New breast cancer prognostic factors identified by computer-aided image analysis of HE stained histopathology images.

abstract：:Global lake systems have undergone rapid degradation over the past century. Scientists and managers are struggling to manage the highly degraded lake systems to cope with escalating anthropogenic pressures. Improved knowledge of how lakes and social systems co-evolved up to the present is vital for understanding, mode...

journal_title：Scientific reports

authors： Zhang K,Yang X,Kattel G,Lin Q,Shen J

更新日期：2018-11-21 00:00:00

abstract：:Most studies on ungulate reproduction have focused on the covariates of male reproductive success, while there is much less information on female tactics of mate choice. The aim of this work is to fill this gap and to assess condition-dependent variations in female tactics in a lekking fallow deer (Dama dama) populati...

journal_title：Scientific reports

authors： Imperio S,Lombardi S,De Marinis A,Ronchi F,Santini G,Focardi S

更新日期：2020-02-27 00:00:00

abstract：:Spinal cord injury (SCI) leads to wide-spread neurodegeneration across the neuroaxis. We explored trajectories of surface morphology, demyelination and iron concentration within the basal ganglia-thalamic circuit over 2 years post-SCI. This allowed us to explore the predictive value of neuroimaging biomarkers and dete...

journal_title：Scientific reports

authors： Huber E,Patel R,Hupp M,Weiskopf N,Chakravarty MM,Freund P

更新日期：2020-08-24 00:00:00

abstract：:The global increase in Diabetes Mellitus (DM) has led to an increase in DM-Chronic Kidney Disease (DM-CKD). In this cross-sectional observational study we aimed to define phenotypes for patients with DM-CKD that in future may be used to individualise treatment We report 4 DM-CKD phenotypes in 220 patients recruited fr...

journal_title：Scientific reports

authors： Montero RM,Herath A,Qureshi A,Esfandiari E,Pusey CD,Frankel AH,Tam FWK

更新日期：2018-01-08 00:00:00

abstract：:The dispersion of organic N-benzyl-2-methyl-4-nitroaniline (BNA) in nematic liquid crystals (LCs) is studied. BNA doping decreases the threshold voltage of cell because of the reduced splay elastic constant and increased dielectric anisotropy of the LC mixture. When operated in the high voltage difference condition, t...

journal_title：Scientific reports

authors： Selvaraj P,Subramani K,Srinivasan B,Hsu CJ,Huang CY

更新日期：2020-08-31 00:00:00

abstract：:cAMP responsive element binding protein 3-like 3 (CREB3L3), a transcription factor expressed in the liver and small intestine, governs fasting-response energy homeostasis. Tissue-specific CREB3L3 knockout mice have not been generated till date. To our knowledge, this is the first study using the one-step CRISPR/Cas9 s...

journal_title：Scientific reports

authors： Nakagawa Y,Oikawa F,Mizuno S,Ohno H,Yagishita Y,Satoh A,Osaki Y,Takei K,Kikuchi T,Han SI,Matsuzaka T,Iwasaki H,Kobayashi K,Yatoh S,Yahagi N,Isaka M,Suzuki H,Sone H,Takahashi S,Yamada N,Shimano H

更新日期：2016-06-13 00:00:00

abstract：:A major task of episodic memory is to create unique, distinguishable representations of highly overlapping perceptual inputs. Several studies on this basic function have shown that it is based on the intact functioning of certain subregions of the hippocampus and is among the most sensitive behavioral indicators of mi...

journal_title：Scientific reports

authors： Pajkossy P,Szőllősi Á,Racsmány M

更新日期：2020-10-02 00:00:00

abstract：:Coral reefs face a crisis due to local and global anthropogenic stressors. A large proportion of the ~50% coral loss on the Great Barrier Reef has been attributed to outbreaks of the crown-of-thorns-seastar (COTS). A widely assumed cause of primary COTS outbreaks is increased larval survivorship due to higher food ava...

journal_title：Scientific reports

authors： Uthicke S,Logan M,Liddy M,Francis D,Hardy N,Lamare M

更新日期：2015-02-12 00:00:00

abstract：:Cardiorenal syndrome is defined by primary heart failure conditions influencing or leading to renal injury or dysfunction. Dilated cardiomyopathy (DCM) is a major co-existing form of heart failure (HF) with renal diseases. Myocardin (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased ...

journal_title：Scientific reports

authors： Mittal A,Rana S,Sharma R,Kumar A,Prasad R,Raut SK,Sarkar S,Saikia UN,Bahl A,Dhandapany PS,Khullar M

