Abstract:
AIM:To investigate whether ATP-sensitive potassium (K(ATP)) channels modulate the tocolytic effect of β2-adrenergic receptor (β2-AR) agonists (ritodrine and salmeterol) in early-pregnant (day 6) and late-pregnant (day 22) rat uterus in vitro, in order to examine the relation between the K(ATP) channel sulphonylurea-binding regulatory subunit (SUR) expression and pharmacological reactivity of β2-AR agonists. METHODS:The tocolytic effects of ritodrine and salmeterol (10(-10)-10(-5) M) on spontaneous rhythmic contractions were investigated cumulatively, alone, or in the presence of the K(ATP) channel blocker glibenclamide (10(-6) M) and the K(ATP) channel opener pinacidil (10(-9)-10(-7) M) after 5-min preincubation. RESULTS:β2-AR agonist induced myometrial relaxation was inhibited by glibenclamide and enhanced by pinacidil on day 6, when SUR1 expression levels were high. Neither glibenclamide nor pinacidil mediated tocolytic effect was measured on day 22. CONCLUSION:Low expression of the K(ATP) channels at the end of gestation may facilitate enhanced excitability and contractility in the rat myometrium. The combination of a betamimetic and a K(ATP) channel opener will therefore not be of therapeutic relevance in the treatment of preterm delivery.
journal_name
Croat Med Jjournal_title
Croatian medical journalauthors
Lovasz N,Koncz A,Domokos D,Gaspar R,Falkay Gdoi
10.3325/cmj.2015.56.114subject
Has Abstractpub_date
2015-04-01 00:00:00pages
114-8issue
2eissn
0353-9504issn
1332-8166journal_volume
56pub_type
杂志文章abstract:AIM:To examine plasma concentration of IgA, IgM, IgG classes, and IgG1, IgG2, IgG3, and IgG4 subclasses in children with autism. METHODS:Infantile autism was diagnosed by the Diagnostic and Statistical Manual for Mental Disorders (DSM)-IV and the International Classification of Diseases (ICD)-10 criteria. Plasma sampl...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract:AIM:To investigate the influence of 1991-1995 war on the prevalence, duration, and practice of breast-feeding Croatian children up to 5 years of age. METHOD:In 1996, interviews were conducted in households with children up to 2 years of age (757 children) and 2-5 years of age (1,180 children). Data for war-free areas,...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:AIM:To assess the incidence and timing of cardiac rupture following streptokinase (SK) administration in acute myocardial infarction (AMI). METHODS:We analyzed retrospectively the clinical sheets of AMI patients treated at the Coronary Care Unit in University Hospital Split, Croatia, between January 1, 1996, and Decem...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:AIM:To analyze the incidence, transvaginal detection age, sonographic appearance, clinical course, and outcomes of pregnancy in cases with abnormal fetal brain structure and/or circulation, and to evaluate the clinical significance of sonographic abnormalities. METHODS:Serial observation of the fetal brain and intracr...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::A radical primary health care-oriented reform of the medical services in Albania is now under way, calling for adequate revision in medical education. The reform has started in 1994. In January 1997, the Department of Family Medicine at the Faculty of Medicine, University of Tirana, was established for the development...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract:AIM:To analyze the haplotype of the Ezhava population of Kerala, south India, using 8 short tandem repeat (STR) loci on the Y chromosome and trace the paternal genetic lineage of the population. METHODS:Whole blood samples (n=104) were collected from unrelated healthy men of the Ezhava population over a period of one ...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2011.52.344
更新日期:2011-06-01 00:00:00
abstract::This article brings an overview of the influence of molecular medicine on pathophysiology, medical practice, and medical education. Various aspects of the growing impact of molecular medicine on clinical practice are discussed: diagnostic and predictive testing, gene and targeted therapy, and pharmacogenomics. Insuffi...
journal_title:Croatian medical journal
pub_type: 社论
doi:
更新日期:2003-08-01 00:00:00
abstract:AIM:To evaluate the primary health care information system from the general practitioner's (GP) point of view. METHODS:Sixty-seven Croatian GPs were distributed a questionnaire about characteristics of the GP's office, overall impression of the application, handling of daily routine information, more sophisticated inf...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2012.53.60
更新日期:2012-02-15 00:00:00
abstract:AIM:To examine how 5-factor personality traits (extraversion, agreeableness, conscientiousness, neuroticism, and openness) and 3 higher-order health-related personality constructs (negative experience, optimistic control, and passivity) are related to self-reports of subjective health outcomes (positive and negative mo...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2009.50.394
更新日期:2009-08-01 00:00:00
abstract:AIM:To assess the influence of depression on patients' satisfaction with lumbar discectomy performed by two different surgical techniques. METHODS:A prospective matched-cohort analysis of classical lumbar discectomy following static imaging (n = 45) and microlumbar "key-hole" discectomy after dynamic CT/myelography (n...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::A continuous rise in life expectancy has led to an increase in the number of senior citizens, now amounting to a fifth of the global population, and to a dramatic increase in the prevalence of diseases of the elderly. This review discusses the threat of dementia, a disease that imposes enormous financial burden on hea...
journal_title:Croatian medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2020-04-30 00:00:00
abstract:AIM:To evaluate the existing evidence on relative efficacy and tolerability of topical mono-compound intraocular pressure (IOP)-lowering drugs in treatment of primary open angle glaucoma (POAG) and ocular hypertension (OHT). METHODS:In this systematic review of systematic reviews/meta-analyses of randomized controlled...
