Abstract：
BACKGROUND:From 2007 to 2009, the Netherlands experienced a major Q fever epidemic. Long-term serological follow-up of acute Q fever patients enabled the investigation of longitudinal antibody responses and estimating the onset of the seroresponse in individual patients. METHODS:All available IgG and IgM phase I and II antibody measurements determined by immunofluorescence assay at month 3, 6, 12, and 48 from 2321 acute Q fever patients were retrospectively analyzed. Characteristic features of the antibody response were calculated. To model the seroresponse onset, serological data from patients diagnosed with a positive C. burnetii PCR test (n=364), and therefore with a known time of infection, were used as reference. RESULTS:In 9083 IgG samples and 3260 IgM samples large heterogeneity in shape and magnitude of antibody responses was observed. Phase II reached higher levels than phase I, and IgG antibodies were more persistent than IgM. The estimated seroresponse latency allowed for determining the time since start of the seroresponse from the concentrations of the different antibodies against C. burnetii. CONCLUSIONS:The extraordinary large serological dataset provides new insight into the kinetics of the immunoglobulins against C. burnetii antigens. This knowledge is useful for seroprevalence studies and helps to better understand infection dynamics.
journal_name
Epidemicsjournal_title
Epidemicsauthors
Wielders CC,Teunis PF,Hermans MH,van der Hoek W,Schneeberger PMdoi
10.1016/j.epidem.2015.07.001subject
Has Abstractpub_date
2015-12-01 00:00:00pages
37-43eissn
1755-4365issn
1878-0067pii
S1755-4365(15)00065-1journal_volume
13pub_type
杂志文章相关文献
Epidemics文献大全abstract：:The existence of primary pneumonic plague outbreaks raises concerns over the use of the causative bacteria as an aerosol-based bioweapon. We employed an individual-based model, parameterised using published personal contact information, to assess the severity of a deliberate release in a discrete community, under the ...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2011.03.001
更新日期：2011-06-01 00:00:00
abstract：:Emerging evidence suggests that HIV incidence rates in Brazil, particularly among men, may be rising. Here we use Brazil's integrated health systems data to develop a mathematical model, reproducing the complex surveillance systems and providing estimates of HIV incidence, number of people living with HIV (PLHIV), rep...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2019.02.002
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Pathogenic bacteria are often asymptomatically carried in the nasopharynx. Bacterial carriage can be reduced by vaccination and has been used as an alternative endpoint to clinical disease in randomised controlled trials (RCTs). Vaccine efficacy (VE) is usually calculated as 1 minus a measure of effect. Esti...
journal_title：Epidemics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.epidem.2014.08.003
更新日期：2014-12-01 00:00:00
abstract：:Dengue dynamics are shaped by the complex interplay between several factors, including vector seasonality, interaction between four virus serotypes, and inapparent infections. However, paucity or quality of data do not allow for all of these to be taken into account in mathematical models. In order to explore separate...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2018.08.004
更新日期：2019-03-01 00:00:00
abstract：:Previous exposure to influenza viruses confers cross-immunity against future infections with related strains. However, this is not always accounted for explicitly in mathematical models used for forecasting during influenza outbreaks. We show that, if an influenza outbreak is due to a strain that is similar to one tha...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2020.100432
更新日期：2020-12-17 00:00:00
abstract：:Dengue is one of the most important and wide-spread viral infections affecting human populations. The last few decades have seen a dramatic increase in the global burden of dengue, with the virus now being endemic or near-endemic in over 100 countries world-wide. A recombinant tetravalent vaccine candidate (CYD-TDV) h...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2016.05.003
更新日期：2016-09-01 00:00:00
abstract：:Studying the emergence of novel infectious agents involves many processes spanning host species, spatial scales, and scientific disciplines. Mathematical models play an essential role in combining insights from these investigations and drawing robust inferences from field and experimental data. We describe nine challe...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2014.09.002
更新日期：2015-03-01 00:00:00
abstract：:Disease models which take explicit account of heterogeneities in the risk of infection offer significant advantages over models in which the risk of infection is assumed to be uniform across all hosts. However, estimating the incidence rate (force of infection) in the different at-risk (exposure) groups is no easy mat...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2013.04.002
更新日期：2013-06-01 00:00:00
abstract：:Syndromic and virological data are routinely collected by many countries and are often the only information available in real time. The analysis of surveillance data poses many statistical challenges that have not yet been addressed. For instance, the fraction of cases that seek healthcare and are thus detected is oft...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2011.11.001
更新日期：2012-03-01 00:00:00
abstract：:A stochastic, spatial, discrete-time, SEIR model of avian influenza epidemics among poultry farms in Pennsylvania is formulated. Using three different spatial scales wherein all the birds within a single farm, ZIP code, or county are clustered into a single point, we obtain three different views of the epidemics. For ...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2011.02.003
更新日期：2011-06-01 00:00:00
abstract：:Computer models have proven to be useful tools in studying epidemic disease in human populations. Such models are being used by a broader base of researchers, and it has become more important to ensure that descriptions of model construction and data analyses are clear and communicate important features of model struc...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2016.12.001
更新日期：2017-06-01 00:00:00
abstract：:Mathematical models of disease transmission are used to improve our understanding of patterns of infection and to identify factors influencing them. During recent public and animal health crises, such as pandemic influenza, Ebola, Zika, foot-and-mouth disease, models have made important contributions in addressing pol...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2017.12.003
更新日期：2018-06-01 00:00:00
abstract：:For infections that are typically asymptomatic, targeted surveillance systems (whereby individuals at increased risk are tested more frequently) will detect infections earlier on average than systems with random testing or in systems where all individuals are tested at the same intervals. However, estimating temporal ...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2012.09.003
