Abstract:
:Qualitative and quantitative analyses of circulating cell-free DNA (cfDNA) are potential methods for the detection of hepatocellular carcinoma (HCC). Many studies have evaluated these approaches, but the results have been variable. This meta-analysis is the first to synthesize these published results and evaluate the use of circulating cfDNA values for HCC diagnosis. All articles that met our inclusion criteria were assessed using QUADAS guidelines after the literature research. We also investigated 3 subgroups in this meta-analysis: qualitative analysis of abnormal concentrations of circulating cfDNA; qualitative analysis of single-gene methylation alterations; and multiple analyses combined with alpha-fetoprotein (AFP). Statistical analyses were performed using the software Stata 12.0. We synthesized these published results and calculated accuracy measures (pooled sensitivity and specificity, positive/negative likelihood ratios [PLRs/NLRs], diagnostic odds ratios [DORs], and corresponding 95% confidence intervals [95% CIs]). Data were pooled using bivariate generalized linear mixed model. Furthermore, summary receiver operating characteristic curves and area under the curve (AUC) were used to summarize overall test performance. Heterogeneity and publication bias were also examined. A total of 2424 subjects included 1280 HCC patients in 22 studies were recruited in this meta-analysis. Pooled sensitivity and specificity, PLR, NLR, DOR, AUC, and CIs of quantitative analysis were 0.741 (95% CI: 0.610-0.840), 0.851 (95% CI: 0.718-0.927), 4.970 (95% CI: 2.694-9.169), 0.304 (95% CI: 0.205-0.451), 16.347 (95% CI: 8.250-32.388), and 0.86 (95% CI: 0.83-0.89), respectively. For qualitative analysis, the values were 0.538 (95% CI: 0.401-0.669), 0.944 (95% CI: 0.889-0.972), 9.545 (95% CI: 5.298-17.196), 0.490 (95% CI: 0.372-0.646), 19.491 (95% CI: 10.458-36.329), and 0.87 (95% CI: 0.84-0.90), respectively. After combining with AFP assay, the values were 0.818 (95% CI: 0.676-0.906), 0.960 (95% CI: 0.873-0.988), 20.195 (95% CI: 5.973-68.282), 0.190 (95% CI: 0.100-0.359), 106.270 (95% CI: 22.317-506.055), and 0.96 (95% CI: 0.94-0.97), respectively. The results in this meta-analysis suggest that circulating cfDNA have potential value for HCC diagnosis. However, it would not be recommended for using independently, which is based on the nonrobust results. After combining with AFP, the diagnostic performance will be improved. Further investigation with more data is needed.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Liao W,Mao Y,Ge P,Yang H,Xu H,Lu X,Sang X,Zhong Sdoi
10.1097/MD.0000000000000722subject
Has Abstractpub_date
2015-04-01 00:00:00pages
e722issue
14eissn
0025-7974issn
1536-5964pii
00005792-201504020-00019journal_volume
94pub_type
杂志文章,meta分析相关文献
MEDICINE文献大全abstract::Aim of this study was to determine if surface electromyography (sEMG) could provide objective data in monitoring the alteration of signal amplitude of myoelectric activity of the paraspinal muscles in the patients with acute nonspecific lower back pain (ANLBP), and to explore the correlation between sEMG data and symp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016904
更新日期:2019-08-01 00:00:00
abstract::Dysphagia can occur among patients receiving medical care despite having no history of neurologic disease. The current study aimed to investigate factors contributing to airway invasion among non-neurologically ill patients with dysphagia.This retrospective study included 52 non-neurologically ill patients who complai...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022977
更新日期:2020-11-06 00:00:00
abstract::Different patterns of milk and breast cancer rates across countries suggest that several components of milk could affect breast cancer risk. However, the components of diet are complex including milk that could potentially influence risk. Some milk products such as whole milk and cheese have a high fat content which m...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000014900
更新日期:2019-03-01 00:00:00
abstract:RATIONALE:We report a case of a hepatitis B virus (HBV)-positive patient with preexisting bone disease who developed tenofovir-induced Fanconi syndrome and subsequently sustained pathologic fracture. To our best knowledge, this is the first report in the English literature about pathologic femoral fracture due to tenof...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008760
更新日期:2017-11-01 00:00:00
abstract:AIMS:Interleukin(IL)-22 plays an important role in promoting liver regeneration and repair, but its role in chronic HBV-related liver diseasesis not clear. The goal of this study was to evaluate associations between eight IL22 single nucleotide polymorphisms (SNPs) and the development of chronic HBV cirrhosis and HBV-r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017867
更新日期:2019-11-01 00:00:00
abstract::The aim of study is to determine whether chronic osteomyelitis (COM) is linked to an increased risk of head and neck cancer (HNC).We identify 17,033 patients with osteomyelitis and 68,125 subjects without osteomyelitis during 1996 to 2010 periods. Multivariable Cox proportional hazards regression analysis was used to ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002407
