Abstract:
INTRODUCTION:Type 2 diabetes mellitus (T2DM) is a metabolic disease with widespread concern in the world. It has the characteristics of high incidence rate and high disability rate, which seriously affects economic and social development. large dose herb Rhizoma Coptidis (Huanglian) and Scutellaria (Huangqin) or compound prescription contain large dose Huanglian and Huanglian for treatment of T2DM has already been confirmed. However, due to the lack of evidence, there is no specific method or suggestion, so it is necessary to carry out systematic evaluation on Coptidis and Scutellaria and provide effective evidence for further research. METHODS AND ANALYSIS:The following databases will be searched from their inception to June 2020: Electronic database includes PubMed, Embase, Cochrane Library, Web of Science, Nature, Science online, Chinese Biomedical Database WanFang, VIP medicine information, and China National Knowledge Infrastructure. Primary outcomes: fasting blood-glucose (FBG), 2 Hours Postprandial Blood Glucose (2hPBG), Glycosylated hemoglobin A1c (HbA1c). additional outcomes: Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), triglycerides (TG), total serum cholesterol (TC). Data will be extracted by 2 researchers independently, risk of bias of the meta-analysis will be evaluated based on the Cochrane Handbook for Systematic Reviews of Interventions. All data analysis will be conducted by data statistics software Review Manager V.5.3. and Stata V.12.0. RESULTS:The results of this study will systematically evaluate the effectiveness and safety of large dose Huanglian and Huangqin intervention for people with T2DM. CONCLUSION:The systematic review of this study will summarize the current published evidence of large dose Huanglian and Huangqin for the treatment of T2DM, which can further guide the promotion and application of it. ETHICS AND DISSEMINATION:This study is a systematic review, the outcomes are based on the published evidence, so examination and agreement by the ethics committee are not required in this study. We intend to publish the study results in a journal or conference presentations. OPEN SCIENCE FRAMEWORK (OSF) REGISTRATION NUMBER:July 21, 2020. osf.io/b6r3z. (https://osf.io/b6r3z).
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Huang X,Wang L,Yue R,Ding N,Yang Hdoi
10.1097/MD.0000000000022032subject
Has Abstractpub_date
2020-09-18 00:00:00pages
e22032issue
38eissn
0025-7974issn
1536-5964pii
00005792-202009180-00017journal_volume
99pub_type
杂志文章,meta分析相关文献
MEDICINE文献大全abstract::This study aimed to assess the efficacy and safety of bevacizumab plus preoperative chemotherapy as first-line treatment for liver-only metastatic colorectal cancer in Chinese patients compared with those of preoperative chemotherapy alone.Patients with histologically confirmed liver-only metastatic colorectal cancer ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004767
更新日期:2016-08-01 00:00:00
abstract::The inferior border of the femoral head (IBFH) is widely used as a landmark in femoral artery puncture during invasive coronary angiography (ICA). However, application of this technique can be challenging especially in obese patients. This study was performed to investigate the association between body mass index (BMI...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010070
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Parkinson disease (PD) is a progressive neuromuscular disease associated with bradykinesia, tremor, and postural instability. We aimed to compare outcomes and complications of total hip arthroplasty (THA) between patients with PD and those without. METHODS:A single institution retrospective cohort from 2000...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020018
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION:Duodenal obstructions caused by congenital anatomic abnormalities are rare in adults. Several patients in whom the duodenal obstruction was caused by a congenital duodenal diaphragm have been described. The duodenal obstruction in the patient presented herein was caused by a transverse septum, which has no...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007093
更新日期:2017-10-01 00:00:00
abstract:RATIONALE:Late complement deficiency increases susceptibility to meningococcal disease and recurrent infections. In Korea, 5 case reports have described meningococcal disease with complement deficiency. However, C6 deficiency has not been described previously. PATIENT CONCERNS:A 21-year-old police trainee presented wi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020362
更新日期:2020-05-22 00:00:00
abstract:BACKGROUND:National Comprehensive Cancer Network (NCCN) guidelines recommend surgery, chemotherapy, and radiation therapy for gastric cancer patients. Neoadjuvant treatments as the administration of therapeutic agents before a main treatment gained in more and more attention. However, the role of neoadjuvant treatments...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000010392
