Abstract：
:Hydrocephalus is a common brain disorder that is treated only with surgery. The basis for surgical treatment rests on the circulation theory. However, clinical and experimental data to substantiate circulation theory have remained inconclusive. In brain tissue and in the ventricles, we see that osmotic gradients drive water diffusion in water-permeable tissue. As the osmolarity of ventricular CSF increases within the cerebral ventricles, water movement into the ventricles increases and causes hydrocephalus. Macromolecular clearance from the ventricles is a mechanism to establish the normal CSF osmolarity, and therefore ventricular volume. Efflux transporters, (p-glycoprotein), are located along the blood brain barrier and play an important role in the clearance of macromolecules (endobiotics and xenobiotics) from the brain to the blood. There is clinical and experimental data to show that macromolecules are cleared out of the brain in normal and hydrocephalic brains. This article summarizes the existing evidence to support the role of efflux transporters in the pathogenesis of hydrocephalus. The location of p-gp along the pathways of macromolecular clearance and the broad substrate specificity of this abundant transporter to a variety of different macromolecules are reviewed. Involvement of p-gp in the transport of amyloid beta in Alzheimer disease and its relation to normal pressure hydrocephalus is reviewed. Finally, individual variability of p-gp expression might explain the variability in the development of hydrocephalus following intraventricular hemorrhage.
journal_name
Croat Med Jjournal_title
Croatian medical journalauthors
Krishnamurthy S,Tichenor MD,Satish AG,Lehmann DBdoi
10.3325/cmj.2014.55.366subject
Has Abstractpub_date
2014-08-28 00:00:00pages
366-76issue
4eissn
0353-9504issn
1332-8166journal_volume
55pub_type
杂志文章,评审abstract：:To examine ways of ensuring access to health services within the framework of primary health care (PHC), since the goal of PHC to make universal health care available to all people has become increasingly neglected amid emerging themes of globalization, trade, and foreign policy. From a public health point of view, we...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/2010.51.181
更新日期：2010-06-01 00:00:00
abstract：AIM:To determine whether and in what concentrations the underground waters, stream waters, spring water, and tap water from the Zagreb area contain phthalates -- compounds used as plastic softeners, which have recently been ascribed carcinogenic, mutagenic, and teratogenic effects. METHOD:The presence of dimethyl phth...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：AIM:To determine the prevalence of bronchial asthma among Saudi Arabian schoolboys living in Al-Khobar city. METHODS:Parents of 1,482 randomly selected boys in preparatory and elementary schools included in this cross-sectional study filled out a questionnaire on asthma signs in their sons. Number of Questionnaire-Dia...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：AIM:To analyze the success of three different treatment modalities for heroin addiction: methadone therapy, hospital therapy without methadone, and therapeutic community. METHODS:Ninety heroin addicts from the city of Split, Croatia, were systematically allocated to three groups, with 30 participants each, according t...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：AIM:To assess the effectiveness of the long-term group psychotherapy in the treatment of posttraumatic stress disorder (PTSD) in war veterans on the basis of clinical picture of PTSD, associated neurotic symptoms, and adopted models of psychological defense mechanisms. METHODS:Prospective cohort study involved 59 war ...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：AIM:To determine the diagnostic yield and criteria that could help to classify and interpret the copy number variations (CNVs) detected by chromosomal microarray (CMA) technique in patients with congenital and developmental abnormalities including dysmorphia, developmental delay (DD) or intellectual disability (ID), au...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2017.58.231
更新日期：2017-06-14 00:00:00
abstract：AIM:To present two patients with basaloid squamous cell carcinoma of the larynx, a rare, highly aggressive variant of the squamous cell carcinoma. METHODS:Surgical excision of the polypoid tumor of the anterior comissure of the larynx was performed in a 62 year-old male, and in the second case, total laryngectomy with...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Photolysis or "uncaging" of caged compounds represents a significant tool in cell biology and chemistry. It provides a means for quantitative control of compound delivery with temporal and spatial resolution while observing their consequences for cellular signaling. We discuss the use of ultraviolet-transmitting optic...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：AIM:To evaluate the effectiveness of suture anchors in the reconstruction of chronic collateral ligaments of fingers. METHODS:We treated 8 patients, 6 with chronic instability of the collateral ligament of the thumb and 2 with the instability of the fifth finger, using the Statak suture anchor. A stable joint was achi...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
abstract：AIM:Several amplification and detection formats for the analysis of short tandem repeat loci are readily available to the forensic laboratory. Careful consideration must be given to the throughput, sensitivity, concordance, data interpretation, facility requirements, and costs of operation. The Pennsylvania State Polic...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：AIM:To investigate the correlation between the length of the title of a scientific article and the number of citations it receives, in view of the common editorial call for shorter titles. METHODS:Title and the number of citations to all articles published in 2005 in 22 arbitrarily chosen English-language journals (n=...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2010.51.165
更新日期：2010-04-01 00:00:00
abstract：AIM:To estimate the incidence of postural orthostatic tachycardia syndrome (POTS) in the population of Zagreb, Croatia, and to determine the patients' demographic and clinical characteristics. METHODS:From 2012-2017, we identified patients with POTS by a retrospective analysis of medical records at University Hospital...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2020-10-31 00:00:00
abstract：AIM:To determine the prevalence and intercorrelation of different forms of childhood maltreatment and psychological problems in adolescents in Western Herzegovina Canton. METHOD:A questionnaire study was conducted in March 2003 on a convenient sample of 458 third-grade high-school students (39% boys) aged between 15 a...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2008.2.243
更新日期：2008-04-01 00:00:00
abstract：AIM:To determine overall cardiac effects of flavonoid catechin on ischemia-reperfusion injury in isolated rat hearts in vitro and in vivo. METHODS:After perfusing hearts at the pressure of 70 mm Hg, coronary perfusion was interrupted for 30 minutes and then re-established. There were four experimental groups, with 10 ...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：AIM:To determine types and frequency of CAPN3 mutations in 29 unrelated Croatian families, analyzed during 6-year prospective and ongoing genetic and epidemiological study of muscular dystrophies in Croatia. METHODS:Mutation analysis included allele-specific polymerase chain reaction (PCR) or combination of PCR and re...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：AIM:To asses prevalence of essential arterial hypertension in family members of soldiers killed in 1992-1995 war in Bosnia and Herzegovina. METHODS:The study enrolled 1144 subjects who lost a family member in the war and 582 of their close neighbors who experienced no such loss. Data on their medical history and habit...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:Throughout the Middle Ages a unique Croatian Glagolitic script co-existed with Latin and western Cyrillic scripts, thus creating an open, large, and tolerant cultural environment. Many works common to European cultural heritage were translated into Croatian (Church Slavonic) language and preserved in the Glagolitic sc...
