Abstract：
PURPOSE:To compare characteristics of functioning blebs (FBs) and nonfunctioning blebs (NFBs) with en-face spectral-domain optical coherence tomography (OCT). METHODS:We evaluated 41 blebs of 38 patients after a first-time trabeculectomy. Eyes were classified into 2 groups: FBs (22 eyes) and NFBs (19 eyes). En-face OCT images were analyzed semiquantitatively for the density of intraepithelial microcysts (0 to 3), internal fluid-filled cavity (0 to 3), and bleb vascularization (0 to 2). Presence of conjunctival fibrosis and visualization of the scleral flap were also analyzed. RESULTS:FBs showed significantly more intraepithelial microcysts than did NFBs: the mean grading of microcyst density was 1.86 for FBs and 0.11 for NFBs (P<0.0001). None of the FBs were rated 0 and none of the NFBs were rated 2 or 3 for the density of intraepithelial microcysts. NFBs presented more conjunctival fibrosis than FBs (63% vs. 32%, P<0.05). There was no significant difference between FBs and NFBs for bleb vascularization, visualization of the scleral flap, and presence of subepithelial fluid-filled cavities. There was a direct correlation between postoperative intraocular pressure and intraepithelial microcyst density (r=-0.7655, P<0.0001). The long-term administration of preserved eyedrops before surgery was associated with fewer intraepithelial microcysts (r=-0.5436; P=0.0006). CONCLUSIONS:FBs were associated with a higher number of intraepithelial microcysts evaluated with en-face OCT. A higher density of microcysts was associated with a lower intraocular pressure and a shorter duration of preserved topical treatment before surgery. En-face OCT provides a simple, noninvasive, and reproducible method to analyze blebs after filtering surgery.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Meziani L,Tahiri Joutei Hassani R,El Sanharawi M,Brasnu E,Liang H,Hamard P,Baudouin C,Labbe Adoi
10.1097/IJG.0000000000000319subject
Has Abstractpub_date
2016-05-01 00:00:00pages
e550-8issue
5eissn
1057-0829issn
1536-481Xjournal_volume
25pub_type
杂志文章abstract：OBJECTIVES:This study was conducted to evaluate the effect of long-term intraocular pressure reduction with timolol on the incidence of glaucomatous visual field defects and optic nerve cupping in individuals with ocular hypertension and to compare this incidence with that of a similar group on no treatment. ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:The purpose of this study is to describe the outcomes of mitomycin C (MMC)-augmented trabeculectomy performed following a failed MMC-augmented XEN-45 implantation. DESIGN:Retrospective case series. METHODS:All consecutive cases of MMC-augmented trabeculectomy performed after MMC-augmented XEN-45 in the Glauco...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001000
更新日期：2018-10-01 00:00:00
abstract：INTRODUCTION:Glaucoma in patients with nonbullous congenital ichthyosiform erythroderma (NBCIE) is a rare entity that has not been described in a histologically confirmed case. We present a unique case of coexisting glaucoma, ichthyosis, and dwarfism that has not been previously described. METHODS:We present a case of...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001016
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:Pachymetry plays a crucial role in the diagnosis and management of glaucoma and corneal diseases. There have been several outbreaks of epidemic ocular infections in ophthalmology clinics worldwide with reports of viral, parasitic, and prion disease. Contact pachymetry is a possible vehicle of transmission due...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001525
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:To describe the outcome of surgical bleb revision for late-onset bleb leaks after trabeculectomy. PATIENTS AND METHODS:Appropriate cases were identified. Qualified and complete success required intraocular pressure of 21 mm Hg or less with and without glaucoma medication use, respectively. Bleb survival was de...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31821e83e6