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Pentraxin 3 is an acute inflammatory protein of the long pentraxin subfamily. A meta-analysis was performed to assess diagnostic accuracy of pentraxin 3 for respiratory tract infections. METHODS:We identify studies examining diagnostic value of pentraxin 3 for respiratory tract infections by searching Pubme...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019532
更新日期:2020-04-01 00:00:00
abstract::Gynecologic vasculitis (GynV) has been reported as part of systemic vasculitis (SGynV) and as single-organ (isolated gynecologic) vasculitis (IGynV). In the current study, we analyzed the clinical and histologic characteristics of patients with GynV and sought to identify features that differentiate the isolated from ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e3181a577f3
更新日期:2009-05-01 00:00:00
abstract:INDUCTION:Liver transplantation (LT) is the only final therapy for patients with acute liver failure (ALF) that cannot be controlled by conservative treatment. Acute pancreatitis (AP) is a recognized complication of ALF. The pathogenesis of AP in ALF patients has not yet been elucidated. The appearance of AP complicate...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022934
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:The study is inclined to investigate the antagonistic effects of endostatin-vascular endothelial growth inhibitor chimeric recombinant adenovirus (Ad-hENDO-VEGI) on homocysteine (Hcy)-induced vascular endothelial cells (VECs) injury in vitro and in vivo. METHODS:Human VECs cell line ECV304 was selected and ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005197
更新日期:2016-11-01 00:00:00
abstract::Like research in general internal medicine, family medicine research can play an important role in improving medical knowledge. We aimed to compare articles published in family medicine journals with articles published in general internal medicine journals. In this bibliometric study, we retrieved 658 randomly selecte...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020586
更新日期:2020-06-12 00:00:00
abstract::Folate receptor-mediated staining solution detection (FRD) has been recently suggested as an effective tool in the cervical cancer screening. We aim to compare the accuracy of FRD to human papillomavirus (HPV) and thinprep cytology test (TCT) based on cytology-based biopsy.During May 2016 and December 2016, we recruit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011868
更新日期:2018-08-01 00:00:00
abstract:RATIONALE:Prepubertal unilateral gynecomastia is extremely rare, whose etiology and management strategy are not familiar. We would like to present a case and a literature review of unilateral prepubertal gynecomastia. PATIENT CONCERNS:A 11-year old male patient with complaints of unilateral enlargement of breast tissu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017374
更新日期:2019-10-01 00:00:00
abstract:INTRODUCTION:Duplication of the gallbladder (GB) is a rare congenital abnormality occurring in 1 in 4000 to 5000 births. Three types have been reported: type I (split primordial GB), type II (2 separate GBs with their own cystic ducts), and type III (triple GBs drained by 1 to 3 separate cystic ducts). Patients with a ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018363
更新日期:2020-01-01 00:00:00
abstract:RATIONALE:Vortioxetine is a new multimodal antidepressant approved by the Food and Drug Administration for the treatment of Major Depressive Disorder and recently introduced in Europe. While antidepressant properties of vortioxetine and its tolerability have been demonstrated by preclinical and clinical studies data on...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010788
更新日期:2018-06-01 00:00:00
abstract::Ischemic strokes presenting with isolated acute vestibular syndrome (AVS) are not rare and still are challenging for diagnosis. In this retrospective study, we aimed to investigate the association of high-sensitivity C-reactive protein (hs-CRP) with stroke in patients with isolated AVS. A total of 217 patients with is...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018097
更新日期:2019-11-01 00:00:00
abstract::Children who underwent surgery for complex congenital heart defects present worse exercise capacity than their healthy peers. In adults and adolescents, heart failure is assessed on the basis of clinical symptoms using the New York Heart Association (NYHA) score, while in an infant Ross scale; heart failure can also b...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002619
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Infantile fever is a common symptom of the pediatric diseases, which is often caused by cold, food accumulation, or other pathogenic factors. Pediatric tuina is regarded as an acceptable non-pharmaceutical therapy for children with optimal effects, which has been widely used for infantile fever around China....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021664
