Abstract:
:Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia who was treated with the sustained-release form of 4-aminopyridine (4-AP). During treatment with 4-AP, the LUTS improved. This improvement was monitored by using uroflowmetry and the International Prostate Symptom Score. A significant improvement of symptoms was observed in relation to the voided volume. This included an improved emptying of the bladder without an increase in residual urine. In animal studies, both nonselective K(+) channel blockade and selective voltage-sensitive potassium blockade by 4-AP resulted in increased contraction on rat detrusor strips. To our knowledge, this is the first clinical observation of the mode of action of 4-AP in urological symptoms in humans.
journal_name
Int Neurourol Jjournal_title
International neurourology journalauthors
Strupp M,Feil K,Bardins S,Waidelich Rdoi
10.5213/inj.2014.18.4.221subject
Has Abstractpub_date
2014-12-01 00:00:00pages
221-5issue
4eissn
2093-4777issn
2093-6931journal_volume
18pub_type
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