更新日期：2012-12-01 00:00:00
abstract：:The sociological and biological factors which gave rise to the three pandemic waves of Spanish influenza in England during 1918-19 are still poorly understood. Symptom reporting data available for a limited set of locations in England indicates that reinfection in multiple waves occurred, suggesting a role for loss of...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2014.07.004
更新日期：2014-09-01 00:00:00
abstract：:Seasonal influenza is a worldwide public health concern. Forecasting its dynamics can improve the management of public health regulations, resources and infrastructure, and eventually reduce mortality and the costs induced by influenza-related absenteism. In Belgium, a network of Sentinel General Practitioners (SGPs) ...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2019.04.001
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Brazil has the second highest annual number of new leprosy cases. The aim of this study is to formally compare predictions of future new case detection rate (NCDR) trends and the annual probability of NCDR falling below 10/100,000 of four different modelling approaches in four states of Brazil: Rio Grande do...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2017.01.005
更新日期：2017-03-01 00:00:00
abstract：:Many diseases exhibit subcritical transmission (i.e. 0 journal_title：Epidemics pub_type： 杂志文章 doi：10.1016/j.epidem.2013.05.002 更新日期：2013-09-01 00:00:00
abstract：:Disease is a major constraint on animal production and welfare in agriculture and aquaculture. Movement of animals between farms is one of the most significant routes of disease transmission and is particularly hard to control for pathogens with subclinical infection. Renibacterium salmoninarum causes bacterial kidney...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2011.10.002
更新日期：2011-09-01 00:00:00
abstract：:The effectiveness of vaccinating males against the human papillomavirus (HPV) remains a controversial subject. Many existing studies conclude that increasing female coverage is more effective than diverting resources into male vaccination. Recently, several empirical studies on HPV immunization have been published, pr...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2015.01.003
更新日期：2015-06-01 00:00:00
abstract：:To reach the WHO goal of hepatitis C elimination, it is essential to identify the number of people unaware of their hepatitis C virus (HCV) infection and to investigate the effect of interventions on the disease transmission dynamics. In many high-income countries, one of the primary routes of HCV transmission is via ...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2019.100378
更新日期：2019-12-11 00:00:00
abstract：:Producing timely, well-informed and reliable forecasts for an ongoing epidemic of an emerging infectious disease is a huge challenge. Epidemiologists and policy makers have to deal with poor data quality, limited understanding of the disease dynamics, rapidly changing social environment and the uncertainty on effects ...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2017.02.010
更新日期：2018-03-01 00:00:00
abstract：:Mathematical modeling of disease transmission has provided quantitative predictions for health policy, facilitating the evaluation of epidemiological outcomes and the cost-effectiveness of interventions. However, typical sensitivity analyses of deterministic dynamic infectious disease models focus on model architectur...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2013.11.002
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVES:There has been a growing concern over Zika virus (ZIKV) infection, particularly since a probable link between ZIKV infection during pregnancy and microcephaly in the baby was identified. The present study aimed to estimate a theoretical risk of microcephaly during pregnancy with ZIKV infection in Northeaster...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2016.03.001
更新日期：2016-06-01 00:00:00
abstract：:Many pathogens of conservation concern circulate endemically within natural wildlife reservoir hosts and it is imperative to understand the individual and ecological drivers of natural transmission dynamics, if any threat to a related endangered species is to be assessed. Our study highlights the key drivers of infect...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2019.100352
更新日期：2019-09-01 00:00:00
abstract：:Influenza infection natural history is often described as a progression through four successive stages: Susceptible-Exposed/Latent-Infectious-Removed (SEIR). The duration of each stage determines the average generation time, the time between infection of a case and infection of his/her infector. Recently, several auth...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2012.06.001
更新日期：2012-08-01 00:00:00
abstract：:Healthcare-associated infections cause significant patient morbidity and mortality, and contribute to growing healthcare costs, whose effects may be felt most strongly in developing countries. Active surveillance systems, hospital staff compliance, including hand hygiene, and a rational use of antimicrobials are among...
journal_title：Epidemics
pub_type： 杂志文章,多中心研究
doi：10.1016/j.epidem.2018.11.001
更新日期：2019-03-01 00:00:00
abstract：:Coexistence of multiple tick-borne pathogens or strains is common in natural hosts and can be facilitated by resource partitioning of the host species, within-host localization, or by different transmission pathways. Most vector-borne pathogens are transmitted horizontally via systemic host infection, but transmission...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2016.12.002
更新日期：2017-06-01 00:00:00
abstract：:Although empirical studies show that protection against influenza infection in humans is closely related to antibody titres, influenza epidemics are often described under the assumption that individuals are either susceptible or not. Here we develop a model in which antibody titre classes are enumerated explicitly and...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2017.03.003
更新日期：2017-09-01 00:00:00
abstract：:Detailed results on the dynamics of cowpox virus infection in four natural populations of the field vole, Microtus agrestis, are presented. Populations were sampled every 4 weeks (8 weeks in mid-winter) for 6 years. The purpose was to examine the relationships between overall or susceptible host abundance (N, S) and b...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2008.10.001
更新日期：2009-03-01 00:00:00
abstract：:Due to the COVID-19 pandemic, many countries have implemented a complete lockdown of their population that may not be sustainable for long. To identify the best strategy to replace this full lockdown, sophisticated models that rely on mobility data have been developed. In this study, using the example of France as a c...
journal_title：Epidemics
pub_type： 杂志文章
doi：10.1016/j.epidem.2020.100424
更新日期：2020-12-01 00:00:00