更新日期:2016-01-01 00:00:00
abstract:RATIONALE:Multiple primary central nervous system lymphoma (MPCNSL) is a rare disease with differential diagnosis and treatment. As the underlying pathogenesis is not yet clarified, the early-stage clinical manifestations are occult and atypical. Also, the imaging manifestations are not specific, which is challenging f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016841
更新日期:2019-08-01 00:00:00
abstract::The aim of the study was to evaluate in human immunodeficiency virus (HIV)-infected patients estimated glomerular filtration rate (eGFR) trajectories during treatment with different protease inhibitors (PIs) or a non-nucleoside reverse transcriptase inhibitor (NNRTI) plus tenofovir (TDF) or abacavir (ABC) and lamivudi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003780
更新日期:2016-05-01 00:00:00
abstract:RATIONALE:Prepubertal unilateral gynecomastia is extremely rare, whose etiology and management strategy are not familiar. We would like to present a case and a literature review of unilateral prepubertal gynecomastia. PATIENT CONCERNS:A 11-year old male patient with complaints of unilateral enlargement of breast tissu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017374
更新日期:2019-10-01 00:00:00
abstract::Thyrotoxic periodic paralysis (TPP) is characterized by the presence of muscle paralysis, hypokalemia, and hyperthyroidism. We report the case of a young man with paralysis of the lower extremities, severe hypokalemia, and concurrent hyperthyroidism. TPP was suspected; therefore, treatment consisting of judicious pota...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001689
更新日期:2015-09-01 00:00:00
abstract::Two patients with plasma cell dyscrasias, manifested by osteosclerotic bone lesions and small amounts of M protein, and a complicating multi-system disorder are described. Their features of severe sensory-motor polyneuropathy, organomegaly, endocrine dysfunction, anasarca, elevated CSF protein, and skin hyperpigmentat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-198007000-00006
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Undiagnosed pleural effusions (UPEs) are a common problem of respiratory medicine, leading to an increased diagnostic burden globally. However, the most efficient and cost-effective approaches to UPEs remain controversial. This study aimed to assess the diagnostic value of ultrasound-guided nee...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021076
更新日期:2020-07-02 00:00:00
abstract:RATIONALE:Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries. CAE is often associated with the presence of slow coronary flow and may lead to acute myocardial infarction (AMI), even without total occlusion. PATIENT CONCERNS AND DIAGNOSIS:We report a case of a 24-year-old ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005976
更新日期:2017-01-01 00:00:00
abstract::The true survival benefit of different curative strategies involving type of operative procedure and timing for patients with initial noncurative colorectal liver metastases remains uncertain. The goal of this study was to examine the effect of primary tumor resection on patients' survival and to clarify the predictiv...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008831
更新日期:2017-12-01 00:00:00
abstract::Hexachloroethane (HC)/zinc chloride (ZnCl, smoke bomb) exposure in the military setting results in lung injury which is uncommon and has been rarely described in previous studies. The aim of this study is to investigate the correlation between the serum zinc in patients with HC/ZnCl smoke inhalation lung injury and di...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008156
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Perimenopausal insomnia (PI) is one of the most common complaints in women. Acupuncture is used to treat PI increasingly considering its less side effect. The subject of this study is to explore the effectiveness and safety of acupuncture for PI. METHODS:All the randomized controlled trials(RCT) literatures...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000011083
更新日期:2018-06-01 00:00:00
abstract::A nationwide multicenter study was conducted in the China to explore sources of variation of reference values and establish reference intervals for 28 common biochemical analytes, as a part of the International Federation of Clinical Chemistry and Laboratory Medicine, Committee on Reference Intervals and Decision Limi...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000002915
更新日期:2016-03-01 00:00:00
abstract::Unplanned reoperations have not been studied extensively in pediatric patients, especially concerning risk factors. We aim to estimate the rate of unplanned reoperations and to determine the associated factors in pediatric general surgical specialties.This analysis included a retrospective case-control study of unplan...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019982
