Abstract:
INTRODUCTION:Intestinal pseudo-obstruction (IPO) is a rare and life-threatening complication of lupus. PATIENT CONCERNS:A patient with long-standing lupus developed recurrent abdominal pain and distension as well as nausea and emesis. DIAGNOSIS:Imaging showed dilated small bowel loops with air-fluid levels and bowel wall thickening. She also had bilateral hydronephrosis. INTERVENTIONS:She was given high-doses of intravenous steroids and cyclophosphamide. OUTCOMES:Her symptoms resolved within a week of starting immunosuppression. She was eventually transitioned to mycophenolate mofetil. She remained in remission and immunosuppression was successfully stopped after 1 year. CONCLUSIONS:Intestinal pseudo-obstruction is a rare complication of lupus that is often seen in association with ureterohydronephrosis and interstitial cystitis. This clinical syndrome is thought to be because of smooth muscle dysmotility of the gastrointestinal and genitourinary tracts, although the exact mechanism of dysmotility remains unknown. This condition is often responsive to immunosuppression if recognized and treated promptly.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Adler BL,Timlin H,Birnbaum Jdoi
10.1097/MD.0000000000016178subject
Has Abstractpub_date
2019-07-01 00:00:00pages
e16178issue
28eissn
0025-7974issn
1536-5964pii
00005792-201907120-00013journal_volume
98pub_type
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