Abstract:
INTRODUCTION:Metastatic neuroblastoma (NB) is an aggressive malignancy with a poor prognosis. Many patients present with relapsed high-risk NB after undergoing first-line treatment, and there is no standard therapy available in this setting. PATIENT CONCERNS:The present study aimed to present the cases of 2 patients with recurrent high-risk NB. DIAGNOSIS:Two children with International Neuroblastoma Stage System stage 4 high-risk NB chemotherapy. The disease recurrent after finishing the treatment. INTERVENTIONS:Both patients (34 months old and 41 months old) experienced recurrence, received second-line treatment, and then received maintenance treatment using apatinib plus retinoic acid. The apatinib (10 mg/kg per day) and retinoic acid (160 mg/m per day) were administered on alternating 2-week cycles, which was continued for 1 year. OUTCOMES:The 2 patients had achieved complete response by the 1-year follow-up after starting apatinib plus retinoic acid, and did not experience any adverse drug reactions. CONCLUSION:The outcomes from these cases suggest that apatinib plus isotretinoin might be an option for maintenance therapy in patients with recurrent high-risk NB.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Jin M,Zhang D,Zhao Q,Zhao W,Huang C,Wang X,Duan C,Su Y,Ma Xdoi
10.1097/MD.0000000000020896subject
Has Abstractpub_date
2020-06-26 00:00:00pages
e20896issue
26eissn
0025-7974issn
1536-5964pii
00005792-202006260-00075journal_volume
99pub_type
杂志文章相关文献
MEDICINE文献大全abstract::This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecuti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012578
更新日期:2018-10-01 00:00:00
abstract::(Sca) is a ubiquitous filamentous fungus capable of causing invasive disease. We reviewed our electronic microbiology records and the English-language literature. Between 1976 and December 1999 we identified 23 solid organ transplant recipients with Sca infection, 7 of which occurred between December 1987 and December...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-200209000-00001
更新日期:2002-09-01 00:00:00
abstract::There is currently a lack of reliable, reproducible, and easily applied methods for assessing changes in liver histology in patients in the gray zone phase of chronic hepatitis B (CHB). Therefore, we aimed to develop a novel predictive scoring system to detect significant liver histological changes in these patients.A...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006465
更新日期:2017-04-01 00:00:00
abstract::Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000003079
更新日期:2016-03-01 00:00:00
abstract::Central nervous system (CNS) nocardiosis is a rare disease entity caused by the filamentous bacteria Nocardia species. We present a case series of 5 patients from our hospital and a review of the cases of CNS nocardiosis reported in the literature from January 2000 to December 2011. Our results indicate that CNS nocar...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000000012
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:To investigate the effect of neck-specific exercise with (NSEB) or without (NSE) a behavioural approach and prescribed physical activity (PPA) on general pain disability and psychological factors in chronic whiplash-associated disorders (WAD), grade 2 and 3, with a 2-year follow-up. METHODS:A randomized con...
journal_title:Medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/MD.0000000000004430
更新日期:2016-08-01 00:00:00
abstract:RATIONALE:Congenital myasthenic syndrome (CMSs) are a group of rare genetic disorders of the neurological junction, which can result in structural or functional weakness. Here, we characterized a case of CMS in order to clarify the diagnosis and expand the understanding of it. The molecular diagnosis had implications f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010347
更新日期:2018-04-01 00:00:00
abstract::To examine the characteristics and short-term outcome of perioperative myocardial infarction (PMI), a single-center retrospective study was carried out. The electronic medical records of 278,939 patients aged 45 years or older who underwent non-cardiac surgery at Renji Hospital from January 2003 to December 2015 were ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016929
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Preoperative anxiety is known to be related with the postoperative outcomes, although it remains unclear whether pharmacologic anxiolysis preoperatively leads to better postanesthesia recovery. Hence, the purpose of this study was to assess whether midazolam premedication would result in improved Quality of ...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000006107
更新日期:2017-02-01 00:00:00
abstract::We initiated a prospective study with a group of practitioners to assess the etiology, clinical presentation, and outcome of community-acquired pneumonia in patients diagnosed in the outpatient setting. All patients with signs and symptoms suggestive of pneumonia and an infiltrate on chest X-ray underwent an extensive...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-200103000-00001
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Percutaneous tracheostomy, almost associated with cough reflex and hemodynamic fluctuations, is a common procedure for traumatic brain injury (TBI) patients, especially those in neurosurgery intensive care units (NICUs). However, there are currently a lack of effective preventive measures to reduce the risk ...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000017012
更新日期:2019-08-01 00:00:00
abstract::Patients with persistent or recurrent trigeminal neuralgia (TN) after microvascular decompression (MVD) are frequently difficult to manage. This study aimed to analyze the safety and efficiency of repeat MVD, with the main focus on prognostic factors and long-term outcomes.We performed a retrospective study of 41 TN p...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015167
更新日期:2019-05-01 00:00:00
abstract::As surgeries are performed around the clock, the time of surgery might have an impact on outcomes. Our aim is to investigate the impact of daytime and nighttime shifts on surgeons and their performance. We believe that such studies are important to enhance the quality of surgeries and their outcomes and help understan...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020273
更新日期:2020-08-07 00:00:00
abstract::Thyroid complications resulting from excess iodide such as thyrotoxicosis, thyroiditis, sialadenitis, or hypothyroidism are much rarer after iodine supplementation with Lipiodol than with KI. They do not militate against its widespread use in endemic goiter populations, especially in pregnant women. However, patients ...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-200101000-00003
