Therapeutic management of stroke-like episodes varies from that of encephalitis.

Abstract:

INTRODUCTION:Stroke-like episodes (SLEs) are typical cerebral manifestations of certain mitochondrial disorders (MIDs). They are characterised by a vasogenic edema in a non-vascular distribution. PATIENTS CONCERNS:: none DIAGNOSIS:: SLEs show up on cerebral MRI as stroke-like lesions (SLLs), characterised by vasogenic edema in a non-vascular distribution. SLLs expand in the acute stage and regress during the chronic stage. They show hyperperfusion in the acute stage and hypoperfusion in the chronic stage. INTERVENTIONS:SLLs respond favorably to antiseizure drugs, to No-precursors, steroids, the ketogenic diet, and antioxidants. OUTCOME:SLLs end up as normal tissue, white matter lesion, grey matter lesion, cyst, laminar cortical necrosis, or the toenail sign. CONCLUSIONS:SLLs are a frequent manifestation of MIDs. They undergo dynamic changes in the acute and chronic stage. They need to be differentiated from ischemic stroke as they are differentially treated.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Finsterer J

doi

10.1097/MD.0000000000019141

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

e19141

issue

8

eissn

0025-7974

issn

1536-5964

pii

00005792-202002210-00020

journal_volume

99

pub_type

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