更新日期:2020-05-01 00:00:00
abstract::The study aimed to investigate the clinical features and prognoses of patients with tuberculosis (TB) who had secondary hemophagocytic lymphohistiocytosis (HLH).Patients first presenting with fever of unknown origin, who were ultimately diagnosed with TB-associated secondary HLH, were assessed retrospectively. We summ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006575
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Previous reports found that cinnamaldehyde has effects on anti-respiratory syncytial virus (ARSV). However, their results are still contradictory. Therefore, this study will systematically address the effects of cinnamaldehyde on ARSV. METHODS:The following electronic bibliographic databases will be retriev...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000020266
更新日期:2020-05-01 00:00:00
abstract::Cardiac myxoma is a true intracardiac neoplasm, which is histologically benign but which on occasion may exhibit behavior suggestive of a true malignancy. It is the most common form of primary cardiac tumor, accounting for 50% of such neoplasms. Seventy-five percent of myxomas are found in the left atrium, typically a...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-198703000-00003
更新日期:1987-03-01 00:00:00
abstract::Bisphenol A (BPA), a carbon-based synthetic compound, exhibits hormone-like properties and is present ubiquitously in the environment and in human tissues due to its widespread use and biological accumulation. BPA can mimic estrogen to interact with estrogen receptors α and β, leading to changes in cell proliferation,...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000211
更新日期:2015-01-01 00:00:00
abstract::Dyslipidemia is one of the most important factors for coronary artery disease (CAD). The atherogenic index of plasma (AIP), a new comprehensive lipid index, might be a strong marker for predicting the risk of CAD.A hospital-based case-control study including 2936 CAD patients and 2451 controls was conducted in a Chine...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008058
更新日期:2017-09-01 00:00:00
abstract::In this study, a constant pressure stimulus was applied on the 3 joints (first [p1], second [p2], and third [p3] joints) of 4 fingers (index, middle, ring, and little fingers), and the activation areas within Brodmann area 2 (BA 2) were compared for these different fingers and joints by using functional magnetic reson...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001657
更新日期:2015-09-01 00:00:00
abstract::The purpose of this observational study was to examine the prevalence of obesity in children of 6 to 8 years of age from primary public schools over a period of 6 years and the associated environmental and metabolic health risk factors.This was a cohort observational study to investigate the prevalence of obesity in c...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015666
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Numerous studies have reported an association between cytotoxic T-lymphocyte associated antigen 4 gene (CTLA4) polymorphism and susceptibility to asthma, in different populations, but the results have been inconsistent. We performed a meta-analysis of 19 published case-control studies to obtain a reasonably ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000011380
更新日期:2018-07-01 00:00:00
abstract::The manometry with water-perfused or solid-state catheters is the predominant diagnostic procedure to detect motility disorders of the esophagus. Another method is the manometry using gas-perfused catheters. Although the high-resolution manometry is the method of first choice, the conventional manometry with helium ha...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009910
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:The infection is an essential problem in the clinical practice in orthopedics. The bibliometric analysis was conducted to evaluate the top 100 cited articles on infection in orthopaedics. METHODS:The Web of Science (WoS) Core Database was comprehensively searched from 1975 to 2017, and the literature search wa...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014067
更新日期:2019-01-01 00:00:00
abstract::The occurrence and characteristics of remissions in patients with systematic lupus erythematosus (SLE) have not been determined. We therefore studied this in a cohort of 667 patients and found that 156 patients had achieved at least 1 period of 1 year or more of treatment-free clinical remission. This represents an in...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199603000-00005
更新日期:1996-03-01 00:00:00
abstract:INTRODUCTION:Because of its infrequent and the lack of clinical data and image finding, the management of acute infections with the hepatosplenic brucella abscesses is challenging. METHODS:There were 10 serologically diagnosed cases with this brucella infection. All patients had fever, 50% patients had upper abdominal...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015881
更新日期:2019-06-01 00:00:00