Alterations in intestinal contractility during inflammation are caused by both smooth muscle damage and specific receptor-mediated mechanisms.

Abstract:

AIM:To evaluate motoric intestinal disturbances during inflammation with Trichinella spiralis in rats as an experimental model. METHODS:We examined the changes in worm-positive (jejunum) and worm-free (ileum) intestinal segments of rats infected with T. spiralis. To investigate the relationship between structural and functional changes in smooth muscle, we measured the thickness of the muscle layers of rat jejunum and ileum. Mechanical responses to KCl 30 mmol/L, acetylcholine (ACh) 10(-8)-10(-4) mol/L, substance P (SP) 10(-9)-10(-5) mol/L, and to electrical field stimulation of longitudinal muscle strips in the jejunum and ileum were studied in muscle bath as controls (day 0) and on day 2, 6, 14, 23, and 72 after infection. RESULTS:After T. spiralis infestation, an inflammation of the mucosal and submucosal layers of jejunum was observed, whereas in the worm-free ileum there was not any inflammatory infiltrate. Increase in the smooth muscle thickness of both jejunum and ileum were correlated with increased responses to depolarizing agent KCl and to ACh. However, responses to SP were decreased on day 14-23 after infection in jejunum and from day 6-14 after infection in ileum. Electric field stimulation-induced contractions were transiently decreased in the jejunum (day 2 after infection) but in the ileum the contractile responses were decreased until the end of the study period. CONCLUSIONS:Alterations in intestinal smooth muscle function do not require the presence of the parasite and the absence of histopathological signs of inflammation do not warrant intact motor function. Changes in motor responses after T. spiralis infection are not only due to smooth muscle damage but also to disturbances in specific receptor-mediated mechanisms.

journal_name

Croat Med J

journal_title

Croatian medical journal

authors

Tanović A,Fernández E,Jiménez M

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

318-26

issue

2

eissn

0353-9504

issn

1332-8166

journal_volume

47

pub_type

杂志文章
  • Medical education in Albania: current situation and perspective, with reference to primary care.

    abstract::A radical primary health care-oriented reform of the medical services in Albania is now under way, calling for adequate revision in medical education. The reform has started in 1994. In January 1997, the Department of Family Medicine at the Faculty of Medicine, University of Tirana, was established for the development...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Rrumbullaku L,Theodorakis PN,Caca P,Lionis C,Trell E

    更新日期:2002-02-01 00:00:00

  • Bone marrow lymphoid aggregates in malignant lymphomas.

    abstract:AIM:To examine the usefulness of molecular analysis of IgH gene rearrangement in assessment of clonality in bone marrow biopsies with lymphoid aggregates (LA) and/or nodular lymphoid hyperplasia (NLH) in patients with different subtypes of malignant lymphomas. METHOD:Five hundred and twenty nine samples of bone marrow...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Dominis M,Pesut A,Borovecki A,Marusic-Vrsalovic M,Kusec R

    更新日期:2005-06-01 00:00:00

  • From a philanthropic idea to building of civic hospital in Split in light of new archival evidence.

    abstract::We investigated the circumstances of building of the Civic Hospital in Split in the light of new archival evidence. The study necessitated a thorough review of the older historiography and previously unpublished archival sources kept in the State Archives in Venice and Zadar. The findings showed that construction of t...

    journal_title:Croatian medical journal

    pub_type: 历史文章,杂志文章

    doi:

    authors: Brisky L,Fatović-Ferencić S

    更新日期:2006-02-01 00:00:00

  • Comparison of protective effects of catechin applied in vitro and in vivo on ischemia-reperfusion injury in the isolated rat hearts.

    abstract:AIM:To determine overall cardiac effects of flavonoid catechin on ischemia-reperfusion injury in isolated rat hearts in vitro and in vivo. METHODS:After perfusing hearts at the pressure of 70 mm Hg, coronary perfusion was interrupted for 30 minutes and then re-established. There were four experimental groups, with 10 ...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Modun D,Music I,Katalinic V,Salamunic I,Boban M

    更新日期:2003-12-01 00:00:00

  • Prediction of eye color in the Slovenian population using the IrisPlex SNPs.

