Abstract:
:This article brings an overview of the influence of molecular medicine on pathophysiology, medical practice, and medical education. Various aspects of the growing impact of molecular medicine on clinical practice are discussed: diagnostic and predictive testing, gene and targeted therapy, and pharmacogenomics. Insufficient data from appropriate clinical studies and evidence-based medicine presently limit the applications of molecular medicine in clinical practice. Incorporation of conceptual and clinical aspects of molecular medicine in undergraduate and postgraduate curricula and a continuing education of medical professionals is an urgent imperative for the demands of medical care quality to be met in near future. The emphasis should be put on bedside-orientated molecular medicine. The prerequisite is translational research aimed to translate basic information into the improvement of healthcare of individual patients and the population as a whole.
journal_name
Croat Med Jjournal_title
Croatian medical journalauthors
Gamulin Skeywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
374-85issue
4eissn
0353-9504issn
1332-8166journal_volume
44pub_type
社论abstract:AIM:To evaluate psychosomatic complaints and depressive symptoms among civilians, refugees, and soldiers in the war and post-war period in Croatia. METHOD:The design of the study was longitudinal, including four repeated assessments during the war and post-war period (1993, 1995, 2000, and 2004). The baseline assessme...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract:AIM:To determine the physical activity level of the Croatian population in different domains of everyday life. METHODS:A random stratified sample of 1032 Croatians aged 15 years and older was interviewed using the official Croatian long version of the International Physical Activity Questionnaire (IPAQ). Total physica...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2009.50.165
更新日期:2009-04-01 00:00:00
abstract:AIM:To test for differences in hemodynamic and analgesic properties in patients with breast cancer undergoing quadrantectomy with paravertebral block (PVB) induced with a solution of either one or two local anesthetics. METHOD:A prospective, single-center, randomized, double-blinded, controlled trial was conducted fro...
journal_title:Croatian medical journal
pub_type: 杂志文章,随机对照试验
doi:10.3325/cmj.2017.58.270
更新日期:2017-08-31 00:00:00
abstract::We investigated the circumstances of building of the Civic Hospital in Split in the light of new archival evidence. The study necessitated a thorough review of the older historiography and previously unpublished archival sources kept in the State Archives in Venice and Zadar. The findings showed that construction of t...
journal_title:Croatian medical journal
pub_type: 历史文章,杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract:AIM:To explore the economic justification for introducing ultrasound screening for developmental dysplasia of the hip in Croatia. METHODS:The analysis was based on the two formulas: that cost-benefit equals benefit/cost, and that net benefit equals benefit minus cost. Screening costs were expressed as a sum of trainin...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract:AIM:To assess the ability to work and employability of individuals taking part in opioid substitution treatment programs (OSTP). METHODS:The study was composed of two surveys. In the first survey, 237 of 480 patients enrolled in OSTP responded to the questionnaire about their employment status, opinion about employmen...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2008.49.842
更新日期:2008-12-01 00:00:00
abstract:AIM:To evaluate motoric intestinal disturbances during inflammation with Trichinella spiralis in rats as an experimental model. METHODS:We examined the changes in worm-positive (jejunum) and worm-free (ileum) intestinal segments of rats infected with T. spiralis. To investigate the relationship between structural and ...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
abstract::Using moral and empirical analysis, we analyzed and discussed the role of public health in prevention of war as well as its function during and after the war. The idea is to develop a theory and new strategy in the spirit of public health to improve practices in preserving and strengthening peace, to be prepared for t...
journal_title:Croatian medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2002-04-01 00:00:00
abstract:AIM:To compare primary and secondary wound reconstruction as a treatment method for Gustilo type III open tibial fractures. METHODS:Thirty-five consecutive patients with a Gustilo type III open tibial shaft fracture were treated and followed up for 3 years. The patients were divided into two groups depending on the tr...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract:AIM:To evaluate maternal and paternal smoking habits during pregnancy and determine their correlation with pregnancy complications and newborn status. METHODS:The study included 499 pregnant women who delivered at the Department of Obstetrics and Gynecology in Uludag University School of Medicine, over a period of one...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
abstract:AIM:To determine whether the students enrolled in the computer-based teaching program would take the final examination in pathology earlier than those who studied according to the previous traditional program. METHODS:The study included all medical students enrolled in the pathology course at the Zagreb University Sch...
journal_title:Croatian medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2005-06-01 00:00:00
abstract::Today the development of a unique professional language and publishing of professional and scientific publications is the basis of every profession, including the nursing profession. The task of the unique language specific to the nursing profession is to describe the nursing profession (to make it more familiar to th...
