Abstract:
:Aortic stenosis (AS) is a chronic, progressive disease predominantly affecting individuals aged over 60 years. Symptoms are the result of progressive left ventricular outflow obstruction, and herald rapid clinical decline and high mortality. Medical therapies for AS remain ineffective; operative valve replacement remains the only effective long-term treatment. We review clinical aspects of diagnosis and management of AS in adults, with attention to the natural history before and after valve replacement, assessment of suspected and established AS, and recommended management in general and in difficult clinical scenarios. We conclude with a series of 10 cases illustrating management of common, uncommon, and challenging clinical scenarios encountered at the University of Washington.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Kurtz CE,Otto CMdoi
10.1097/MD.0b013e3181fe5648subject
Has Abstractpub_date
2010-11-01 00:00:00pages
349-379issue
6eissn
0025-7974issn
1536-5964pii
00005792-201011000-00001journal_volume
89pub_type
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