Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B.


OBJECTIVE:To explore the effect of ginkgo biloba extract (EGb) as an adjunctive treatment of elderly patients with depression and the effect on the expression of serum S100B. METHODS:136 elderly patients with depression were divided into EGb +  citalopram (Cit) group and Cit group equally. Efficacy was evaluated by Hamilton Depression Rating Scale (HAMD). Wisconsin Card Classification Test (WCST) was used to evaluate cognitive function. Serum S100B expression was measured with ELISA. The relationship of S100B with HAMD, Hamilton Anxiety Scale (HAMA) score, and WCST results was evaluated subsequently. RESULTS:The time of onset of efficacy was significantly shorter in EGb + Cit group. There were significant differences in HAMD and HAMA scores after treatment than before treatment between groups (all P < .05). After treatment, total number of WCST test, the number of continuous errors and non-persistent errors in both groups were less than those before treatment. The correct number and classifications number were increased than before treatment. In EGb + Cit group, correct numbers and classifications were increased, and the number of persistent errors was decreased. After treatment, S100B level was decreased, and S100B levels change in EGb + Cit group was greater than in Cit group. Serum S100B level was positively correlated with HAMD and HAMA scores before treatment and positively correlated with persistent errors number in WCST. CONCLUSION:EGb, as an adjunctive treatment, can effectively improve depressive symptoms and reduce expression of serum S100B, which is a marker of brain injury, suggesting that EGb restores neurologic function during the treatment of depression in elderly patients and S100B participates in the therapeutic mechanism. EGb combined with depressive drugs plays synergistic role, and the time of onset of efficacy is faster than single antidepressants.


Medicine (Baltimore)




Dai CX,Hu CC,Shang YS,Xie J




Has Abstract


2018-09-01 00:00:00
















  • Genetic Association Between NFKBIA -881A>G Polymorphism and Cancer Susceptibility.

    abstract::Several epidemiological studies have focused on the role of nuclear factor-kappa-B inhibitor-alpha (NFKBIA) -881 A>G polymorphism in cancer susceptibility. However, the published data have led to contentious results. This study was designed to examine the association between -881 A>G polymorphism and cancer risk.Compr...


    pub_type: 杂志文章,meta分析,评审


    authors: Geng P,Ou J,Li J,Liao Y,Wang N,Sa R,Xiang L,Liang H

    更新日期:2015-08-01 00:00:00

  • Identification of osteoporosis markers through bioinformatic functional analysis of serum proteome.

    abstract::Osteoporosis is a severe chronic skeletal disorder that increases the risks of disability and mortality; however, the mechanism of this disease and the protein markers for prognosis of osteoporosis have not been well characterized. This study aims to characterize the imbalanced serum proteostasis, the disturbed pathwa...


    pub_type: 杂志文章


    authors: Lv M,Cui C,Chen P,Li Z

    更新日期:2020-09-25 00:00:00

  • Timescale of tumor volume of a young breast cancer patient with luminal B subtype: A case report.

    abstract:RATIONALE:It is largely unknown about the tumor growth of breast cancer naturally. We devised and analyzed an appropriate mathematical tool of the equations that describe how fast tumors grow without treatment on the basis of the ellipsoid shape of solid breast cancer. PATIENT CONCERNS:A 31-year-old woman presented wi...


    pub_type: 杂志文章


    authors: Mao X,Zhou M,Fan C,Chen B,Jin F

    更新日期:2019-10-01 00:00:00

  • Sero-survey of polio antibodies and quality of acute flaccid paralysis surveillance in Chongqing, China: A cross-sectional study.

    abstract::Serums were collected from people to assess whether polio immunity level was high enough to satisfy the polio vaccine immunization switch in Chongqing.People in 7 age groups (<1 year, 1-2 years, 3-4 years, 5-6 years, 7-14 years, 15-19 years, ≧20 years) were randomly selected in 3 areas by different geographical featur...


    pub_type: 杂志文章


    authors: Xu J,Kuang S,Rong R,Zhang Y,Tang W,Wang Q

    更新日期:2020-07-31 00:00:00

  • Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer.

