A pilot study of the effect of ezetimibe for postprandial hyperlipidemia.

Abstract:

:This study aimed to explore the feasible effect of ezetimibe for postprandial hyperlipidemia (PPHP).Sixty participants were included in this study. Of these, 30 subjects in the intervention group received ezetimibe, while the remaining 30 participants in the control group did not undergo ezetimibe. All patients in intervention group were treated for a total of 2 weeks. Primary endpoints consisted of serum levels of total cholesterol (Total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG). Secondary endpoints included apoB-48, remnant lipoprotein cholesterol (RLP-C), blood glucose, insulin, hemoglobin A1c (HbA1c), and monocyte chemotactic protein (MCP). All outcomes were measured before and after 2-week treatment.After 2-week treatment, participants in the intervention group did not show better outcomes in primary endpoints of Total-C, LDL-C, HDL-C, and TG; and secondary endpoints of apoB-48, RLP-C, blood glucose, insulin, HbA1c, and MCP, compared with subjects in the control group.The results of this study showed that ezetimibe may be not efficacious for participants with PPHP after 2-week treatment.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Xue EZ,Zhang MH,Liu CL

doi

10.1097/MD.0000000000012960

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

e12960

issue

46

eissn

0025-7974

issn

1536-5964

pii

00005792-201811160-00012

journal_volume

97

pub_type

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