Abstract:
:Ankylosing spondylitis (AS) is a common and genetically heterozygous inflammatory rheumatic disease characterized by new bone formation, ankylosis and inflammation of hip, sacroiliac joints and spine. Until now, there is no method for early diagnosis of AS and the effective treatment available for AS patients remain largely undefined.We searched articles indexed in PubMed (MEDLINE) database using Medical Subject Heading (MeSH) or Title/Abstract words ("microRNA" and "ankylosing spondylitis") from inception up to November 2015.Genetic polymorphisms of miRNAs and their targets might alter the risk of AS development whereas certain miRNAs exhibit correlation with inflammatory index.Let-7i and miR-124 were upregulated whereas miR-130a was downregulated in circulating immune cells of AS patients. These deregulated miRNAs could modulate key immune cell functions, such as cytokine response and T-cell survival.miRNA deregulation is key to AS pathogenesis. However, clinical utilization of miRNAs for management of AS patients requires further support from future translational studies.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Li Z,Wong SH,Shen J,Chan MTV,Wu WKKdoi
10.1097/MD.0000000000003325subject
Has Abstractpub_date
2016-04-01 00:00:00pages
e3325issue
14eissn
0025-7974issn
1536-5964pii
00005792-201604050-00086journal_volume
95pub_type
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