    abstract::Nuclear factor-κB-inducing kinase (NIK) is a new regulator of nuclear factor-κB signaling, which plays an important role in tumorigenesis. This study aimed to examine the expression of NIK in gastric cancer and investigate its clinical significance.Tumor issues were collected from 80 gastric cancer patients who receiv...


    pub_type: 杂志文章


    authors: Teng H,Xue L,Wang Y,Ding X,Li J

    更新日期:2020-01-01 00:00:00

  • Effects of early parenteral iron combined erythropoietin in preterm infants: A randomized controlled trial.

    abstract:BACKGROUD:The aim of the study was to evaluate the effect of early parenteral iron supplementation combined erythropoietin for prevention of anemia in preterm infants. METHODS:In total, 96 preterm infants were randomly assigned to 3 groups: a control group receiving standard parenteral nutrition (group 1: n = 31), an ...


    pub_type: 杂志文章,随机对照试验


    authors: Qiao L,Tang Q,Zhu W,Zhang H,Zhu Y,Wang H

    更新日期:2017-03-01 00:00:00

  • Assessment of ankle and hindfoot stability and joint pressures using a human cadaveric model of a large lateral talar process excision: a biomechanical study.

    abstract::Lateral talar process fragment excision may be followed by hindfoot instability and altered biomechanics. There is controversy regarding the ideal fragment size for internal fixation versus excision and a concern that excision of a large fragment may lead to significant instability. The aim of this study was to assess...


    pub_type: 杂志文章


    authors: Sands A,White C,Blankstein M,Zderic I,Wahl D,Ernst M,Windolf M,Hagen JE,Richards RG,Stoffel K,Gueorguiev B

    更新日期:2015-03-01 00:00:00

  • Age- and sex-related differences in body composition in healthy subjects aged 18 to 82 years.

    abstract::Significant changes in body composition are known to occur with aging. The aim of the present study was to provide a normative reference of body composition and to investigate age and sex-related differences in healthy subjects by multifrequency bioelectrical impedance analyzer (BIA).A cross-sectional study was conduc...


    pub_type: 杂志文章


    authors: He X,Li Z,Tang X,Zhang L,Wang L,He Y,Jin T,Yuan D

    更新日期:2018-06-01 00:00:00

  • Enterohepatic Helicobacter Species as a Potential Causative Factor in Inflammatory Bowel Disease: A Meta-Analysis.

    abstract::The Helicobacter species in the gut microbiota comprise Helicobacter pylori (H pylori) and enterohepatic Helicobacter species (EHS), which can colonize the intestinal mucosa. However, it is unclear whether EHS are associated with inflammatory bowel disease (IBD). Therefore, we conducted this meta-analysis to examine t...


    pub_type: 杂志文章,meta分析,评审


    authors: Yu Q,Zhang S,Li L,Xiong L,Chao K,Zhong B,Li Y,Wang H,Chen M

    更新日期:2015-11-01 00:00:00

  • Nurses' objective knowledge regarding venous thromboembolism prophylaxis: A national survey study.

    abstract::Venous thromboembolism (VTE) is a common vascular disorder with high mortality and morbidity. Clinical nurses are a pivotal group that can serve as first-line health care providers. Lack of knowledge about VTE is an important barrier to effective nursing performance. This study aimed to determine nurses' knowledge of ...


    pub_type: 杂志文章


    authors: Ma YF,Xu Y,Chen YP,Wang XJ,Deng HB,He Y,Wu XJ

    更新日期:2018-04-01 00:00:00

  • Role of immune cells in pancreatic cancer from bench to clinical application: An updated review.

    abstract:BACKGROUND:Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies. Immuno-inflammatory response is considered to be a major risk factor for the development of PC in addition to a combination of genetic background and environmental factors. Although patients with P...


    pub_type: 杂志文章,评审


    authors: Chang JH,Jiang Y,Pillarisetty VG

    更新日期:2016-12-01 00:00:00

  • Effectiveness and safety of rivaroxaban for the prevention of thrombosis following total hip or knee replacement: A systematic review and meta-analysis.