    abstract:AIM:To evaluate the accuracy of eye color prediction based on six IrisPlex single nucleotide polymorphisms (SNP) in a Slovenian population sample. METHODS:Six IrisPlex predictor SNPs (HERC2 - rs12913832, OCA2 - rs1800407, SLC45A2 - rs16891982 and TYR - rs1393350, SLC24A4 - rs12896399, and IRF4 - rs12203592) of 105 ind...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2013.54.381

    authors: Kastelic V,Pośpiech E,Draus-Barini J,Branicki W,Drobnič K

    更新日期:2013-08-01 00:00:00

  • Graffiti - visual memory of Croatian history.

    abstract::Throughout the Middle Ages a unique Croatian Glagolitic script co-existed with Latin and western Cyrillic scripts, thus creating an open, large, and tolerant cultural environment. Many works common to European cultural heritage were translated into Croatian (Church Slavonic) language and preserved in the Glagolitic sc...

    journal_title:Croatian medical journal

    pub_type: 历史文章,杂志文章

    doi:

    authors: Fatović-Ferencić S,Duerrigl MA

    更新日期:1999-12-01 00:00:00

  • Editor ad interim - prospects and reality.

    abstract:: ...

    journal_title:Croatian medical journal

    pub_type: 社论

    doi:

    authors: Glasnović A

    更新日期:2018-12-31 00:00:00

  • When autosomal short tandem repeats fail: optimized primer and reaction design for Y-chromosome short tandem repeat analysis in forensic casework.

    abstract::Y-chromosomal short tandem repeats (Y-STRs) are useful forensic DNA markers in investigation of sexual assault cases when a mixture of male and female DNA (e.g., in vaginal swabs) is present in a sample, especially when DNA of the male contributor is present only in very small amount compared to the DNA of the female ...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Parson W,Niederstätter H,Köchl S,Steinlechner M,Berger B

    更新日期:2001-06-01 00:00:00

  • Cross-border alliances in health care: international co-operation between health insurers and providers in the Euregio Meuse-Rhine.

    abstract::On behalf of the European Commission, a Cross-Border Health Care Project was undertaken to explore how citizens living in the Euregio Meuse-Rhine can obtain improved access to health services in the Member States concerned: Belgium, Germany, and The Netherlands. Main attention of the project is focused on practical is...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Hermans HE,den Exter A

    更新日期:1999-06-01 00:00:00

  • Intramedullar stimulation of the facial and hypoglossal nerves: estimation of the stimulated site.

    abstract:AIM:To determine the stimulation site of both facial and hypoglossal nerves after transcranial magnetic stimulation. METHODS:After surgical exposure of the brainstem in 22 patients with intrinsic pontine (n=9) or medullary (n=13) tumors, the facial colliculus and the hypoglossal triangle were electrically stimulated. ...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Liscić RM,Morota N,Deletis V

    更新日期:2000-12-01 00:00:00

  • Impact of sociodemographic features of mothers on breastfeeding in Croatia: questionnaire study.

    abstract:AIM:To determine sociodemographic features that describe mothers who are likely to wean their babies earlier then is recommended and whether the rates of breast-fed children in Croatia had improved since 1996. METHODS:A sample of 500 mothers was selected from the population of women who had delivered 2 to 12 months be...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Berović N

    更新日期:2003-10-01 00:00:00

  • Congenital factor XI deficiency caused by a novel F11 missense variant: a case report.

    abstract::Hereditary factor XI (FXI) deficiency is a mild bleeding disorder, rare in the general population but relatively common among Ashkenazi Jews. The human F11 gene comprises 15 exons, spanning over 23 kb of the long arm of chromosome 4 (4q35). Homozygotes or compound heterozygotes typically show severe FXI deficiency, wh...

    journal_title:Croatian medical journal

    pub_type:

    doi:

    authors: Gotovac Jerčić K,Blažeković A,Hančević M,Bilić E,Borovečki F

    更新日期:2020-02-29 00:00:00

  • Epidemiology of bronchial asthma among schoolboys in Al-Khobar city, Saudi Arabia: cross-sectional study.

    abstract:AIM:To determine the prevalence of bronchial asthma among Saudi Arabian schoolboys living in Al-Khobar city. METHODS:Parents of 1,482 randomly selected boys in preparatory and elementary schools included in this cross-sectional study filled out a questionnaire on asthma signs in their sons. Number of Questionnaire-Dia...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Al-Dawood K

    更新日期:2000-12-01 00:00:00

  • Multi-type maltreatment in childhood and psychological adjustment in adolescence: questionnaire study among adolescents in Western Herzegovina Canton.