journal_title:Croatian medical journal
pub_type: 杂志文章,评审
doi:10.3325/cmj.2014.55.468
更新日期:2014-10-01 00:00:00
abstract:AIM:To examine the feasibility of using peer review for the quality control of online materials. METHODS:We analyzed the inter-rater agreement on the quality of epidemiological lectures online, based on the Global Health Network Supercourse lecture library. We examined the agreement among reviewers by looking at kappa...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::The calculation of the heart axis in the frontal plane can be performed with the combination of any two leads. The use of combination of bipolar (I, II, III) and unipolar leads (aVR, aVL and aVF) can produce wrong results. Calculation of the electrical axis from leads I and aVF without correction (sometimes used in EC...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:AIM:To study the association between genetic variants in myocilin and collagen type I alpha 1 genes and high myopia in an isolated island population. METHODS:A total of 944 examinees from the genetic epidemiology study conducted on the island of Korcula, Croatia, were included in the study. We selected 2 short nucleot...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2009.50.17
更新日期:2009-02-01 00:00:00
abstract:AIM:Analysis of countertransference problems in the treatment of a heterogeneous group of war veterans. METHOD:The method used in this work was psychodynamic clinical observation and analysis of countertransference phenomena in group therapy. RESULTS:In the beginning of our work, we faced with a regressive group, whi...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract:AIM:To retrospectively analyze the rate of multi-type abuse in childhood and the effects of childhood abuse and type of coping strategies on the psychological adaptation of young adults in a sample form the student population of the University of Mostar. METHODS:The study was conducted on a convenience sample of 233 s...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2010.51.406
更新日期:2010-10-01 00:00:00
abstract:AIM:To report on our experience with a voice-directed robotic arm for scope management in different procedures for "solo-surgery" and in complex laparoscopic operations. METHODS:A chip card with orders for the robotic arm is individually manufactured for every user. A surgeon gives order through a microphone and the o...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::Polish physicians-philosophers tried to find a compromise between medicine as a science and medicine as a healing art. They stated that clinical practice should be transformed into science, bearing in mind that there would be no medicine without the existence of the sick. A perfect physician is a good and wise person ...
journal_title:Croatian medical journal
pub_type: 历史文章,杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:AIM:To compare the quality of the 2008 cancer mortality data of the Istanbul Directorate of Cemeteries (IDC) with the 2008 data of International Agency for Research on Cancer (IARC) and Turkish Statistical Institute (TUIK), and discuss the suitability of using this databank for estimations of cancer mortality in the fu...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2012.53.480
更新日期:2012-10-01 00:00:00
abstract::The generally accepted structure of a scientific paper is four sections, an introduction, a methods section, the results, and a discussion. This so-called IMRaD format is, with a few small variations, found in most research articles in biomedical journals. However, as a guide for someone writing up research data for t...
journal_title:Croatian medical journal
pub_type: 社论
doi:
更新日期:2002-06-01 00:00:00
abstract::Throughout the Middle Ages a unique Croatian Glagolitic script co-existed with Latin and western Cyrillic scripts, thus creating an open, large, and tolerant cultural environment. Many works common to European cultural heritage were translated into Croatian (Church Slavonic) language and preserved in the Glagolitic sc...
journal_title:Croatian medical journal
pub_type: 历史文章,杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::The aim of this article is to offer a concise interpretation of the scientific data about the topic of Croatian genetic heritage that was obtained over the past 10 years. We made a short overview of previously published articles by our and other groups, based mostly on Y-chromosome results. The data demonstrate that C...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2011.52.225
更新日期:2011-06-01 00:00:00
abstract:AIM:To determine the prevalence of bronchial asthma among Saudi Arabian schoolboys living in Al-Khobar city. METHODS:Parents of 1,482 randomly selected boys in preparatory and elementary schools included in this cross-sectional study filled out a questionnaire on asthma signs in their sons. Number of Questionnaire-Dia...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:AIM:To compare the prevalence and characteristics of bullying between two towns in Bosnia and Herzegovina-Stolac, which was exposed to firearm conflict during the 1992-1995 war in Bosnia and Herzegovina, and Posusje, which was outside of the active combat zone. METHODS:In this cross-sectional study, we included 484 pr...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2008.4.528
更新日期:2008-08-01 00:00:00
abstract::Photolysis or "uncaging" of caged compounds represents a significant tool in cell biology and chemistry. It provides a means for quantitative control of compound delivery with temporal and spatial resolution while observing their consequences for cellular signaling. We discuss the use of ultraviolet-transmitting optic...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::This article explores the merits of foregrounding the dichotomy of politicization vs de-politicization for our understanding of bio-objects in order to study their production, circulation, and governance in European societies. By asking how bio-objects are configured in science, policy, public, and media discourses an...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2013.54.206
更新日期:2013-04-01 00:00:00
abstract:AIM:To evaluate the efficacy and toxicity of preoperative chemoradiotherapy with capecitabine in locally advanced rectal cancer. METHODS:Between June 2004 and January 2005, 57 patients with operable, clinical stage II-III adenocarcinoma of the rectum entered the prospective phase II study. Radiation dose was 45 Gy (25...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract:AIM:To determine whether and in what concentrations the underground waters, stream waters, spring water, and tap water from the Zagreb area contain phthalates -- compounds used as plastic softeners, which have recently been ascribed carcinogenic, mutagenic, and teratogenic effects. METHOD:The presence of dimethyl phth...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract:AIM:To compare morbidity and mortality of patients with severe intra-abdominal infections after two types of surgical treatment, on-demand ("wait and see") relaparotomy and modified planned relaparotomy. METHODS:We prospectively analyzed the outcomes of 65 patients with severe peritonitis surgically treated in two Cro...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00