Abstract:
:Indentation hardness test is a good in vitro method of bone quality assessment. The purpose of this study is to explore the distribution characteristics of bone tissue microhardness in tibial diaphysis and provide theoretical support for the test site selection of the reference point indentation technique.Three fresh right tibias were obtained from 3 cadaver donors. The tibial diaphysis was evenly divided into 6 sections. Bone specimens with a thickness of 3 mm were cut from each part. After appropriate management, micro-indentation tests were performed in various regions of the specimens to acquire the microhardness values of the tibial diaphysis. Statistical analysis was performed by randomized block design variance analysis to study the distribution characteristics of bone microhardness.72 regions were selected for 360 effective indentations. We found that the bone microhardness is inhomogeneous in tibia diaphysis. Mean hardness value of the anterior, medial, posterior, lateral region of tibia diaphysis was 45.58 ± 4.39 Vickers hardness (HV), 52.33 ± 3.93 HV, 54.00 ± 4.21 HV, 52.89 ± 4.44 HV, respectively. The anterior cortex exhibits lower microhardness value than the other regions (P < .001). Within the same region, microhardness varies significantly with positions in the tibial diaphysis. The variations in indentation hardness are bound to have a significant impact on the comparability of different reference point indentation (RPI) studies.The results of this study indicated the regional microhardness difference in the human tibia diaphysis. The microhardness of different planes in the same region is also inconsistent. Inhomogeneous distribution of indentation microhardness would have considerable influence in the test site selection of RPI technique. The data collected in our study would contribute to the design of highly precise 3D printing implants and bionic bones with gradient elastic modulus.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wang J,Yin B,Liu G,Li S,Zhang X,Hu Z,Wu W,Zhang Ydoi
10.1097/MD.0000000000016523subject
Has Abstractpub_date
2019-07-01 00:00:00pages
e16523issue
29eissn
0025-7974issn
1536-5964pii
00005792-201907190-00065journal_volume
98pub_type
杂志文章相关文献
MEDICINE文献大全abstract:OBJECTIVE:Previous studies have shown that microRNA-25 (miR-25) plays a key role in the occurrence and development of non-small cell lung cancer (NSCLC). Many studies have shown that there is a significant increment of miR-25 in circulating blood of patients with NSCLC. The meta-analysis aims to explore diagnostic valu...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000023425
更新日期:2020-12-18 00:00:00
abstract:INTRODUCTION:Because of its infrequent and the lack of clinical data and image finding, the management of acute infections with the hepatosplenic brucella abscesses is challenging. METHODS:There were 10 serologically diagnosed cases with this brucella infection. All patients had fever, 50% patients had upper abdominal...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015881
更新日期:2019-06-01 00:00:00
abstract::Systemic activation of hemostasis and thrombosis has been implicated in tumor progression and metastasis. D-dimer has been used as an indicator for the thrombosis. Here, we investigated the role of the activation of coagulation in patients with metastatic gastric cancer by measuring D-dimer level.We conducted an obser...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000951
更新日期:2015-07-01 00:00:00
abstract::Proteinuria is a major determinant of adverse renal outcome, and its reduction slows renal progression in glomerular diseases. However, the optimal target of proteinuria in glomerular diseases is unclear, and discrepancies in the definition of proteinuria produce ambiguous findings. Here we investigated the optimal ta...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008154
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The requirement of postoperative bedridden and immobilization renders neurosurgical patients with higher risk of deep vein thrombosis (DVT), then more vulnerable for pulmonary thromboembolism (PTE). But silent pulmonary thromboembolism (SPTE) can be the very early stage of any typical form of PTE, its diagno...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000004589
更新日期:2016-08-01 00:00:00
abstract::Conventional methods for identifying gastroenteritis pathogens are time consuming, more likely to result in a false-negative, rely on personnel with diagnostic expertise, and are dependent on the specimen status. Alternatively, molecular diagnostic methods permit the rapid, simultaneous detection of multiple pathogens...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011006
更新日期:2018-06-01 00:00:00
abstract::Mutation analysis as the gold standard is particularly important in diagnosis of osteogenesis imperfecta (OI) and it may be preventable upon early diagnosis. In this study, we aimed to analyze the clinical and genetic materials of an OI pedigree as well as to confirm the deleterious property of the mutation.A pedigree...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007783
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Premature ejaculation (PE) affects 8% to 30% of adult men worldwide. Recently, the incidence of PE is on the rise. A series of prior studies suggested that the incidence of PE is related to various biological factors as low testosterone, low serum vitamin D, diabetes, lower urinary tract symptoms, and othe...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021866
更新日期:2020-08-21 00:00:00
abstract::The relationship between the prevalence of chronic diseases and income level has now become a main theme in poor national economic situations. We examined the prevalence of well-controlled chronic diseases according to income level. Data from the 2008 to 2014 Korea National Health and Nutrition Examination Survey, con...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005286
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:Metastatic neuroblastoma (NB) is an aggressive malignancy with a poor prognosis. Many patients present with relapsed high-risk NB after undergoing first-line treatment, and there is no standard therapy available in this setting. PATIENT CONCERNS:The present study aimed to present the cases of 2 patients w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020896
更新日期:2020-06-26 00:00:00
abstract:INTRODUCTION:Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000007484
更新日期:2017-07-01 00:00:00
abstract::In a retrospective analysis of 40 hospitalized patients with the Guillain-Barré syndrome (GBS), we related the use and outcome of assisted ventilation to specific quantitative details of the neurologic illness. Two patients had an unusually prolonged course: they were ventilated for 374 and 396 days before successful ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-198509000-00005
更新日期:1985-09-01 00:00:00
abstract::It is known that many medical adverse events can be caused by nonsteroidal anti-inflammatory drugs (NSAIDs); however, epidemiologic evidence has not granted an affirmative relationship between NSAID use and the risk of end-stage renal disease (ESRD). We aimed to investigate the relationship in a Chinese population bet...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001362
