Abstract:
PURPOSE:To evaluate whether hydrodistention with fulguration of Hunner lesions (HD/FUL) plus maintenance dimethyl sulfoxide (DMSO) therapy prolongs the recurrence-free time in patients with Hunner type interstitial cystitis (IC). METHODS:The study enrolled patients with Hunner type IC who required repeat HD/FUL due to recurrence of IC symptoms after the first HD/FUL at our institution. All patients received a second HD/FUL plus maintenance DMSO therapy. The maintenance DMSO therapy was performed every 2 weeks for a total of 8 instillations, and then once every 4 weeks thereafter. The recurrencefree time from HD/FUL to therapeutic failure was estimated using the Kaplan-Meier method. The recurrence-free time between the first HD/FUL and second HD/FUL plus maintenance DMSO therapy was statistically compared using the log-rank test. RESULTS:A total of 21 patients (mean age, 66.3±10.8 years) with Hunner type IC were evaluated. The recurrence-free time for the second HD/FUL plus maintenance DMSO therapy was significantly longer than that for the first HD/FUL (P<0.0001). The median recurrence-free time for the first HD/FUL was 10.1 months, while that for the second HD/FUL plus maintenance DMSO therapy has yet to be reached. The recurrence-free rate for the first HD/FUL was 81.0% at 6 months, 38.1% at 1 year, 9.5% at 2 years, and 4.8% at 3 years. In contrast, the rate for the second HD/FUL plus maintenance DMSO therapy was 100% at 6 months, 94.7% at 1 year, 82.6% at 2 years, and 82.6% at 3 years. There were no significant differences in efficacy between the first and second HD/FUL. CONCLUSION:HD/FUL plus maintenance DMSO therapy clearly prolongs the recurrence-free time compared with HD/FUL alone in Hunner type IC.
journal_name
Int Neurourol Jjournal_title
International neurourology journalauthors
Otsuka A,Suzuki T,Matsushita Y,Watanabe H,Tamura K,Motoyama D,Ito T,Sugiyama T,Miyake Hdoi
10.5213/inj.1938110.055subject
Has Abstractpub_date
2019-12-01 00:00:00pages
327-333issue
4eissn
2093-4777issn
2093-6931pii
inj.1938110.055journal_volume
23pub_type
杂志文章abstract:PURPOSE:To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms. METHODS:We performed a retrospective chart review of all PD patients who were seen in an outpatient clinic for lower urinary tract symptoms (LUTS) between 2010 and 2017 in a single-institution. Only pati...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938086.043
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Recently, reports in the mass media have implicated that bicycle riding increases the risk of erectile dysfunction and prostatic diseases. So, we evaluate the impact of bicycle riding on erectile function and lower urinary tract symptoms (LUTS) in healthy general men. METHODS:From 26 June 2010 to 20 July 2010,...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.2.97
更新日期:2011-06-01 00:00:00
abstract::[This corrects the article on p. 122 in vol. 20, PMID: 27377944.]. ...
journal_title:International neurourology journal
pub_type: 已发布勘误
doi:10.5213/inj.1620err.002
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:This study reports the development of the Korean Version of the Treatment Satisfaction Visual Analogue Scale (TS-VAS) and the Overactive Bladder Satisfaction with Treatment Questionnaire (OAB-SAT-q) based on the original versions, with subsequent linguistic validation by Korean patients with overactive bladder ...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1734992.496
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:We studied the influence of preoperative bladder outlet obstruction (BOO) on postoperative continence rates and patient satisfaction after the midurethral sling procedure. METHODS:A total of 159 women who underwent the midurethral sling procedure were evaluated. Using the Blaivas-Groutz nomogram, we assigned t...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.267
更新日期:2010-12-01 00:00:00
abstract::In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance. The purpose of this review is to summarize the current state of knowledge about mechanisms and potential appli...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.203
更新日期:2010-12-01 00:00:00
abstract::Our aim was to report the first case of computer-assisted lead placement (CALP) for a peripheral nerve evaluation (PNE) test in a 55-year-old woman affected by chronic pelvic pain, who was a candidate for sacral neuromodulation (SNM). The first PNE test failed due to nonoptimal lead placement. We utilized a surgical n...
