Abstract:
RATIONALE:The ischemic penumbra assessment is essential for the subsequent therapy and prediction of evolution in patients with acute ischemic infraction. Although controversial as a perfect equivalence to penumbra, perfusion-weighted imaging (PWI)-diffusion-weighted imaging (DWI) mismatch may predict the response to thrombolysis. Due to the reliance of PWI on contrast agents, noninvasive alternatives remain an unmet need. PATIENT CONCERNS:We reported a 65-year-old man complained of paroxysmal hemiplegia of his right limbs and anepia for 2 days, whereas the symptoms lasted for about 12 hours when he admitted to the hospital. DIAGNOSIS:We diagnosed it as acute ischemic stroke caused by the left middle cerebral artery stenosis. INTERVENTIONS:Susceptibility-weighted imaging (SWI), multimodal magnetic resonance imaging (MRI) work-up which includes conventional MRI sequences (T1WI, T2WI, and FLAIR), DWI, PWI. OUTCOMES:His DWI-SWI mismatch was comparable to that of DWI-PWI at admission, suggesting that DWI-SWI could predict ischemic penumbra in patient with acute infarction. He refused the digital subtraction angiography examination or stenting, and he was treated with aspirin, atorvastain, and supportive treatment. The patient received a reexamination of the conventional MRI and SWI 11 days later. Expansion of the infarction in the affected MCA territory resulted from the penumbra indicated by the mismatch between DWI-SWI. LESSONS:SWI can be used as a noninvasive alternative to evaluate the ischemic penumbra. Besides, SWI can provide perfusion information comparable to PWI and SWI is sufficient to identify occlusive arteries.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wu X,Luo S,Wang Y,Chen Y,Liu J,Bai J,Feng J,Zhang Hdoi
10.1097/MD.0000000000006091subject
Has Abstractpub_date
2017-02-01 00:00:00pages
e6091issue
6eissn
0025-7974issn
1536-5964pii
00005792-201702100-00051journal_volume
96pub_type
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