Abstract:
RATIONALE:Studies performed in animal models of corneal neovascularization suggested the possible efficacy of a treatment with propranolol. Corneal neovascularization is one of the most feared complications of Stevens-Johnson syndrome that frequently involves ocular surface. We report the first 2 patients with severe ocular neo-vascularization treated with different degrees of success, with propranolol eye drops. PATIENT CONCERNS:Two patients with corneal neovascularization complicating the Stevens-Johnson syndrome, not responsive to steroids and cyclosporine, were treated with propranolol eye drops. DIAGNOSES:Corneal neovascularization was detected by ophthalmoscopic evaluation. INTERVENTIONS:Topical treatment with propranolol eye drops at different concentrations. OUTCOMES:Both patients reported dramatic subjective benefits (reduction of photophobia and discomfort) without adverse effects, and in the patient with a less advanced disease, an objective reduction of neovascularization and an improved visual acuity was observed. LESSONS:This experience suggests that propranolol might be an inexpensive, safe and effective treatment in counteracting the progression of corneal neovascularization.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Filippi L,de Libero C,Zamma Gallarati B,Fortunato P,Piozzi Edoi
10.1097/MD.0000000000013002subject
Has Abstractpub_date
2018-11-01 00:00:00pages
e13002issue
45eissn
0025-7974issn
1536-5964pii
00005792-201811090-00013journal_volume
97pub_type
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