Abstract:
:The objective of this study was to develop a venous computed tomography (CT)-based radiomics model to predict the lymph node metastasis (LNM) in patients with non-small cell lung cancer (NSCLC). A total of 411 consecutive patients with NSCLC underwent tumor resection and lymph node (LN) dissection from January 2018 to September 2018 in our hospital. A radiologist with 20 years of diagnostic experience retrospectively reviewed all CT scans and classified all visible LNs into LNM and non-LNM groups without the knowledge of pathological diagnosis. A logistic regression model (radiomics model) in classification of pathology-confirmed NSCLC patients with and without LNM was developed on radiomics features for NSCLC patients. A morphology model was also developed on qualitative morphology features in venous CT scans. A training group included 288 patients (99 with and 189 without LNM) and a validation group included 123 patients (42 and 81, respectively). The receiver operating characteristic curve was performed to discriminate LNM (+) from LNM (-) for CT-reported status, the morphology model and the radiomics model. The area under the curve value in LNM classification on the training group was significantly greater at 0.79 (95% confidence interval [CI]: 0.77-0.81) by use of the radiomics model (build by best 10 features in predicting LNM) compared with 0.51 by CT-reported LN status (P < .001) or 0.66 (95% CI: 0.64-0.68) by morphology model (build by tumor size and spiculation) (P < .001). Similarly, the area under the curve value on the validation group was 0.73 (95% CI: 0.70-0.76) by the radiomics model, compared with 0.52 or 0.63 (95% CI: 0.60-0.66) by the other 2 (both P < .001). A radiomics model shows excellent performance for predicting LNM in NSCLC patients. This predictive radiomics model may benefit patients to get better treatments such as an appropriate surgery.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Cong M,Yao H,Liu H,Huang L,Shi Gdoi
10.1097/MD.0000000000020074subject
Has Abstractpub_date
2020-05-01 00:00:00pages
e20074issue
18eissn
0025-7974issn
1536-5964pii
00005792-202005010-00052journal_volume
99pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Prolonged inspiratory to expiratory (I:E) ratio ventilation has been researched to reduce lung injury and improve oxygenation in surgical patients with one-lung ventilation (OLV) or carbon dioxide (CO2) pneumoperitoneum. We aimed to confirm the efficacy of the 1:1 equal ratio ventilation (ERV) compared with the 1:2 co...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000003269
更新日期:2016-03-01 00:00:00
abstract::Thyroid complications resulting from excess iodide such as thyrotoxicosis, thyroiditis, sialadenitis, or hypothyroidism are much rarer after iodine supplementation with Lipiodol than with KI. They do not militate against its widespread use in endemic goiter populations, especially in pregnant women. However, patients ...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-200101000-00003
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:Based on existing literature, the juxtaglomerular cell tumor (JGCT) is a rare renal tumor, typically present with hypertension and hypokalemia. Nonfunctioning JGCT, without hypertension or hypokalemia, is extremely rare. PATIENT CONCERNS:Herein, we report a case of nonfunctioning JGCT mimicking renal cell...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022057
更新日期:2020-09-04 00:00:00
abstract::Although it is an invasive and unpleasant procedure, esophagogastroduodenoscopy (EGD) is still the gold standard for esophageal varices (EV) detection. The aim of this study was to investigate liver stiffness measurement (LSM) and spleen diameter as simple noninvasive tools for EV prediction in chronic hepatitis C pat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008621
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:To assess the safety and efficacy of percutaneous short-segment pedicle instrumentation compared with conventionally open short-segment pedicle instrumentation and provide recommendations for using these procedures to treat thoracolumbar fractures. METHODS:The Medline database, Cochrane database of Systemat...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000012535
更新日期:2018-10-01 00:00:00
abstract:RATIONALE:Capecitabine (CAP) is a chemotherapeutic agent used to treat breast and gastrointestinal cancers. The most common adverse reactions of CAP primarily included gastrointestinal and dermatological effects. Whereas, the CAP-induced fatty liver had never been reported. PATIENT CONCERNS:In this study, a-69-year ol...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008547
更新日期:2017-11-01 00:00:00
abstract:RATIONALE:Penile metastasis in rectal cancer is very rare and often originates from prostatic or bladder cancer. The prognosis of penile metastasis is poor and its treatments are more often palliative than curative due to association with disseminated metastases. Pathologic complete response (pCR) in rectal cancer with...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021215
