancer progression and quantifying target engagement for relevant therapies. In this study, we validate one MTH1 inhibitor TH287 as a PET MTH1 radiotracer. TH287 was ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228860
更新日期:2020-11-23 00:00:00
abstract::In addition to the well-known diterpenoid steviol glycosides, Stevia rebaudiana (Stevia) produces many labdane-type diterpenoids and a wide range of mono- and sesquiterpenoids. However, biosynthesis of mono- and sesquiterpenoids in Stevia remains unknown. Here we analyzed the extracts of Stevia leaves, flowers, stems,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228566
更新日期:2020-11-13 00:00:00
abstract::Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used after transurethral res...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17071125
更新日期:2016-07-14 00:00:00
abstract::Blood vessels in vertebrates are established and genetically controlled in an evolutionarily-conserved manner during embryogenesis. Disruption of vascular growth by chemical compounds or environmental hormones may cause developmental defects. This study analyzed the vascular impacts of marine compound GB9 in zebrafish...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18081696
更新日期:2017-08-03 00:00:00
abstract::Twenty-one microsatellite markers from the genome of Cardiocrinum giganteum var. yunnanense, an important economic plant in China, were developed with a fast isolation protocol by amplified fragment length polymorphism of sequences containing repeats (FIASCO). Polymorphism within each locus was assessed in 24 wild ind...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13021437
更新日期:2012-01-01 00:00:00
abstract::Chlorotoxin (CTX) is a 36⁻amino acid peptide with eight Cys residues that forms four disulfide bonds. It has high affinity for the glioma-specific chloride channel and matrix metalloprotease-2. Structural and binding properties of CTX analogs with various Cys residue substitutions with l-α-aminobutyric acid (Abu) have...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20061261
更新日期:2019-03-13 00:00:00
abstract::Although radiotherapy is generally effective in the treatment of major nasopharyngeal carcinoma (NPC), this treatment still makes approximately 20% of patients radioresistant. Therefore, the identification of blood or biopsy biomarkers that can predict the treatment response to radioresistance and that can diagnosis e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms160715497
更新日期:2015-07-08 00:00:00
abstract::Self-assembling peptides have been employed as biotemplates for biomineralization, as the morphologies and sizes of the inorganic materials can be easily controlled. We synthesized two types of highly ordered self-assembling peptides with different secondary structures and investigated the effects of secondary structu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184650
更新日期:2019-09-19 00:00:00
abstract::Remote ischemic conditioning (RIC) confers cardioprotection in patients with ST-segment elevation myocardial infarction (STEMI). Despite intense research, the translation of RIC into clinical practice remains a challenge. This may, at least partly, be due to confounding factors that may modify the efficacy of RIC. The...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20133246
更新日期:2019-07-02 00:00:00
abstract::In healthy individuals, the healing of soft tissues such as skin after pathological insult or post injury follows a relatively predictable and defined series of cell and molecular processes to restore tissue architecture and function(s). Healing progresses through the phases of hemostasis, inflammation, proliferation,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21031015
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:Endothelial progenitor cells (EPCs) were indicated in vascular repair, angiogenesis of ischemic organs, and inhibition of formation of initial hyperplasia. Differentiation of endothelial cells (ECs) from human induced pluripotent stem cells (hiPSC)-derived endothelial cells (hiPSC-ECs) provides an unlimited ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20143536
更新日期:2019-07-19 00:00:00
abstract::We herein investigated the detection frequency and clinical relevance of circulating tumor cells (CTCs) in chemotherapy-naïve stage IIIB/IV non-small cell lung cancer (NSCLC), by using the CellSearch and real-time CEACAM5mRNA assays. Blood samples from 43 patients were obtained at different time points during first-li...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020925
更新日期:2021-01-18 00:00:00
abstract::Burn-induced heart dysfunction is a key factor for patient mortality. However, the molecular mechanisms are not yet fully elucidated. This study sought to understand whether burn-induced heart dysfunction is associated with cardiac mitochondrial dysfunction and interruption of the PDE5A-cGMP-PKG pathway. Sixty percent...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072350
更新日期:2020-03-28 00:00:00
abstract::The insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2) is an oncogenic protein known to be overexpressed in different tumor types. Pancreatic cancer is a very lethal cancer that requires early diagnosis and new treatment options. The aim of our study was to investigate the role of IMP2 in the init...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20133204
更新日期:2019-06-29 00:00:00
abstract::Neurodegenerative diseases may have distinct genetic etiologies and pathological manifestations, yet share common cellular mechanisms underpinning neuronal damage and dysfunction. These cellular mechanisms include excitotoxicity, calcium dysregulation, oxidative damage, ER stress and neuroinflammation. Recent data hav...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17081332
更新日期:2016-08-12 00:00:00