更新日期:2001-01-01 00:00:00
abstract::School sandplay group therapy is a useful clinical treatment method for adolescents who cannot adapt to school due to various emotional and behavioral problems. In this study, we conducted 10 weeks of group therapy in 70 adolescents referred to as maladjustment behavior problem in the school. The purpose of this study...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023272
更新日期:2020-12-11 00:00:00
abstract:RATIONALE:Mirizzi syndrome (MS) is an uncommon condition characterized by common hepatic duct (CHD) compression by an impacted gallbladder or cystic duct stones or adjacent inflammation. To date, a standardized therapeutic strategy for MS has not been established yet, owing to its complex clinical presentation. Thus, r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022649
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:Long-term use of aspirin for primary prevention of cancer remains inconclusive, and variation in the effects of aspirin use on cancer outcomes by cancer site, aspirin dose, follow-up duration, or different populations has never been systematically evaluated. METHODS:Seven electronic databases (PubMed, EMBAS...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017382
更新日期:2019-09-01 00:00:00
abstract::Risk factors for chronic kidney disease (CKD), such as hypertension, hyperglycemia, albuminuria, renal structure, and sex hormones, have been reported to have different effects on males and females. Thus, CKD progression may differ depending on sex. In addition to CKD management, treatment at earlier stages can reduce...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004203
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:This randomized controlled trial (RCT) aimed to compare the clinical outcomes of thoracolumbar burst fractures (TLBFs) treated with open reduction and internal fixation via the posterior paraspinal muscle approach (PPMA) and the post-middle approach (PA). METHODS:Patients with a traumatic single-level TLBFs...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000011193
更新日期:2018-06-01 00:00:00
abstract:RATIONALE:Tooth extraction is a common dental surgical procedure. There is a possibility that various complications often occur during third molar tooth extractions. PATIENT CONCERNS:The authors report herein 2 cases of migration of a high-speed dental hand-piece bur during mandibular third molar extraction-one case w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019177
更新日期:2020-02-01 00:00:00
abstract::We retrospectively analyzed the long-term outcome of idiopathic pulmonary hemosiderosis (IPH) in 15 children. IPH started at a mean age of 5 years, and the mean duration of follow-up was 17.2 years (range, 10-36 yr). Four patients developed immune disorders, 3 cases of rheumatoid polyarthritis or rheumatoid polyarthri...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-200009000-00005
更新日期:2000-09-01 00:00:00
abstract::Exogenous administration of coenzyme Q10 (CoQ10) has been shown in experimental models to have a protective effect against ischemia-reperfusion injury. However, it is unclear whether follow-up plasma CoQ10 concentration is prognostic of left ventricular (LV) performance after primary balloon angioplasty in patients wi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004501
更新日期:2016-08-01 00:00:00
abstract::No previous study has used an ultrasonic cardiac output monitor (USCOM) to assess volume parameters, such as stroke volume variation (SVV), in order to predict the volume status and fluid responsivenes in children after congenital heart disease (CHD) surgery. The present prospective trial aimed to investigate the abil...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000012289
更新日期:2018-09-01 00:00:00
abstract::IgG4-related disease (IgG4-RD) is a novel systemic disease entity characterized by elevated serum IgG4 and tissue infiltration of IgG4-positive plasma cells accompanied by severe fibrosis. Although recent studies demonstrated that innate immune cells including monocytes and macrophages might promote local fibrosis and...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002853
更新日期:2016-02-01 00:00:00
abstract::Increasing numbers of patients with different types of dementia have resulted in the increasing medical care loads. It is not known whether explanatory factors for recurrent or prolong hospitalization were driven by the subtypes of dementia. We analyzed 203 dementia patients aged >65-year-old with a clinical diagnosis...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002091
更新日期:2015-11-01 00:00:00
abstract:RATIONALE:Ossifying fibroma is benign fibro-osseous neoplasm. The authors report a case of ossifying fibroma in the mandibular angle suspected as metastasis of clear cell renal cell carcinoma. PATIENT CONCERNS:A 74-year-old man presented to the primary hospital complaining of frequent urination. A tumor in the left ki...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016595
更新日期:2019-08-01 00:00:00
abstract::The purpose of this retrospective study is to show that transcervical diverticulectomy (TD) in treatment of Zenker diverticulum (ZD) can still be a first choice procedure in selected patients and in experienced hands its safety might be compared to the minimally invasive endoscopic diverticulostomy.The study cohort co...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010557
更新日期:2018-05-01 00:00:00
abstract::Despite the wide recognition of the inverse association between socioeconomic position (SEP) and suicidal behaviors, its underlying process and potential mediators are little known. This study investigated the pathway from SEP to suicide attempts with attention to potential mediators.From the Korean Health and Nutriti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009331
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:Well-differentiated liposarcomas (WDLPS) are rare retroperitoneal tumors that can reach significant size as they can grow without constrains before becoming symptomatic. Laparotomic open radical tumor resection represents the most common surgical approach. PATIENT CONCERNS:A mass with "fat fluid level" was f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015184
更新日期:2019-04-01 00:00:00
abstract::Bleedings represent most relevant complications being correlated with significant rates of adverse clinical outcomes in patients undergoing percutaneous coronary intervention (PCI). To reduce bleeding and improve prognosis various types of vascular closure devices (VCD) are frequently applied. This study aims to compa...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015501
更新日期:2019-05-01 00:00:00