99Tcm-MAG3 for quantitation of differential renal function.

Abstract:

:We studied two different methods for the evaluation of differential renal function in a group of 100 patients with various kidney disorders whose effective renal plasma flow (ERPF) had been calculated previously by single 125I-orthoiodohippurate (OIH) injection and multiple blood sampling. Patients were divided into three groups according to their ERPF:ERPF is greater than or equal to 250 ml min-1; ERPF less than or equal to 100 ml min-1; and ERPF greater than 100 ml min-1 and less than 250 ml min-1. The two methods used to assess differential renal function were: first, relative 99Tcm-dimercaptosuccinic acid (DMSA) uptake calculated by normalized background and attenuation corrected cumulative counts in each kidney 24 h p.i.; and second, relative 99Tcm-mercaptoacetyl-triglycine (MAG3) uptake within 1 and 2 min p.i. calculated by normalized background and attenuation corrected counts on each renal area. The results obtained with each method correlated strongly with high significance (p less than 0.0001). In the right kidney, mean values obtained with 99Tcm-MAG3 tend to be higher than mean values obtained with 99Tcm-DMSA.

journal_name

Nucl Med Commun

authors

Llamas-Elvira JM,Martinez-Paredes M,Jimenez-Heffernan A,Sopena R,Requena MJ,Gonzalez FM,Torres M,Mateo A

doi

10.1097/00006231-198910000-00008

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

759-64

issue

10

eissn

0143-3636

issn

1473-5628

journal_volume

10

pub_type

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