journal_title:International neurourology journal
pub_type:
doi:10.5213/inj.2040096.048
更新日期:2020-12-01 00:00:00
abstract:Purpose:This study aimed to evaluate the accuracy and reliability of a new smartphone-based acoustic uroflowmetry compared to conventional uroflowmetry. Methods:This was a prospective validation study enrolling 128 subjects from September 2017 to April 2018 comparing a novel acoustic uroflowmetry to conventional urofl...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2040250.125
更新日期:2021-01-04 00:00:00
abstract:PURPOSE:The purpose of this study was to review studies that have examined the quality of life of women with urinary incontinence. MATERIALS AND METHODS:A review was conducted that used the databases PubMED, Proquest, CINAHL, and Sciencedirect. Articles were included that were published in English between 2005 and 201...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.3.133
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess the current management status of patients with urological issues and to examine the level of knowledge and practice behaviors regarding urinary incontinence (UI) among Korean healthcare providers in long-term care hospitals. METHODS:This study used a cross-sectional desc...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.4.259
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To investigate the clinical factors associated with the feeling of incomplete bladder emptying in female patients with lower urinary tract symptoms (LUTS). METHODS:Records were obtained from a prospectively maintained database for 353 female patients without a history of treatment for LUTS. Patients with comor...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938256.128
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:We aimed to assess whether nerve-sparing radical prostatectomy (nsRP) is associated with improved recovery of urinary continence compared to non-nerve-sparing radical prostatectomy (nnsRP) in patients with localized prostate cancer and preoperative erectile dysfunction. METHODS:A total of 360 patients with org...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1630428.214
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of an alpha-1 adrenergic receptor (α1-AR) blocker for the treatment of female voiding dysfunction (FVD) through a pressure-flow study. METHODS:This was a randomized, double-blind, placebo-controlled trial. Women aged ≥18 years with voiding symptoms, as defined by an American Urological...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1834904.452
更新日期:2018-03-01 00:00:00
abstract::The apical surface of mammalian urinary epithelium is covered by numerous scallop-shaped membrane plaques. This plaque consists of four different uroplakins (UPs) and integral membrane proteins. UPs, which are a member of the tetraspanin superfamily, are assembled into plaques that act as an exceptional barrier to wat...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.1.4
更新日期:2011-03-01 00:00:00
abstract::The clinical success of mirabegron as the first β3-adrenoceptor (AR) agonist for treatment of the overactive bladder (OAB) syndrome, has resulted in substantial interest in its site and mechanism of action. Even if the adrenergic innervation of the bladder and urethra has been well studied, the location(s) of β3-ARs i...
journal_title:International neurourology journal
pub_type: 杂志文章,评审
doi:10.5213/inj.1734850.425
更新日期:2017-03-24 00:00:00
abstract::Lower urinary tract symptoms (LUTS) are a cluster of voiding symptoms, such as weak stream, hesitancy, intermittency, urinary frequency, urgency, and nocturia. LUTS are frequent in elderly men and it considered the ultimate clinical symptoms of benign prostatic hyperplasia. With aging, male hypogonadism is increased w...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2040234.117
更新日期:2021-01-19 00:00:00
abstract:PURPOSE:Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain. The aim of the present study was to investigate the neuroprotective effect and the regulating hypoxic induci...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938190.095
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:We investigated bladder function, with a special focus on nonvoiding contractions (NVCs), in awake rats with chronic chemical cystitis and bladder outlet obstruction (BOO) by use of simultaneous registrations of intravesical and intraabdominal pressures. In addition, we tested the effects of tolterodine on the ...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.3.120
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:Bladder wall thickness has been reported to be associated with overactive bladder (OAB) in women. Diabetic women have an increased risk for OAB syndrome and may have an increased risk for bladder wall thickness. METHODS:A total of 235 female patients aged 40 to 75 years were categorized into four groups. The f...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.2.67
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:