更新日期:2020-08-14 00:00:00
abstract:UNLABELLED:Cisplatin (CDDP) plus radiotherapy (RT) has been used to treat advanced laryngeal squamous cell carcinoma (LSCC) patients. Single nucleotide polymorphisms (SNPs) may be responsible for differences in chemo/radiosensitivity and side effects in those patients. We reported an advanced LSCC patient, who obtained...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000578
更新日期:2015-04-01 00:00:00
abstract::Hamartomas are very rarely identified as an endobronchial lesion. Herein, we describe a peculiar case of a 55-year-old woman with persistent cough and increasing dyspnea and radiological detection of a solid lesion subtotally occluding the main right bronchus. Despite the radiological and radiometabolic (18-fluoro-2-d...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003369
更新日期:2016-04-01 00:00:00
abstract:RATIONALE:Pulmonary hyalinizing granuloma (PHG) is a rare benign disease that has been shown to be associated with the deposition of immune complexes in the lung parenchyma caused by infection or autoimmune diseases. There have been no reports of PHG in association with immunoglobulin A nephropathy (IgAN). PATIENT CON...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009088
更新日期:2017-12-01 00:00:00
abstract::The aim of the study is to assess the prognostic value of different volume-based calculations of tumor metabolic activity in the initial assessment of patients with high-grade bone sarcomas (BS) and soft tissue sarcomas (STS) using F-18 FDG PET/CT.A single-site, retrospective study from 2002 to 2012 including 92 patie...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002319
更新日期:2015-12-01 00:00:00
abstract::The present study investigated the effectiveness of a Carisolv III + 0.5% sodium hypochlorite (NaOCl)-based root canal irrigant for smear layer removal.Forty maxillary incisors were randomly divided into 4 groups (n = 10 per group). The canals in group A (experimental) were prepared with 0.5% NaOCl, and Carisolv III a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020372
更新日期:2020-05-29 00:00:00
abstract::The aim of the present study is to investigate the value of air bronchogram sign on computed tomography (CT) image in the differential diagnosis of solitary pulmonary consolidation lesions (SPLs).A total of 105 patients (including 39 cases of lung cancer, 43 cases of tuberculosis, and 23 cases of pneumonia) with SPLs ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011985
更新日期:2018-08-01 00:00:00
abstract::We studied 121 patients with systemic lupus erythematosus (SLE), of whom 119 were complement typed. Both black and white patients with SLE were more likely than racially matched controls to have a C4A null allotype. Patients with homozygous C4A deficiency had less proteinuria than other patients (p = 0.02) and both ho...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199307000-00003
更新日期:1993-07-01 00:00:00
abstract::Two patients with plasma cell dyscrasias, manifested by osteosclerotic bone lesions and small amounts of M protein, and a complicating multi-system disorder are described. Their features of severe sensory-motor polyneuropathy, organomegaly, endocrine dysfunction, anasarca, elevated CSF protein, and skin hyperpigmentat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-198007000-00006
更新日期:1980-07-01 00:00:00
abstract::Aortoiliac occlusive disease (AIOD) affects the systemic vascular resistance and increases the afterload because the left ventricle (LV) must work harder to eject blood into a smaller vascular bed. This study was to determine whether successful revascularization of AIOD is associated with improvement of left ventricul...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012339
更新日期:2018-09-01 00:00:00
abstract:INTRODUCTION:Cerebrovascular imaging is the gold standard for diagnosis of intracranial aneurysms. Rupture of intracranial aneurysm is rare in cerebrovascular angiography, especially in unruptured intracranial aneurysm. PATIENT CONCERNS:A 74-year-old woman was admitted to the hospital for sudden onset of left eyelid p...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017785
更新日期:2019-11-01 00:00:00
abstract::Alpha-fetoprotein (AFP) has not played a large role in the surveillance of hepatocellular carcinoma due to inadequate sensitivity and specificity for active chronic hepatitis or cirrhosis. The aim of this study was to evaluate the diagnostic accuracy of AFP in small hepatocellular carcinomas after hepatitis C virus er...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000901
更新日期:2015-06-01 00:00:00
abstract::Familial amyloid polyneuropathy (FAP) is an autosomal dominant disease associated with the mutations in the transthyretin gene. To date, the endoscopic findings of the small-bowel lesions of FAP have never been described. We report a rare case of FAP with gastrointestinal involvement. A 71-year-old woman complaining o...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002896
更新日期:2016-03-01 00:00:00