更新日期:2015-09-01 00:00:00
abstract::To provide a basis for disease prevention, this article aimed to clarify the incidence and risk factors of traumatic fractures in China.The China National Fracture Study (CNFS) was a retrospective epidemiological study that recruited a nationally representative sample from 8 provinces, 24 urban cities, and 24 rural co...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012190
更新日期:2018-08-01 00:00:00
abstract::The long-term cardiovascular outcomes of a population-based cohort presenting to the emergency department (ED) with chest pain and classified with a clinical risk stratification algorithm are not well documented. The Olmsted County Chest Pain Study is a community-based study that included all consecutive patients pres...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e3181b98782
更新日期:2009-09-01 00:00:00
abstract:RATIONALE:We present a rare case of a traumatic intradural ruptured disc associated with a mild vertebral body compression fracture along with a review of the relevant medical literature. An intradural ruptured disc often occurs due to chronic degenerative diseases and is rarely due to trauma. It can cause irreversible...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019037
更新日期:2020-02-01 00:00:00
abstract::Teenage mothers are at high risk for maternal and neonatal complications. This study aimed to evaluate the socioeconomic circumstances of teenage pregnancy, and determine whether these increased risks remained after adjustment for socioeconomic circumstances in Korea. Using the National Health Insurance Corporation da...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004630
更新日期:2016-08-01 00:00:00
abstract:RATIONALE:The occurrence of hyperkalemia after esophagectomy is clinically rare. Patients who underwent esophagectomy often have a serum potassium level due to perioperative reduced intake, fluids loss, consumption and other reasons. These patients often require the artificial administration of potassium. Rapid fluid l...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008966
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:Penile metastasis in rectal cancer is very rare and often originates from prostatic or bladder cancer. The prognosis of penile metastasis is poor and its treatments are more often palliative than curative due to association with disseminated metastases. Pathologic complete response (pCR) in rectal cancer with...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021215
更新日期:2020-07-17 00:00:00
abstract::The mixed convolution kernel alters his properties geographically according to the depicted organ structure, especially for the lung. Therefore, we compared the image quality of the mixed convolution kernel to standard soft and hard kernel reconstructions for different organ structures in thoracic computed tomography ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005309
更新日期:2016-11-01 00:00:00
abstract:RATIONALE:The ischemic penumbra assessment is essential for the subsequent therapy and prediction of evolution in patients with acute ischemic infraction. Although controversial as a perfect equivalence to penumbra, perfusion-weighted imaging (PWI)-diffusion-weighted imaging (DWI) mismatch may predict the response to t...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006091
更新日期:2017-02-01 00:00:00
abstract::The objective of this study was to develop a venous computed tomography (CT)-based radiomics model to predict the lymph node metastasis (LNM) in patients with non-small cell lung cancer (NSCLC). A total of 411 consecutive patients with NSCLC underwent tumor resection and lymph node (LN) dissection from January 2018 to...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020074
更新日期:2020-05-01 00:00:00
abstract::Genetic etiology hypothesis is widely accepted in the development of congenital scoliosis (CS). The delta-like 3 (DLL3) gene, a member of the Notch signaling pathway, was implicated to contribute to human CS. In this study, a case-control association study was conducted to determine the association of single nucleotid...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004347
更新日期:2016-07-01 00:00:00
abstract::To investigate the incidence and pattern of child and adolescent (≤18 years old) traumatic fractures (TFs) as a result of collisions.We retrospectively reviewed 270 child and adolescent patients (228 males and 42 females aged 12.8 ± 5.1 years old) with TFs as a result of collisions admitted to our university-affiliate...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010821
更新日期:2018-05-01 00:00:00
abstract::This study used a system evaluation method to summarize China's experience on improving the coverage of hepatitis B vaccine, especially the strategies employed to improve the uptake of timely birth dosage. Identifying successful methods and strategies will provide strong evidence for policy makers and health workers i...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000003693
更新日期:2016-05-01 00:00:00
abstract:RATIONALE:Primary end-to-end anastomosis is common in adult trachea resection. Nevertheless, considering that the utilization of grafts is still essential for restoring defect in long-segment tracheal resection surgery, long-segment tracheal resection and reconstruction still remain challenging. Herein we present a nov...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017871
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The patient's pattern identification has been used for personalized medicine in traditional Korean medicine (TKM) and aims for patient-specific therapy by Korean medical doctors. The pattern identification in this trial will be diagnosed from body constitution questionnaire (BCQ) with a more objective diagno...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016035
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Numerous studies have reported an association between cytotoxic T-lymphocyte associated antigen 4 gene (CTLA4) polymorphism and susceptibility to asthma, in different populations, but the results have been inconsistent. We performed a meta-analysis of 19 published case-control studies to obtain a reasonably ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000011380
更新日期:2018-07-01 00:00:00
abstract::Fatty acid (FA) composition is closely associated with tumorigenesis and neoplasm metastasis. This study was designed to investigate the differences of phospholipid FA (PLFA) composition in erythrocyte and platelet cell membranes in both gastrointestinal (GI) tumor patients and healthy controls.In this prospective stu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007189
更新日期:2017-06-01 00:00:00
abstract::We present 11 patients with immunotactoid glomerulopathy, a new syndrome characterized clinically by proteinuria (11/11), microscopic hematuria (9/11) and hypertension (9/11). The patients consisted of six females and five males, aged 25 to 59 years (mean, 44.6). Proteinuria was the presenting feature and the reason f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-198507000-00004
更新日期:1985-07-01 00:00:00