Effects of Referral Bias on Estimates of Anal Intraepithelial Neoplasia Progression and Regression Rates in a 3-State Markov Model.

Abstract:

:The study aim is to compare anal intraepithelial neoplasia (AIN) progression and regression rates in a cytology inception cohort to estimates based on the subcohort referred for ≥1 high-resolution anoscopies (HRAs).A cytology-based retrospective cohort was assembled including the anal cytology histories and invasive anal cancer (IAC) outcomes of all HIV-infected adults under care between 2001 and 2012. A 3-state Markov model (400, and to have HSIL at baseline and thereafter. They also had more anal cytology examinations (median 6 vs 3) and longer follow-up (median 5.5 vs 3.6 years). State transition rates were overestimated in the HRA subcohort relative to inception cohort, but the degree of discordance varied by transition: for

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Mathews WC,Cachay ER,Agmas W,Jackson C

doi

10.1097/MD.0000000000001476

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

e1476

issue

35

eissn

0025-7974

issn

1536-5964

pii

00005792-201509010-00030

journal_volume

94

pub_type

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