Lupus intestinal pseudo-obstruction and hydronephrosis: Case report.

Abstract:

INTRODUCTION:Intestinal pseudo-obstruction (IPO) is a rare and life-threatening complication of lupus. PATIENT CONCERNS:A patient with long-standing lupus developed recurrent abdominal pain and distension as well as nausea and emesis. DIAGNOSIS:Imaging showed dilated small bowel loops with air-fluid levels and bowel wall thickening. She also had bilateral hydronephrosis. INTERVENTIONS:She was given high-doses of intravenous steroids and cyclophosphamide. OUTCOMES:Her symptoms resolved within a week of starting immunosuppression. She was eventually transitioned to mycophenolate mofetil. She remained in remission and immunosuppression was successfully stopped after 1 year. CONCLUSIONS:Intestinal pseudo-obstruction is a rare complication of lupus that is often seen in association with ureterohydronephrosis and interstitial cystitis. This clinical syndrome is thought to be because of smooth muscle dysmotility of the gastrointestinal and genitourinary tracts, although the exact mechanism of dysmotility remains unknown. This condition is often responsive to immunosuppression if recognized and treated promptly.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Adler BL,Timlin H,Birnbaum J

doi

10.1097/MD.0000000000016178

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

e16178

issue

28

eissn

0025-7974

issn

1536-5964

pii

00005792-201907120-00013

journal_volume

98

pub_type

杂志文章

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