journal_title:Croatian medical journal
pub_type: 历史文章,杂志文章
doi:10.3325/cmj.2012.53.631
更新日期:2012-12-01 00:00:00
abstract:AIM:To determine whether a combination of cell targeting and sequence recognition of nucleic acids can provide specificity for the inhibition of viral gene expression. METHODS:Antisense oligonucleotides complexed to a protein-based DNA carrier system were used to target hepatocytes for the inhibition of human hepatiti...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract:AIM:To assess the diagnostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in lung cancer (LC). We compared the ratios between healthy participants and all LC patients, as well patients with different pathohistological LC subtypes. METHODS:We retrieved the data on neutrophil, lym...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2016.57.287
更新日期:2016-06-30 00:00:00
abstract:AIM:To investigate what Zagreb University students think about professor-student dating. METHODS:We surveyed 500 students from ten different Zagreb University schools using anonymous questionnaires. Twenty-five female and 25 male students from each school were asked to assess professor-student dating as either accepta...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::For more than a century, since the introduction of modern hernia repair by Basinni, technical aspects of hernia surgery have been surrounded by controversies. The purpose of this article is to examine these controversies with special attention to (a) mechanical versus degenerative nature of hernias, (b) traditional ti...
journal_title:Croatian medical journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-03-01 00:00:00
abstract:AIM:To determine the stimulation site of both facial and hypoglossal nerves after transcranial magnetic stimulation. METHODS:After surgical exposure of the brainstem in 22 patients with intrinsic pontine (n=9) or medullary (n=13) tumors, the facial colliculus and the hypoglossal triangle were electrically stimulated. ...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:AIM:To assess the relationship between cognitive functions, severity of depressive symptoms, and expression of interleukin 1 (IL)-1 in patients treated with systemic anticancer therapy. METHODS:This prospective study, conducted in 2017-2018, involved 55 patients (56% men) subjected to systemic anticancer therapy. Fort...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2019-04-30 00:00:00
abstract::Two closely related boys from the same house hold (Home 1), aged two and three, were affected with fulminant meningococcal sepsis known as Waterhouse-Friderichsen syndrome. Neisseria meningitidis serogorup B was isolated from their blood and cerebrospinal fluid. The two-year-old boy died one day after the onset of the...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:AIM:To determine the prevalence of human immunodeficiency virus (HIV) infection in high-risk groups, ie, injecting drug users, patients with sexually transmitted infections, and men who have sex with men, and compare it with the prevalence determined in low-risk group, ie, pregnant women. METHODS:Residual sera from sp...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::To examine ways of ensuring access to health services within the framework of primary health care (PHC), since the goal of PHC to make universal health care available to all people has become increasingly neglected amid emerging themes of globalization, trade, and foreign policy. From a public health point of view, we...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/2010.51.181
更新日期:2010-06-01 00:00:00
abstract:AIM:To evaluate successes in the clinical management of severe diarrheal diseases in a busy referral hospital in Ghana, four years after the introduction of the World Health Organization's protocol for the clinical management of diarrhea and the establishment of an oral rehydration therapy Corner. METHOD:Data on the c...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::We analyzed forensic DNA samples from four cases of sexual assault, using the Y-chromosome-specific human DNA markers and a panel of autosomal short tandem repeats (STRs). The presence of male contribution was evaluated by the analysis of the Amelogenin locus. A panel of tetrameric Y-STR (DYS19, DYS390, DYS391, DYS392...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract:AIM:To validate the Croatian version of the Zarit Burden Interview (ZBI) and to investigate the predictors of perceived burden. METHODS:This cross-sectional study involved 131 dyads of one informal caregiver family member and one patient with dementia visiting primary care practices (Health Care Center Zagreb-West; 10...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2020-12-31 00:00:00
abstract:AIM:To provide a screening tool to reduce time and sample consumption when attempting mitochondrial DNA (mtDNA) haplogroup typing. METHODS:A single base primer extension assay was developed to enable typing, in a single reaction, of twelve mtDNA haplogroup specific polymorphisms. For validation purposes a total of 147...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract::Photolysis or "uncaging" of caged compounds represents a significant tool in cell biology and chemistry. It provides a means for quantitative control of compound delivery with temporal and spatial resolution while observing their consequences for cellular signaling. We discuss the use of ultraviolet-transmitting optic...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::A study was conducted to determine if modern forensic DNA typing methods can be properly employed throughout the world with a final goal of increasing arrests, prosecutions, and convictions of perpetrators of modern day trafficking in persons while concurrently reducing the burden of victim testimony in legal proceedi...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2014.55.3
更新日期:2014-02-01 00:00:00
abstract:AIM:To determine the association of carotid atherosclerosis and right ventricular diastolic dysfunction (DD) among treated hypertensive Nigerian patients. METHODS:This was a single center cross-sectional study performed at the Cardiology Clinic of LAUTECH Teaching Hospital, Ogbomoso, Nigeria between January and Decemb...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2013.54.555
更新日期:2013-12-01 00:00:00
abstract:AIM:To examine the feasibility of using peer review for the quality control of online materials. METHODS:We analyzed the inter-rater agreement on the quality of epidemiological lectures online, based on the Global Health Network Supercourse lecture library. We examined the agreement among reviewers by looking at kappa...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::Promising research developments in both basic and applied sciences, such as genomics and participatory health care approaches, have generated widespread interest in personalized medicine among almost all scientific areas and clinicians. The term personalized medicine is, however, frequently used without defining a cle...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2012.53.301
更新日期:2012-08-01 00:00:00