更新日期:2020-07-17 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000005376.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/MD.0000000000006196
更新日期:2017-02-17 00:00:00
abstract::Serum adiponectin levels have been suggested to be predictors of type 2 diabetes mellitus in diverse populations. However, the relationship between circulating adiponectin levels and the risk of development of type 2 diabetes in postmenopausal women has not been investigated.A total of 382 healthy postmenopausal women...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001347
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Pulse oximetry screening is a highly accurate tool for the early detection of critical congenital heart disease (CCHD) in newborn infants. As the technique is simple, noninvasive, and inexpensive, it has potentially significant benefits for developing countries. The aim of this study is to provide informatio...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008683
更新日期:2017-11-01 00:00:00
abstract:UNLABELLED:Tubulointerstitial fibrosis and tubular atrophy play a crucial role in the pathogenesis of chronic kidney disease (CKD). They are also major determinants in chronic kidney disease development and progression in patients with primary renal diseases characterized by persistent or recurrent proteinuria. The pur...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001746
更新日期:2015-10-01 00:00:00
abstract::A single-center retrospective analysis of 46 patients with Lenke 5 adolescent idiopathic scoliosis (AIS).To compare Cobb angle distribution in different segments of the main thoracolumbar/lumbar curve in patients with Lenke 5 AIS, and differences in the lateral-bending flexibility, the correction rate, and correction ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011216
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Chronic low back pain (CLBP) is a clinically common and recurrent disease. However, many trials have shown that auriculotherapy (AT) can effectively treat CLBP. There are currently no systematic reviews of this therapy. The plan aims to evaluate the effectiveness and safety of this treatment in patients with...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019722
更新日期:2020-04-01 00:00:00
abstract::Globalization has attracted much attention to universities over the past decade. The aim of this study was to evaluate the effect of the United States-China international pharmacy education programs (IPEP) in China.Kirkpatrick's model of evaluation was used to evaluate IPEP from reaction and learning levels. In the re...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020945
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:Although robot-assisted distal pancreatectomy (RADP) has been successfully performed since 2003, its advantages over open distal pancreatectomy (ODP) are still uncertain. The objective of this meta-analysis is to compare the clinical and oncologic safety and efficacy of RADP vs ODP. METHODS:Multiple databas...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000020435
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:Chronic heart failure (CHF), the final phase of various heart diseases, is a serious public health problem resulting in high hospitalization rates, mortality, and increasing health care costs. Nuanxin capsule (NXC), a Chinese herbal formula, has been widely used in the treatment of CHF. However, the safety a...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000011339
更新日期:2018-07-01 00:00:00
abstract:RATIONALE:Epithelioid trophoblastic tumor (ETT) is a very rare form of gestational trophoblastic disease (GTD) which arises from neoplastic proliferation of intermediate trophoblasts. Metastatic ETT of the lung is extremely rare in postmenopausal women. PATIENT CONCERNS:Here we describe a 50-year-old woman with a meta...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010306
更新日期:2018-04-01 00:00:00
abstract::The purpose of this study was to determine the trends in consumption of antibiotics and evaluate the antibiotic prescription rates in the pediatric population in Lithuania during 2003 to 2012.A cross-sectional study. Data of systemic antibiotic use in pediatric population for outpatient treatment was derived from Nati...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017220
更新日期:2019-11-01 00:00:00
abstract:INTRODUCTION:Accessory liver lobe (ALL), an autonomous island of normal liver parenchyma, is a rare congenital anomaly that is difficult for preoperative diagnosis and often identified incidentally. It can also be accompanied with benign or malignant diseases, which is extremely rare. There are only 3 cases of focal no...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000021357
更新日期:2020-07-24 00:00:00
abstract:INTRODUCTION:Henoch-Schönlein purpura nephritis (HSPN) involves the renal impairment of Henoch-Schönlein purpura and can easily relapse into life-threatening late nephropathy in severe cases. Although there is a lack of validated evidence for its effectiveness, Chinese herbal medicine (CHM) is one of the most commonly ...
