In vivo kinetics of 123I-labelled insulin: studies in normal subjects and patients with diabetes mellitus.

Abstract:

:Radioactive tracer techniques using 131I- and 125I-insulin have been applied to study insulin metabolism. A simple method to label human insulin with 123I to a high specific activity is described. We have used this radiotracer to study insulin kinetics in vivo in normal subjects and in two groups of diabetic patients. The rate of decline in plasma radioactivity was shown to be significantly reduced in patients with diabetes. There were no significant differences in the time-activity profiles of liver and kidneys between the groups studied. This technique may provide insight into the mechanism of some forms of insulin resistance.

journal_name

Nucl Med Commun

authors

Sinclair AJ,Signore A,Bomanji J,Britton KE,Pozzilli P,Gale EA

doi

10.1097/00006231-198710000-00003

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

779-86

issue

10

eissn

0143-3636

issn

1473-5628

journal_volume

8

pub_type

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