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Glaucoma drainage implantation in conjunction with Boston Type 1 Keratoprosthesis placement is a surgical option in controlling postoperative glaucoma. The purpose of this study is to report outcomes of combined pars plana vitrectomy and glaucoma drainage implantation with corneal patch graft in Boston Type 1 K...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31829e55f8
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:The Molteno implant is one of the most widely used drainage devices for the management of complicated glaucoma. Antiproliferative agents such as mitomycin-C (MMC) have markedly improved the outcome of glaucoma filtering surgery. This case control study compares the results of these two techniques in the managem...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：PURPOSE:To elucidate the relationship between macular retinal thickness and corresponding superior or inferior visual hemifield defects in glaucoma patients. METHODS:Thirty-nine eyes of 39 patients with open-angle glaucoma showed superior or inferior hemifield defects (superior hemifield defects, 27 eyes; inferior hem...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e318225472a
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:To evaluate the outcomes of selective laser trabeculoplasty (SLT) in patients with primary angle closure (PAC/PACG) following a YAG peripheral laser iridotomy (PI) compared with primary open-angle glaucoma (POAG). METHODS:A case-control study compared the effectiveness of SLT in PAC/PACG to POAG. Data from pat...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000282
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP). METHODS:Four hundred twenty-two eyes (78 healthy, 210 suspects, 134 glaucomatous) of 250 patients were recruited from the...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31822af27a
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:This meta-analysis aims to comprehensively evaluate the association between total homocysteine (tHcy) levels, serum folic acid, vitamin B12, vitamin B6 levels, methylenetetrahydrofolate reductase (MTHFR) C677T genotype, and risk of normal-tension glaucoma (NTG). MATERIALS AND METHODS:A systematic search of ...
journal_title：Journal of glaucoma
pub_type： 杂志文章,meta分析
doi：10.1097/IJG.0000000000000269
更新日期：2016-02-01 00:00:00
abstract：AIMS:An observational study to determine the safety and efficacy of filtering surgery employing a microlumen aqueous drainage device (InnFocus MicroShunt), used intraoperatively with Mitomycin C, implanted alone or in combination with phacoemulsification. MATERIALS AND METHODS:Single-site, prospective, nonrandomized s...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000368
更新日期：2016-02-01 00:00:00
abstract：:A 51-year-old white man presented with multiple episodes of transient painless unilateral vision loss precipitated by sexual intercourse. Examination was significant for closed angles bilaterally. His visual symptoms completely resolved following treatment with laser peripheral iridotomies. ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000165
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:To evaluate whether postural changes of intraocular pressure (IOP) are associated with visual field damage by comparing both eyes of patients with previously untreated normal-tension glaucoma (NTG). PATIENTS AND METHODS:Forty eyes of 20 patients newly diagnosed as bilateral NTG were studied. IOP was measured i...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3181a98f30
更新日期：2010-03-01 00:00:00
abstract：PURPOSE:To investigate the meibomian gland (MG) performance in patients with glaucoma under topical intraocular pressure (IOP)-lowering medications. MATERIALS AND METHODS:This was a cross-sectional case-control study. Patients with glaucoma under different dosages and instillation periods of topical IOP-lowering medic...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000841
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:The author studied the effects of pupillary dilation on perimetry in a group of glaucomatous patients receiving timolol therapy. PATIENTS AND METHODS:A prospective study compared the visual fields of 23 patients with primary open-angle glaucoma of varying severity (mean defect: 3.84; short-term fluctuation: 1....