journal_title：Croatian medical journal
pub_type： 历史文章,杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:Alport syndrome (AS) is a genetically heterogenic, structural disorder of the glomerular basement membrane (GBM) due to the mutation of COL4A3, COL4A4, or COL4A5 genes, which clinically presents as progressive hematuric nephritis with ultrastructural changes of the GBM, high tone sensorineural hearing loss, and ocular...
journal_title：Croatian medical journal
pub_type：
doi：
更新日期：2019-10-31 00:00:00
abstract：AIM:To test antinociceptive properties of botulinum toxin type A (BTX-A) in rats with carrageenan- and capsaicin-induced pain and inflammation. METHODS:Pain was provoked with carrageenan (1%) or capsaicin (0.1%) injection into the plantar surface of the rat paw-pad. The effect of BTX-A 5 U/kg on carrageenan- and capsa...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
abstract：AIM:To evaluate thyroid function and the presence of antithyroid autoantibodies in patients with sarcoidosis, compared to patients with chronic obstructive pulmonary disease (controls). METHODS:Sera were obtained from 26 patients (19 women and 7 men) with active sarcoidosis, age and sex matched to 26 patients with dia...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：AIM:To evaluate psychosomatic complaints and depressive symptoms among civilians, refugees, and soldiers in the war and post-war period in Croatia. METHOD:The design of the study was longitudinal, including four repeated assessments during the war and post-war period (1993, 1995, 2000, and 2004). The baseline assessme...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
abstract：AIM:To compare the myocardial effects of cardioplegia by warm blood, tepid blood, and cold crystalloid during coronary artery bypass grafting (CABG). METHODS:Patients undergoing CABG surgery at Kaunas University Hospital between 2000 and 2004 were randomized into three groups (n=156), receiving a different method of c...
journal_title：Croatian medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2005-12-01 00:00:00
abstract：AIM:To analyze the main indicators of income inequality, objective and subjective poverty, material deprivation, and the role of public social transfers in the reduction of poverty in 15 old and 10 new member states of the European Union (EU), undergoing post-communist socio-economic transition, as well as in Croatia, ...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2007-10-01 00:00:00
abstract：:The Croatian Pharmaceutical Sector Reform Project was one component of a larger Health Reform Project financed by the World Bank. The Croatian government was concerned that Croatia appeared to spend more money on medicinal drugs than most other countries in the region; that the price of drugs purchased in Croatia was ...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：AIM:To investigate missed opportunities to reveal existing but not formerly diagnosed coronary heart disease cases and related risk factors in primary health care. METHODS:The study comprised 850 people aged over 30 years with no known history of coronary heart disease, receiving health services from a primary care ce...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2007-06-01 00:00:00
abstract：:This article explores the merits of foregrounding the dichotomy of politicization vs de-politicization for our understanding of bio-objects in order to study their production, circulation, and governance in European societies. By asking how bio-objects are configured in science, policy, public, and media discourses an...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2013.54.206
更新日期：2013-04-01 00:00:00
abstract：:The attainment of the fifth Millennium Development Goal requires adequate national reserves of skilled birth attendants. Nurses, midwives, and their equivalents form the frontline of the formal health system are a critical element of global efforts to reduce ill-health and poverty in the poorest areas of the world. Pl...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2008.3.318
更新日期：2008-06-01 00:00:00
abstract：AIM:To assess the seroprevalence of human metapneumovirus (hMPV) in Croatia. METHODS:During 2005, a total of 137 serum specimens from Croatian patients aged from 6 days to 51 years, without respiratory symptoms, were collected at the Croatian National Institute of Public Health. The sera were examined using the indire...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：AIM:To test for differences in hemodynamic and analgesic properties in patients with breast cancer undergoing quadrantectomy with paravertebral block (PVB) induced with a solution of either one or two local anesthetics. METHOD:A prospective, single-center, randomized, double-blinded, controlled trial was conducted fro...
journal_title：Croatian medical journal
pub_type： 杂志文章,随机对照试验
doi：10.3325/cmj.2017.58.270
更新日期：2017-08-31 00:00:00
abstract：: ...
journal_title：Croatian medical journal
pub_type： 社论
doi：
更新日期：2018-12-31 00:00:00
