Aortic stenosis: clinical aspects of diagnosis and management, with 10 illustrative case reports from a 25-year experience.

Abstract:

:Aortic stenosis (AS) is a chronic, progressive disease predominantly affecting individuals aged over 60 years. Symptoms are the result of progressive left ventricular outflow obstruction, and herald rapid clinical decline and high mortality. Medical therapies for AS remain ineffective; operative valve replacement remains the only effective long-term treatment. We review clinical aspects of diagnosis and management of AS in adults, with attention to the natural history before and after valve replacement, assessment of suspected and established AS, and recommended management in general and in difficult clinical scenarios. We conclude with a series of 10 cases illustrating management of common, uncommon, and challenging clinical scenarios encountered at the University of Washington.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Kurtz CE,Otto CM

doi

10.1097/MD.0b013e3181fe5648

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

349-379

issue

6

eissn

0025-7974

issn

1536-5964

pii

00005792-201011000-00001

journal_volume

89

pub_type

杂志文章,评审

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