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：PURPOSE:The purpose of the study was to compare radial peripapillary capillary (RPC) density between normal subjects and patients with early primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCT-A). MATERIALS AND METHODS:A total of 24 patients with early POAG and age-matched 52 normal ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000649
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:To evaluate the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex, and macular thickness as well as their correlation with the severity of diseases. MATERIALS AND METHODS:This is a cross-sectional study and comparing both eyes of 26 patients with primary open-angle glaucoma, 25 patients wit...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000239
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:To determine prevalence and associated factors of ocular hypertension in the adult Chinese population. METHODS:The Beijing Eye Study, a population-based prevalence study, included 4439 subjects out of 5324 subjects with an age of 40+ years invited to participate (response rate 83.4%). From the 4439 individuals...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31816b301e
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:Subconjunctival mitomycin C has been used in glaucoma filtration surgery with success. A prospective, randomized, masked, placebo-controlled study was performed to evaluate whether single transconjunctival mitomycin C applied either preoperatively or postoperatively would enhance the success of filtration surge...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：PURPOSE:To evaluate tonometric outcomes of patients with primary angle closure glaucoma (PACG) who have undergone trabeculectomy with mitomycin C (MMC) with and without concurrent phacoemulsification and to identify risk factors for postoperative failure. PATIENTS AND METHODS:Retrospective cohort study of 44 eyes of 3...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000493
更新日期：2016-09-01 00:00:00
abstract：:Primary intraocular lymphoma can cause an elevation of intraocular pressure (IOP), resulting from infiltration of the trabecular meshwork with neoplastic lymphocytes. More rarely, therapeutic procedures can induce a highly synchronised death of tumor cells, leading to congestion of the trabecular meshwork with cell de...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31827a0875
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:To characterize and compare the ocular comfort and symptoms of dorzolamide and tear-replacement drops (placebo) in healthy volunteers. PATIENTS AND METHODS:Subjects were randomized in a double-masked fashion to receive each medicine for 6 days twice daily. Patients used a visual analog scale to assess the qual...
journal_title：Journal of glaucoma
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00061198-200304000-00010
更新日期：2003-04-01 00:00:00
abstract：STUDY OBJECTIVES:The association between obstructive sleep apnea syndrome (OSAS) and retinal nerve fiber layer (RNFL) thickness has been examined in many studies. However, the findings are inconsistent. Our goal is to evaluate the association between OSAS and RNFL thickness by performing a meta-analysis. METHODS:We co...
journal_title：Journal of glaucoma
pub_type： 杂志文章,meta分析
doi：10.1097/IJG.0000000000000349
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:To assess the efficacy of collagen cross-linking in the treatment of late-onset bleb leakage. METHODS:A retrospective, interventional case-series. Cross-linking was performed for late-onset bleb leakage after failure of standard medical therapy. Primary outcome is measured by complete resolution of bleb leakag...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000295
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To assess and compare the impact of medical and surgical glaucoma treatments on patients' health-related Quality of Life (QoL). MATERIALS AND METHODS:We used the 25-question version of the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) for this cross-sectional study. Patients were divided...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31824ceb8b
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:The aim of this study is to evaluate the safety and efficacy of laser goniopuncture (LGP) to lower intraocular pressure (IOP) post-viscocanalostomy (VC)/phacoviscocanalostomy (PVC). Outcomes include: IOP reduction from pre-LGP levels and the need for further topical antiglaucomatous medication or surgery. PATI...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000333
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:To assess the ability of frequency-doubling technology (FDT) perimetry and short-wavelength automated perimetry (SWAP) to detect glaucomatous damage in preperimetric glaucoma subjects. PARTICIPANTS:Two hundred seventy-eight eyes of 278 subjects categorized as normal eyes [n=98; intraocular pressure <20 mm Hg, ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31803bbb17
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:To investigate the relationship between retinal nerve fiber layer (RNFL) measurements in corresponding areas obtained with scanning laser polarimetry and optical coherence tomography and to compare their discriminating ability in the diagnosis of preperimetric and perimetric glaucoma. PATIENTS AND METHODS:Thre...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3181a2fc0e
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:Upper eyelid sulcus deepening has recently been reported as an adverse effect of prostaglandin (PG) eye drop use. However, no data are available regarding the frequency of upper eyelid sulcus deepening caused by different types of PG eye drops. We used 5 types of PG eye drops in Japanese subjects and examined t...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31824d8d7c
更新日期：2013-10-01 00:00:00
