Abstract:
:The effectiveness of vaccinating males against the human papillomavirus (HPV) remains a controversial subject. Many existing studies conclude that increasing female coverage is more effective than diverting resources into male vaccination. Recently, several empirical studies on HPV immunization have been published, providing evidence of the fact that marginal vaccination costs increase with coverage. In this study, we use a stochastic agent-based modeling framework to revisit the male vaccination debate in light of these new findings. Within this framework, we assess the impact of coverage-dependent marginal costs of vaccine distribution on optimal immunization strategies against HPV. Focusing on the two scenarios of ongoing and new vaccination programs, we analyze different resource allocation policies and their effects on overall disease burden. Our results suggest that if the costs associated with vaccinating males are relatively close to those associated with vaccinating females, then coverage-dependent, increasing marginal costs may favor vaccination strategies that entail immunization of both genders. In particular, this study emphasizes the necessity for further empirical research on the nature of coverage-dependent vaccination costs.
journal_name
Epidemicsjournal_title
Epidemicsauthors
Ryser MD,McGoff K,Herzog DP,Sivakoff DJ,Myers ERdoi
10.1016/j.epidem.2015.01.003subject
Has Abstractpub_date
2015-06-01 00:00:00pages
32-47eissn
1755-4365issn
1878-0067pii
S1755-4365(15)00005-5journal_volume
11pub_type
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