    abstract:AIM:To determine the prevalence and intercorrelation of different forms of childhood maltreatment and psychological problems in adolescents in Western Herzegovina Canton. METHOD:A questionnaire study was conducted in March 2003 on a convenient sample of 458 third-grade high-school students (39% boys) aged between 15 a...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2008.2.243

    authors: Sesar K,Zivcić-Bećirević I,Sesar D

    更新日期:2008-04-01 00:00:00

  • Transvaginal sonography of the fetal brain: detection of abnormal morphology and circulation.

    abstract:AIM:To analyze the incidence, transvaginal detection age, sonographic appearance, clinical course, and outcomes of pregnancy in cases with abnormal fetal brain structure and/or circulation, and to evaluate the clinical significance of sonographic abnormalities. METHODS:Serial observation of the fetal brain and intracr...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Pooh RK,Nakagawa Y,Nagamachi N,Pooh KH,Maeda K,Fukui R,Aono T

    更新日期:1998-06-01 00:00:00

  • Revitalization of academic medicine in Albania.

    abstract::The Faculty of Medicine in Tirana, the only institution providing medical training in Albania, has currently developed three separate branches of study, General Medicine, Dentistry, and Pharmacy. Since the early 1990s, following the collapse of the communist regime, many faculty members have been trained abroad in dif...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Roshi E,Burazeri G

    更新日期:2005-02-01 00:00:00

  • Health-related quality of life of women with disabilities in relation to their employment status.

    abstract:AIM:To compare the health-related quality of life of unemployed and employed women with disabilities and establish factors affecting their life satisfaction. METHODS:The study included 318 women with disabilities, 160 of whom were employed and 158 unemployed, paired according to age and region of residence. The health...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2011.52.550

    authors: Barisin A,Benjak T,Vuletić G

    更新日期:2011-08-15 00:00:00

  • Bio-objects' political capacity: a research agenda.

    abstract::This article explores the merits of foregrounding the dichotomy of politicization vs de-politicization for our understanding of bio-objects in order to study their production, circulation, and governance in European societies. By asking how bio-objects are configured in science, policy, public, and media discourses an...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2013.54.206

    authors: Maeseele P,Hendrickx K,Pavone V,Van Hoyweghen I

    更新日期:2013-04-01 00:00:00

  • Y-short tandem repeat haplotype and paternal lineage of the Ezhava population of Kerala, south India.

    abstract:AIM:To analyze the haplotype of the Ezhava population of Kerala, south India, using 8 short tandem repeat (STR) loci on the Y chromosome and trace the paternal genetic lineage of the population. METHODS:Whole blood samples (n=104) were collected from unrelated healthy men of the Ezhava population over a period of one ...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2011.52.344

    authors: Nair SP,Geetha A,Jagannath C

    更新日期:2011-06-01 00:00:00

  • Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes.

    abstract:AIM:To assess the diagnostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in lung cancer (LC). We compared the ratios between healthy participants and all LC patients, as well patients with different pathohistological LC subtypes. METHODS:We retrieved the data on neutrophil, lym...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2016.57.287

    authors: Nikolić I,Kukulj S,Samaržija M,Jeleč V,Žarak M,Orehovec B,Taradi I,Romić D,Kolak T,Patrlj L

    更新日期:2016-06-30 00:00:00

  • Ability to work and employability of patients in opioid substitution treatment programs in Slovenia.

    abstract:AIM:To assess the ability to work and employability of individuals taking part in opioid substitution treatment programs (OSTP). METHODS:The study was composed of two surveys. In the first survey, 237 of 480 patients enrolled in OSTP responded to the questionnaire about their employment status, opinion about employmen...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2008.49.842

    authors: Bilban M,Kastelic A,Zaletel-Kragelj L

    更新日期:2008-12-01 00:00:00

  • Up-regulation of Synaptotagmin IV within amyloid plaque-associated dystrophic neurons in Tg2576 mouse model of Alzheimer's disease.

    abstract:AIM:To investigate the involvement of the vesicular membrane trafficking regulator Synaptotagmin IV (Syt IV) in Alzheimer's disease pathogenesis and to define the cell types containing increased levels of Syt IV in the β-amyloid plaque vicinity. METHODS:Syt IV protein levels in wild type (WT) and Tg2576 mice cortex we...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2013.54.419

    authors: Tratnjek L,Zivin M,Glavan G

    更新日期:2013-10-28 00:00:00

  • Oncostatin-M in myocardial ischemia/reperfusion injury may regulate tissue repair.