journal_title:Medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/MD.0000000000011064
更新日期:2018-06-01 00:00:00
abstract::Acute respiratory tract infection (ARTI) is the most common causes of outpatient visit and hospital admission for children. The study aimed to report epidemiological data on respiratory viruses in a university-affiliated children's hospital.The study was a retrospective study conducted in a university affiliated child...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011385
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION:Substantial advances in cardiac pacing technology have been developed in the past decades. However, efforts to improve pacing technology to achieve physiological electrical activity, such as with cardiac resynchronization therapy, are underway. Permanent His bundle pacing, which directly stimulates the His...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021097
更新日期:2020-08-14 00:00:00
abstract::This study aimed to assess the efficacy of allograft in 2-level anterior cervical discectomy and fusion (ACDF) with plate fixation by comparing its clinical and radiological outcomes to those of autograft.Thirty five patients with femur cortical allografts and 32 patients with tricortical iliac autografts were evaluat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016621
更新日期:2019-08-01 00:00:00
abstract::Metabolic syndrome (MetS) is a major public health concern. Efficient screening requires criteria that are economical, easily accessible, and applicable for all populations. We aimed to compare the discriminating ability of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) for the diagn...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008192
更新日期:2017-09-01 00:00:00
abstract::Central nervous system (CNS) nocardiosis is a rare disease entity caused by the filamentous bacteria Nocardia species. We present a case series of 5 patients from our hospital and a review of the cases of CNS nocardiosis reported in the literature from January 2000 to December 2011. Our results indicate that CNS nocar...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000000012
更新日期:2014-01-01 00:00:00
abstract::Taking into consideration the progress in cancer treatment, an increase in the number of adult survivors of childhood cancer is expected. These survivors will have received treatment that predisposes them to late morbidity and increased risk of early mortality. The aim of this single-center retrospective cohort study ...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000014921
更新日期:2019-03-01 00:00:00
abstract:RATIONALE:Multiple primary central nervous system lymphoma (MPCNSL) is a rare disease with differential diagnosis and treatment. As the underlying pathogenesis is not yet clarified, the early-stage clinical manifestations are occult and atypical. Also, the imaging manifestations are not specific, which is challenging f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016841
更新日期:2019-08-01 00:00:00
abstract::A significant rise in the prevalence of type 2 diabetes mellitus (T2DM) in the Middle-east and North Africa (MENA) region has seen over the last few decades. The present observational study aimed to evaluate and compare the risk of developing T2DM in the cities of Riyadh and Amman using the Arab Diabetes Risk Assessme...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012689
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Long-term use of aspirin for primary prevention of cancer remains inconclusive, and variation in the effects of aspirin use on cancer outcomes by cancer site, aspirin dose, follow-up duration, or different populations has never been systematically evaluated. METHODS:Seven electronic databases (PubMed, EMBAS...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017382
更新日期:2019-09-01 00:00:00
abstract:RATIONALE:Report a case of bilateral multiple retinal hamartomas (RAHs) in a patient with tuberous sclerosis complex (TSC) and introduced a new method (subthreshold micropulse laser photocoagulation) for the treatment of RAHs. PATIENT CONCERNS:A 20-year-old man with TSC complained of decreased vision and metamorphosia...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013265
更新日期:2018-12-01 00:00:00