Apatinib plus retinoic acid as maintenance for children with relapsed stage 4 high-risk neuroblastoma: Two case reports.

Abstract:

INTRODUCTION:Metastatic neuroblastoma (NB) is an aggressive malignancy with a poor prognosis. Many patients present with relapsed high-risk NB after undergoing first-line treatment, and there is no standard therapy available in this setting. PATIENT CONCERNS:The present study aimed to present the cases of 2 patients with recurrent high-risk NB. DIAGNOSIS:Two children with International Neuroblastoma Stage System stage 4 high-risk NB chemotherapy. The disease recurrent after finishing the treatment. INTERVENTIONS:Both patients (34 months old and 41 months old) experienced recurrence, received second-line treatment, and then received maintenance treatment using apatinib plus retinoic acid. The apatinib (10 mg/kg per day) and retinoic acid (160 mg/m per day) were administered on alternating 2-week cycles, which was continued for 1 year. OUTCOMES:The 2 patients had achieved complete response by the 1-year follow-up after starting apatinib plus retinoic acid, and did not experience any adverse drug reactions. CONCLUSION:The outcomes from these cases suggest that apatinib plus isotretinoin might be an option for maintenance therapy in patients with recurrent high-risk NB.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Jin M,Zhang D,Zhao Q,Zhao W,Huang C,Wang X,Duan C,Su Y,Ma X

doi

10.1097/MD.0000000000020896

subject

Has Abstract

pub_date

2020-06-26 00:00:00

pages

e20896

issue

26

eissn

0025-7974

issn

1536-5964

pii

00005792-202006260-00075

journal_volume

99

pub_type

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