更新日期：2019-04-10 00:00:00

abstract：:Soil microbial responses to fire are likely to change over the course of forest recovery. Investigations on long-term changes in bacterial dynamics following fire are rare. We characterized the soil bacterial communities across three different times post fire in a 2 to 152-year fire chronosequence by Illumina MiSeq se...

journal_title：Scientific reports

authors： Sun H,Santalahti M,Pumpanen J,Köster K,Berninger F,Raffaello T,Asiegbu FO,Heinonsalo J

更新日期：2016-08-30 00:00:00

abstract：:Testosterone is involved in male sexual, parental and aggressive behaviors through the androgen receptor (AR) and estrogen receptor (ER) α expressed in the brain. Although several studies have demonstrated that ERα and AR in the medial preoptic area (MPOA) are required for exhibiting sexual and aggressive behaviors of...

journal_title：Scientific reports

authors： Tsuneoka Y,Yoshida S,Takase K,Oda S,Kuroda M,Funato H

更新日期：2017-08-29 00:00:00

abstract：:Protein-peptide interactions play an important role in major cellular processes, and are associated with several human diseases. To understand and potentially regulate these cellular function and diseases it is important to know the molecular details of the interactions. However, because of peptide flexibility and the...

journal_title：Scientific reports

authors： Johansson-Åkhe I,Mirabello C,Wallner B

更新日期：2019-03-12 00:00:00

abstract：:In comparison to genome-wide association studies (GWAS), there has been poor replication of gene expression studies in chronic obstructive pulmonary disease (COPD). We performed microarray gene expression profiling on a large sample of resected lung tissues from subjects with severe COPD. Comparing 111 COPD cases and ...

journal_title：Scientific reports

authors： Morrow JD,Zhou X,Lao T,Jiang Z,DeMeo DL,Cho MH,Qiu W,Cloonan S,Pinto-Plata V,Celli B,Marchetti N,Criner GJ,Bueno R,Washko GR,Glass K,Quackenbush J,Choi AM,Silverman EK,Hersh CP

更新日期：2017-03-13 00:00:00

abstract：:Effective promotion of air filtration applications proposed for fibers requires their real nanoscale diameter, optimized pore structure, and high service strength; however, creating such filter medium has proved to be a tremendous challenge. This study first establishes a strategy to design and fabricate novel poly(m-...

journal_title：Scientific reports

authors： Zhang S,Liu H,Yin X,Li Z,Yu J,Ding B

更新日期：2017-01-11 00:00:00

abstract：:Forest cutting is a major anthropogenic disturbance that affects forest carbon (C) storage and fluxes. Yet its characteristics and impacts on C cycling are poorly understood over large areas. Using recent annualized forest inventory data, we estimated cutting-related loss of live biomass in the eastern United States w...

journal_title：Scientific reports

authors： Zhou D,Liu S,Oeding J,Zhao S

更新日期：2013-12-19 00:00:00

abstract：:Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and is now being investigated as a medium for local, prolonged drug delivery. Effective local delivery of antibacterial substances is important perioperatively in patients with implanted medical devices or postoperatively for de...

journal_title：Scientific reports

authors： Rubalskii E,Ruemke S,Salmoukas C,Aleshkin A,Bochkareva S,Modin E,Mashaqi B,Boyle EC,Boethig D,Rubalsky M,Zulkarneev E,Kuehn C,Haverich A

更新日期：2019-02-14 00:00:00

abstract：:One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report he...

journal_title：Scientific reports

authors： Schroeder K,Chiggiato J,Bryden HL,Borghini M,Ben Ismail S

更新日期：2016-03-11 00:00:00

abstract：:In this report, spherical silver nanoparticle (AgNP-sp) and rod-shaped silver nanoparticle (AgNR) were prepared by chemical reduction method and their antibacterial activity against various Gram-positive and Gram-negative bacteria had been evaluated for their efficiency. Minimal inhibitory concentration (MIC) tests we...

journal_title：Scientific reports

authors： Acharya D,Singha KM,Pandey P,Mohanta B,Rajkumari J,Singha LP

更新日期：2018-01-09 00:00:00

abstract：:Profiling immune repertoires by high throughput sequencing enhances our understanding of immune system complexity and immune-related diseases in humans. Previously, cloning and Sanger sequencing identified limited numbers of T cell receptor (TCR) nucleotide sequences in rhesus monkeys, thus their full immune repertoir...

journal_title：Scientific reports

authors： Li Z,Liu G,Tong Y,Zhang M,Xu Y,Qin L,Wang Z,Chen X,He J

更新日期：2015-05-11 00:00:00

abstract：:The medicinal leech has established a long-term mutualistic association with Aeromonas veronii, a versatile bacterium which can also display free-living waterborne and fish- or human-pathogenic lifestyles. Here, we investigated the role of antibiotics in the dynamics of interaction between the leech and its gut symbio...

