Abstract:
BACKGROUND:The prognosis of gastric cancer peritoneal carcinomatosis (GCPC) remains poor despite recent advances in systemic chemotherapy (SC) with an average survival less than 6 months. Current evidence supporting the utility of hyperthermic intraperitoneal chemotherapy (HIPEC) combined with SC for GCPC is limited. We plan to provide a systematic review and meta-analysis of randomized controlled trials to evaluate the comparative effects and safety of HIPEC combined with SC in the management of GCPC. METHODS:Randomized controlled trials evaluating HIPEC combined with SC versus SC as first-line treatment for GCPC will be searched in MEDLINE, EMBASE, Web of Science, the Cochrane Library, ClinicalTrials.gov, and Google Scholar, from database inception to April 30, 2020. Data on study design, participant characteristics, intervention details, and outcomes will be extracted. Primary outcomes to be assessed are: median progression-free survival; secondary outcomes are: median survival time, 1- year survival rate, 2-year survival rate, objective response rate, and adverse events. Meta-analysis will be performed using RevMan V.5.3 statistical software. Data will be combined with a random effect model. Study quality will be assessed using the Cochrane Risk of Bias Tool. Heterogeneity will be assessed, and if necessary, a subgroup analysis will be performed to explore the source of heterogeneity. RESULTS:The results will provide useful information about the effectiveness and safety of HIPEC combined with systemic chemotherapy regimens in patients with gastric cancer peritoneal carcinomatosis. CONCLUSION:The findings of the study will be disseminated through peer-reviewed journal. THE REGISTRATION NUMBER:INPLASY202050006. DOI NUMBER:10.37766/inplasy2020.5.0006.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Lu Y,Jin Z,Zheng S,Bai Y,Sun Ydoi
10.1097/MD.0000000000020973subject
Has Abstractpub_date
2020-07-02 00:00:00pages
e20973issue
27eissn
0025-7974issn
1536-5964pii
00005792-202007020-00089journal_volume
99pub_type
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