    abstract:BACKGROUND:Prophylactic anticoagulant therapy is recommended to reduce the risk of venous thromboembolism (VTE) after total hip or knee arthroplasty, and has become the standard of care. Rivaroxaban is a novel oral medication that directly inhibits factor Xa for the prevention and treatment of thromboembolic conditions...


    pub_type: 杂志文章,meta分析


    authors: Liu J,Zhao J,Yan Y,Su J

    更新日期:2019-03-01 00:00:00

  • Manifestations and outcomes of nocardia infections: Comparison of immunocompromised and nonimmunocompromised adult patients.

    abstract::Nocardia is a ubiquitous environmental pathogen that causes infection primarily following inhalation into the lungs. It is generally thought to cause infection primarily in immunocompromised patients, but nonimmunocompromised individuals are also at risk of infection. We sought to compare risk factors, clinical manife...


    pub_type: 杂志文章


    authors: Steinbrink J,Leavens J,Kauffman CA,Miceli MH

    更新日期:2018-10-01 00:00:00

  • Evaluating the effectiveness and safety of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy: A meta-analysis (a prisma-compliant study).

    abstract:BACKGROUND:Intrahepatic cholestasis of pregnancy (ICP) is a specific pregnancy-related disorder without standard medical therapies. Ursodeoxycholic acid (UDCA) is the most used medicine, but the efficacy and safety of UDCA remain uncertain. Several meta-analyses had been made to assess the effects of UDCA in ICP. Howev...


    pub_type: 杂志文章,meta分析,评审


    authors: Kong X,Kong Y,Zhang F,Wang T,Yan J

    更新日期:2016-10-01 00:00:00

  • The efficacy of transcranial alternating current stimulation for treating post-stroke depression: Study Protocol Clinical Trial (SPIRIT Compliant).

    abstract:BACKGROUND:The treatment of post-stroke depression (PSD) with anti-depressant drugs is partly practical. Transcranial alternating current stimulation (tACS) offers the potential for a novel treatment modality for adult patients with PSD. In this study, we will assess the efficacy and safety of tACS for treating PSD and...


    pub_type: 杂志文章


    authors: Wang H,Zhang W,Zhao W,Wang K,Wang Z,Wang L,Peng M,Xue Q,Leng H,Ding W,Liu Y,Li N,Dong K,Zhang Q,Huang X,Xie Y,Chu C,Xue S,Huang L,Yao H,Ding J,Zhan S,Min B,Fan C,Zhou A,Sun Z,Yin L,Ma Q,Baskys A,

    更新日期:2020-04-01 00:00:00

  • Recommended Initial Antimicrobial Therapy for Emphysematous Pyelonephritis: 51 Cases and 14-Year-Experience of a Tertiary Referral Center.

    abstract::The aim of this study was to investigate the profiles of pathogens and patterns of antibiotic resistance of emphysematous pyelonephritis (EPN), offering recommendations for initial antibiotic treatment.Between January, 2001, and November, 2014, demographic data, presenting clinical features, management strategies, and...


    pub_type: 杂志文章


    authors: Lu YC,Hong JH,Chiang BJ,Pong YH,Hsueh PR,Huang CY,Pu YS

    更新日期:2016-05-01 00:00:00

  • Atheroma of the facial artery mimicking a parotid gland tumor: A case report.

    abstract:INTRODUCTION:Atheroma of the facial artery is an extremely rare disease. CLINICAL FINDINGS/PATIENT CONCERNS:Herein, we report an extremely rare case of an atheroma arising from the facial artery, mimicking a parotid gland tumor. DIAGNOSES:The preoperative diagnosis was a right-sided parotid gland tumor. INTERVENTION...


    pub_type: 杂志文章


    authors: Lee DH,Yoon TM,Lee JK,Lim SC

    更新日期:2016-11-01 00:00:00

  • Acupuncture for the treatment of allergic rhinitis: A systematic review protocol.

    abstract:BACKGROUND:Allergic rhinitis is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence of allergic rhinitis (AR) is increasing, resulting in a large burden of disease. Desensitizing drugs such as nasal glucocorticoids and antihistam...