    abstract:AIM:Oncostatin-M, a member of the gp 130 family of cytokines, has been associated with inflammation, connective tissue production, and extracellular matrix turnover. Since the reperfused heart is associated with an intense inflammatory reaction followed by scar formation, we tested the hypothesis that oncostatin-M is u...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Gwechenberger M,Moertl D,Pacher R,Huelsmann M

    更新日期:2004-04-01 00:00:00

  • A proposed role for efflux transporters in the pathogenesis of hydrocephalus.

    abstract::Hydrocephalus is a common brain disorder that is treated only with surgery. The basis for surgical treatment rests on the circulation theory. However, clinical and experimental data to substantiate circulation theory have remained inconclusive. In brain tissue and in the ventricles, we see that osmotic gradients drive...

    journal_title:Croatian medical journal

    pub_type: 杂志文章,评审

    doi:10.3325/cmj.2014.55.366

    authors: Krishnamurthy S,Tichenor MD,Satish AG,Lehmann DB

    更新日期:2014-08-28 00:00:00

  • The World Health Organization classification of lymphomas.

    abstract::The Revised European-American Classification of Lymphoid Neoplasms (REAL) classification has been validated by a multi-institutional study, and project data showed that it is both reproducible and clinically relevant. The new World Health Organization (WHO) Classification of Neoplastic Diseases of Hematopoietic and Ly...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Jakić-Razumović J,Aurer I

    更新日期:2002-10-01 00:00:00

  • Ethics competences in the undergraduate medical education curriculum: the Spanish experience.

    abstract::Aim .To investigate if there are differences in medical ethics education between different schools of medicine in Spain, specifically between private and public schools and between recently founded schools and older ones. METHOD:The curricula of medical degrees from all Spanish faculties were reviewed for the 2014/20...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2016.57.493

    authors: Ferreira-Padilla G,Ferrández-Antón T,Lolas-Stepke F,Almeida-Cabrera R,Brunet J,Bosch-Barrera J

    更新日期:2016-10-31 00:00:00

  • Y-chromosome short tandem repeat intermediate variant alleles DYS392.2, DYS449.2, and DYS385.2 delineate new phylogenetic substructure in human Y-chromosome haplogroup tree.

    abstract:AIM:To determine the human Y-chromosome haplogroup backgrounds of intermediate-sized variant alleles displayed by short tandem repeat (STR) loci DYS392, DYS449, and DYS385, and to evaluate the potential of each intermediate variant to elucidate new phylogenetic substructure within the human Y-chromosome haplogroup tree...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2009.50.239

    authors: Myres NM,Ritchie KH,Lin AA,Hughes RH,Woodward SR,Underhill PA

    更新日期:2009-06-01 00:00:00

  • Psychological status of Sarajevo children after war: 1999-2000 survey.

    abstract:AIM:To make a survey of children's health and psychosocial needs after the 1992-1995 war in Sarajevo, Bosnia and Herzegovina. METHODS:Representative samples of school-age children (n=310) from 6 public schools in the Sarajevo Canton, their parents (n=280), and teachers (n=156) were surveyed by means of self-administer...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Baràth A

    更新日期:2002-04-01 00:00:00

  • Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome.

    abstract:AIM:To test the hypothesis that tSSEP findings reflect clinical and MRI MS lesions, the aim of this study was to investigate tSSEP changes in patients with clinically isolated syndrome (CIS) in relation to clinical and brainstem MRI findings. The second aim was to investigate whether the interpretation of the tSSEP res...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2016.57.558

    authors: Krbot Skorić M,Adamec I,Crnošija L,Gabelić T,Barun B,Zadro I,Butković Soldo S,Habek M

    更新日期:2016-12-31 00:00:00

  • Kidney transplantation using a colon pouch (Mainz pouch III): a case report.

    abstract::Kidney transplantation is the most efficient method of renal replacement therapy. When this method is performed, native urinary bladder is the preferred urinary reservoir. However, in some patients with an anatomically and functionally abnormal lower urinary tract, the urinary bladder cannot be used for transplantatio...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Markić D,Oguić R,Krpina K,Gršković A,Vukelić I,Rački S,Ivančić A,Primc D,Španjol J

    更新日期:2019-12-31 00:00:00