Abstract:
AIM:To evaluate motoric intestinal disturbances during inflammation with Trichinella spiralis in rats as an experimental model. METHODS:We examined the changes in worm-positive (jejunum) and worm-free (ileum) intestinal segments of rats infected with T. spiralis. To investigate the relationship between structural and functional changes in smooth muscle, we measured the thickness of the muscle layers of rat jejunum and ileum. Mechanical responses to KCl 30 mmol/L, acetylcholine (ACh) 10(-8)-10(-4) mol/L, substance P (SP) 10(-9)-10(-5) mol/L, and to electrical field stimulation of longitudinal muscle strips in the jejunum and ileum were studied in muscle bath as controls (day 0) and on day 2, 6, 14, 23, and 72 after infection. RESULTS:After T. spiralis infestation, an inflammation of the mucosal and submucosal layers of jejunum was observed, whereas in the worm-free ileum there was not any inflammatory infiltrate. Increase in the smooth muscle thickness of both jejunum and ileum were correlated with increased responses to depolarizing agent KCl and to ACh. However, responses to SP were decreased on day 14-23 after infection in jejunum and from day 6-14 after infection in ileum. Electric field stimulation-induced contractions were transiently decreased in the jejunum (day 2 after infection) but in the ileum the contractile responses were decreased until the end of the study period. CONCLUSIONS:Alterations in intestinal smooth muscle function do not require the presence of the parasite and the absence of histopathological signs of inflammation do not warrant intact motor function. Changes in motor responses after T. spiralis infection are not only due to smooth muscle damage but also to disturbances in specific receptor-mediated mechanisms.
journal_name
Croat Med Jjournal_title
Croatian medical journalauthors
Tanović A,Fernández E,Jiménez Msubject
Has Abstractpub_date
2006-04-01 00:00:00pages
318-26issue
2eissn
0353-9504issn
1332-8166journal_volume
47pub_type
杂志文章abstract::A radical primary health care-oriented reform of the medical services in Albania is now under way, calling for adequate revision in medical education. The reform has started in 1994. In January 1997, the Department of Family Medicine at the Faculty of Medicine, University of Tirana, was established for the development...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract:AIM:To examine the usefulness of molecular analysis of IgH gene rearrangement in assessment of clonality in bone marrow biopsies with lymphoid aggregates (LA) and/or nodular lymphoid hyperplasia (NLH) in patients with different subtypes of malignant lymphomas. METHOD:Five hundred and twenty nine samples of bone marrow...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
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journal_title:Croatian medical journal
pub_type: 历史文章,杂志文章
doi:
更新日期:2006-02-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 历史文章,杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract:: ...
journal_title:Croatian medical journal
pub_type: 社论
doi:
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2008.2.243
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::The Faculty of Medicine in Tirana, the only institution providing medical training in Albania, has currently developed three separate branches of study, General Medicine, Dentistry, and Pharmacy. Since the early 1990s, following the collapse of the communist regime, many faculty members have been trained abroad in dif...
journal_title:Croatian medical journal
pub_type: 杂志文章
doi:
更新日期:2005-02-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2011.52.550
更新日期:2011-08-15 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2013.54.206
更新日期:2013-04-01 00:00:00
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journal_title:Croatian medical journal
pub_type: 杂志文章
doi:10.3325/cmj.2011.52.344
更新日期:2011-06-01 00:00:00
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journal_title:Croatian medical journal
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doi:
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pub_type: 杂志文章,评审
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更新日期:2002-10-01 00:00:00
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doi:
更新日期:2002-04-01 00:00:00
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doi:10.3325/cmj.2016.57.558
更新日期:2016-12-31 00:00:00
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pub_type: 杂志文章
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