    pub_type: 杂志文章


    authors: Bao H,Si D,Gao L,Sun H,Shi Q,Yan Y,Damchaaperenlei D,Li C,Yu M,Li Y

    更新日期:2018-12-01 00:00:00

  • Retrospective comparison of fludarabine in combination with intermediate-dose cytarabine versus high-dose cytarabine as consolidation therapies for acute myeloid leukemia.

    abstract::This retrospective study compared efficacy and safety of fludarabine combined with intermediate-dose cytarabine (FA regimen) versus high-dose cytarabine (HiDAC regimen) as consolidation therapy in acute myeloid leukemia (AML) patients who achieved complete remission. Disease-free survival (DFS) and overall survival (O...


    pub_type: 杂志文章


    authors: Zhang W,Ding Y,Wu H,Chen Y,Lu H,Chen C,Fu J,Wang W,Liang A,Zou S

    更新日期:2014-12-01 00:00:00

  • An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools.

    abstract::An adverse drug reactions avoidability tool called the Liverpool ADR avoidability assessment tool (LAAT) was recently developed (for research purposes), and subsequently validated with mixed interrater reliability (IRR). We investigated the comparative IRR of this tool in an inpatient cohort to ascertain its practical...


    pub_type: 杂志文章


    authors: Danjuma MI,Shokri SA,Abubeker IY,Malik AE,Abdallah IMH,Shafei MNE,Fatima H,Mahmoud M,Hussain T,Maghoub Y,Sajid J,Zouki ANE

    更新日期:2020-01-01 00:00:00

  • Reevaluation of Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma: A Meta-Analysis of Randomized Controlled Trials Over the Past 20 Years.

    abstract::The effect of neoadjuvant chemotherapy on the survival of patients with thoracic esophageal squamous cell carcinomas (ESCCs) remains controversial. The optimal management strategy for resectable ESCCs varies regionally based on local randomized controlled trials. A systematic review and meta-analysis was conducted to ...


    pub_type: 杂志文章,meta分析,评审


    authors: Zheng Y,Li Y,Liu X,Sun H,Wang Z,Zhang R

    更新日期:2015-07-01 00:00:00

  • A High Circulating Tumor Cell Count in Portal Vein Predicts Liver Metastasis From Periampullary or Pancreatic Cancer: A High Portal Venous CTC Count Predicts Liver Metastases.

    abstract::Circulating tumor cells (CTCs) released from a periampullary or pancreatic cancer can be more frequently detected in the portal than the systemic circulation and potentially can be used to identify patients with liver micrometastases. Aims of this study is to determine if CTCs count in portal venous blood of patients ...


    pub_type: 杂志文章


    authors: Tien YW,Kuo HC,Ho BI,Chang MC,Chang YT,Cheng MF,Chen HL,Liang TY,Wang CF,Huang CY,Shew JY,Chang YC,Lee EY,Lee WH

    更新日期:2016-04-01 00:00:00

  • Experiences and perceptions risk of health-care workers from coronavirus: A protocol for systematic review.

    abstract:BACKGROUND:Healthcare workers (HCWs) were at the frontline during the battle against coronavirus. Understanding and managing their fears and anxieties may hold lessons for handling future outbreaks. However, the experiences and perceptions risk of HCWs from coronavirus still remains to be controversial. Thus, the objec...


    pub_type: 杂志文章


    authors: Chen P,Lei J,Chen F,Zhou B

    更新日期:2020-05-01 00:00:00

  • Biological characteristics of 18F-FDG PET/CT imaging of cerebral alveolar echinococcosis.

    abstract::This study aims to analyze the characteristics of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for cerebral alveolar echinococcosis (CAE).Twenty-five CAE patients underwent F-FDG PET/CT, and the diagnosis was confirmed by clinical and surgical pathology. The F-FDG PET/CT results...


    pub_type: 杂志文章


    authors: Yibulayin A,Li XH,Qin YD,Jia XY,Zhang QZ,Li YB

    更新日期:2018-09-01 00:00:00

  • Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients.