abstract::Iron is an essential element for the growth and proliferation of cells. Cellular iron uptake, storage, utilization and export are tightly regulated to maintain iron homeostasis. However, cellular iron metabolism pathways are disturbed in most cancer cells. To maintain rapid growth and proliferation, cancer cells acqui...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19051545
更新日期:2018-05-22 00:00:00
abstract::Molecular etiology of thyroid cancers has been widely studied, and several molecular alterations have been identified mainly associated with follicular and papillary histotypes. However, the molecular bases of the complex pathogenesis of thyroid carcinomas remain poorly understood. HOX genes regulate normal embryonic ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141121727
更新日期:2013-11-01 00:00:00
abstract::The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells was investigated. The enrichment of mast cells with different PUFA including α-linolenic acid (LNA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), linoleic acid (LA) or arachidonic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14059005
更新日期:2013-04-25 00:00:00
abstract::The role of astrocytes in the glioblastoma (GBM) microenvironment is poorly understood; particularly with regard to cell invasion and drug resistance. To assess this role of astrocytes in GBMs we established an all human 2D co-culture model and a 3D hyaluronic acid-gelatin based hydrogel model (HyStem™-HP) with differ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20236017
更新日期:2019-11-29 00:00:00
abstract::The Global Burden of Disease Study identified cardiovascular risk factors as leading causes of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism that is associated with most of these risk factors and stressors, and represents an early (subclinical) marker/predictor of atheroscleros...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20010187
更新日期:2019-01-07 00:00:00
abstract::In the endoplasmic reticulum (ER), misfolded and unfolded proteins are eliminated by a process called ER-associated protein degradation (ERAD) in order to maintain cell homeostasis. In the ERAD pathway, several ER-localized E3 ubiquitin ligases target ERAD substrate proteins for ubiquitination and subsequent proteasom...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17111829
更新日期:2016-11-02 00:00:00
abstract::In allergic bronchial asthma, an increased smooth muscle contractility of the airways is one of the causes of the airway hyperresponsiveness (AHR). Increasing evidence also suggests a possible involvement of microRNAs (miRNAs) in airway diseases, including asthma, although their roles in function and pathology largely...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21217982
更新日期:2020-10-27 00:00:00
abstract::This narrative review aims to summarize the current controversy on the balance between ethanol and phytochemicals in wine, focusing on light drinking and oral cancer. Extensive literature search included PUBMED and EMBASE databases to identify in human studies and systematic reviews (up to March 2015), which contribut...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms160817029
更新日期:2015-07-27 00:00:00
abstract::Ischemia-reperfusion injury (IRI) is a major cause of graft loss and dysfunction in clinical transplantation and organ resection. [...]. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms19124093
更新日期:2018-12-18 00:00:00
abstract::The neuroinflammatory response to peripheral nerve injury is associated with chronic pain and significant changes in the molecular expression profiles of mRNAs in neurons, glia and infiltrating immune cells. Chronic constriction injury (CCI) of the rat sciatic nerve provides an opportunity to mimic neuropathic injury ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215269
更新日期:2019-10-24 00:00:00
abstract::In this study, drug nanocarriers were designed using linear copolymers with different contents of cholinium-based ionic liquid units, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMAMA/Cl: 25, 50, and 75 mol%). The amphiphilicity of the copolymers was evaluated on the basis of their critical micelle con...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010284
更新日期:2020-12-30 00:00:00
abstract::The translation of metallothioneins (MTs) is one of the defense strategies by which organisms protect themselves from metal-induced toxicity. MTs belong to a family of proteins comprising MT-1, MT-2, MT-3, and MT-4 classes, with multiple isoforms within each class. The main aim of this study was to determine the behav...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18030610
更新日期:2017-03-11 00:00:00
abstract::The present study was designed to probe the effects of Huperzine A (HupA) on diabetes-associated cognitive decline (DACD) using a streptozotocin (STZ)-injected rat model. Diabetic rats were treated with HupA (0.05 and 0.1 mg/kg) for seven weeks. Memory functions were evaluated by the water maze test. Nissl staining wa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15057667
更新日期:2014-05-05 00:00:00
abstract::Nanoscience and nanotechnology shows immense interest in various areas of research and applications, including biotechnology, biomedical sciences, nanomedicine, and veterinary medicine. Studies and application of nanotechnology was explored very extensively in the human medical field and also studies undertaken in rod...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19113299
更新日期:2018-10-24 00:00:00
abstract::The last step in the biosynthesis of flavin adenine dinucleotide (FAD) is considered a target for the design of antimicrobial drugs because it is carried out by two non-homologous proteins in eukaryotic and prokaryotic organisms. Monofunctional FMN: adenylyltransferases (FMNAT) in Eukarya and FMNAT modules of bifuncti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21103738
更新日期:2020-05-25 00:00:00