Abstract:
BACKGROUND:The blood-brain barrier is impaired in patients with stroke. The release of protein markers such as Sirtuin1 (SIRTl) into circulation may be useful to assess the prognosis of patients with cerebrovascular disease. In this study, we investigated the predictive value of SIRT1 levels in acute ischemic stroke (AIS) patients. METHODS:In all, 101 AIS patients and 38 healthy controls were enrolled, and blood samples were collected within 72 hours of stroke onset. SIRT1 was analyzed using a commercially available enzyme-linked immunosorbent assay kit. On admission, neurological status was assessed by the standardized National Institutes of Health Stroke Scale (NIHSS). Functional outcomes were measured 1 year after admission using the modified Rankin scale. RESULTS:Compared with the control group, SIRT1 was significantly increased in the AIS group (0.63 ± 0.75 vs 0.48 ± 0.80 ng/mL; P ≤ 0.05). However, there was no significant correlation between SIRT1 and NIHSS score at admission (r = -0.01, P = .920). In addition, with an unadjusted odds ratio of 0.862 (95% confidence interval 0.495-1.502), SIRT1 was not significantly correlated with functional outcomes. CONCLUSIONS:Serum concentrations of SIRT1 have no significant predictive value for favorable functional outcome after acute stroke in our study.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Liu Y,Jia S,Liang X,Dong M,Xu X,Lu C,Wei Ydoi
10.1097/MD.0000000000012959subject
Has Abstractpub_date
2018-12-01 00:00:00pages
e12959issue
49eissn
0025-7974issn
1536-5964pii
00005792-201812070-00005journal_volume
97pub_type
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