journal_title：Scientific reports

authors： Tasiemski A,Massol F,Cuvillier-Hot V,Boidin-Wichlacz C,Roger E,Rodet F,Fournier I,Thomas F,Salzet M

更新日期：2015-12-04 00:00:00

abstract：:The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus s...

journal_title：Scientific reports

authors： Yan J,Dong J,Wu J,Zhu R,Wang Z,Wang B,Wang L,Wang Z,Zhang H,Wu H,Yu B,Kong W,Yu X

更新日期：2016-03-03 00:00:00

abstract：:Neurogenesis of hippocampal granule cells (GCs) persists throughout mammalian life and is important for learning and memory. How newborn GCs differentiate and mature into an existing circuit during this time period is not yet fully understood. We established a method to visualize postnatally generated GCs in organotyp...

journal_title：Scientific reports

authors： Radic T,Jungenitz T,Singer M,Beining M,Cuntz H,Vlachos A,Deller T,Schwarzacher SW

更新日期：2017-03-03 00:00:00

abstract：:Human CD4+ T cells play an important role in the immune response to Mycobacterium tuberculosis (MTB). However, little is known about the spectratyping characteristics of the CD4+ T-cell receptor (TCR) α- and β-chains CDR3 region in tuberculosis (TB) patients. We sorted MTB peptide E7-bound CD4+ T cells by using E7/HLA...

journal_title：Scientific reports

authors： Gan Y,Wang C,Fang Y,Yao Y,Tu X,Wang J,Huang X,Tan Y,Chen T,Zhang K,Shen Y,Zhou L,Liu J,Lai X

更新日期：2018-07-02 00:00:00

abstract：:We propose an ultrathin metallic structure to produce frequency-selective spoof surface plasmon polaritons (SPPs) in the microwave and terahertz frequencies. Designed on a thin dielectric substrate, the ultrathin metallic structure is composed of two oppositely oriented single-side corrugated strips, which are coupled...

journal_title：Scientific reports

authors： Yin JY,Ren J,Zhang HC,Pan BC,Cui TJ

更新日期：2015-02-02 00:00:00

abstract：:The first-ever study of nickel selenide materials as efficient anode materials for Na-ion rechargeable batteries is conducted using the electrospinning process. NiSe2-reduced graphene oxide (rGO)-C composite nanofibers are successfully prepared via electrospinning and a subsequent selenization process. The electrospun...

journal_title：Scientific reports

authors： Cho JS,Lee SY,Kang YC

更新日期：2016-03-21 00:00:00

abstract：:Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with an implanted electrode holds promise in the treatment of these conditions. However, there are several limitations to its application, including poor bio-compatibility an...

journal_title：Scientific reports

authors： Skach J,Conway C,Barrett L,Ye H

更新日期：2020-10-22 00:00:00

abstract：:Toll-like receptors (TLRs) play a key role in innate and adaptive immunity, protecting the host from viral pathogens. We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults. Blood samples were taken from 612 patients with confirmed...

journal_title：Scientific reports

authors： Zhu J,Zhang T,Cao L,Li A,Zheng K,Zhang N,Su B,Chen Z,Chen N,Wu H,He Q

更新日期：2017-09-29 00:00:00

abstract：:Stress-induced alteration in endothelial cells (ECs) integrity precedes the development of atherosclerosis. Previous studies showed that the soluble recombinant thrombomodulin (rTM) not only increases ECs proliferation but also exerts anti-apoptotic activity in ECs. However, the functional significance of soluble rTM ...

journal_title：Scientific reports

authors： Chen PS,Wang KC,Chao TH,Chung HC,Tseng SY,Luo CY,Shi GY,Wu HL,Li YH

更新日期：2017-06-12 00:00:00

abstract：:Amyloid formation is associated with various pathophysiological conditions like Alzheimer's and Parkinson's diseases as well as many useful functions. The hallmark of amyloid assemblies is a conformational transition of the constituent proteins into a β - sheet rich filament. Accounting for this conformational transit...

journal_title：Scientific reports

authors： Ranganathan S,Ghosh D,Maji SK,Padinhateeri R

更新日期：2016-02-17 00:00:00

abstract：:The uncertainty relation is a fundamental limit in quantum mechanics and is of great importance to quantum information processing as it relates to quantum precision measurement. Due to interactions with the surrounding environment, a quantum system will unavoidably suffer from decoherence. Here, we investigate the dyn...

journal_title：Scientific reports

authors： Wang D,Huang AJ,Hoehn RD,Ming F,Sun WY,Shi JD,Ye L,Kais S

更新日期：2017-04-21 00:00:00