    abstract:BACKGROUND AND RATIONALE:Uncertainty persists over the optimal management of blood pressure (BP) in the early phase of acute ischemic stroke (AIS). This study aims to determine the safety and effects of intensive BP lowering on cerebral blood flow (CBF) and functional in AIS patients treated with intravenous thrombolys...


    pub_type: 杂志文章,随机对照试验


    authors: Sharma VK,Tan BYQ,Sim MY,Kulkarni A,Seow PA,Hong CS,Du Z,Wong LYH,Chen J,Chee EYH,Ng BSM,Low Y,Ngiam NJH,Yeo LLL,Teoh HL,Paliwal PR,Rathakrishnan R,Sinha AK,Chan BPL,Butcher K,Anderson CS

    更新日期:2018-10-01 00:00:00

  • Balance control, agility, eye-hand coordination, and sport performance of amateur badminton players: A cross-sectional study.

    abstract::In this study, balance performance, agility, eye-hand coordination, and sports performance were compared between amateur badminton players and active controls.Thirty young adult badminton players and 33 active controls participated in the study. Static single-leg standing balance (with eyes closed) was measured using ...


    pub_type: 杂志文章


    authors: Wong TKK,Ma AWW,Liu KPY,Chung LMY,Bae YH,Fong SSM,Ganesan B,Wang HK

    更新日期:2019-01-01 00:00:00

  • Impact of different types of tree nut, peanut, and soy nut consumption on serum C-reactive protein (CRP): A systematic review and meta-analysis of randomized controlled clinical trials.

    abstract:BACKGROUND:The effects of different types of tree nut, peanut, and soy nut consumption on serum C - reactive protein (CRP) are not well established. we aimed to undertake a systematic review and meta-analysis of prospective studies to determine the effect of nut consumption (tree nuts, peanuts, and soy nuts) on serum C...


    pub_type: 杂志文章,meta分析,评审


    authors: Mazidi M,Rezaie P,Ferns GA,Gao HK

    更新日期:2016-11-01 00:00:00

  • Tigecycline in the treatment of fulminant Mycoplasma pneumoniae pneumonia non-responsive to azithromycin and fluoroquinolone: A case report.

    abstract:RATIONALE:Fulminant macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) has seldom been reported, and cases of MPP usually show rapid improvement after fluoroquinolones or tetracyclines addition. The purpose of this case report is to highlight the importance of proper selection of antibiotics for treatment of sev...


    pub_type: 杂志文章


    authors: Yuan X,Liu J,Bai C,Niu W,Wang J,Li P,Liu H,Luo Y

    更新日期:2020-07-10 00:00:00

  • Total Hemi-overgrowth in Pigmentary Mosaicism of the (Hypomelanosis of) Ito Type: Eight Case Reports.

    abstract::Pigmentary mosaicism of the (hypomelanosis of) Ito type is an umbrella term, which includes phenotypes characterized by mosaic hypopigmentation in the form of streaks, whorls, patchy, or more bizarre skin configurations (running along the lines of Blaschko): these cutaneous patterns can manifest as an isolated skin di...


    pub_type: 杂志文章


    authors: Pavone V,Signorelli SS,Praticò AD,Corsello G,Savasta S,Falsaperla R,Pavone P,Sessa G,Ruggieri M

    更新日期:2016-03-01 00:00:00

  • Validation of the Chinese version of the Mini Sarcopenia Risk Assessment questionnaire in community-dwelling older adults.

    abstract::A new sarcopenia screening tool named Mini Sarcopenia Risk Assessment (MSRA) has recently been developed, which showed a reasonable sensitivity and specificity.We cross-culturally adapted and validated the Chinese version of the MSRA in a population of community-dwelling older adults.We conducted a cross-sectional stu...


    pub_type: 杂志文章


    authors: Yang M,Hu X,Xie L,Zhang L,Zhou J,Lin J,Wang Y,Li Y,Han Z,Zhang D,Zuo Y,Li Y,Wu L

    更新日期:2018-09-01 00:00:00