Abstract:
:The molecular circadian clocks in the mammalian retina are locally synchronized by environmental light cycles independent of the suprachiasmatic nuclei (SCN) in the brain. Unexpectedly, this entrainment does not require rods, cones, or melanopsin (OPN4), possibly suggesting the involvement of another retinal photopigment. Here, we show that the ex vivo mouse retinal rhythm is most sensitive to short-wavelength light but that this photoentrainment requires neither the short-wavelength-sensitive cone pigment [S-pigment or cone opsin (OPN1SW)] nor encephalopsin (OPN3). However, retinas lacking neuropsin (OPN5) fail to photoentrain, even though other visual functions appear largely normal. Initial evidence suggests that OPN5 is expressed in select retinal ganglion cells. Remarkably, the mouse corneal circadian rhythm is also photoentrainable ex vivo, and this photoentrainment likewise requires OPN5. Our findings reveal a light-sensing function for mammalian OPN5, until now an orphan opsin.
journal_name
Proc Natl Acad Sci U S Aauthors
Buhr ED,Yue WW,Ren X,Jiang Z,Liao HW,Mei X,Vemaraju S,Nguyen MT,Reed RR,Lang RA,Yau KW,Van Gelder RNdoi
10.1073/pnas.1516259112subject
Has Abstractpub_date
2015-10-20 00:00:00pages
13093-8issue
42eissn
0027-8424issn
1091-6490pii
1516259112journal_volume
112pub_type
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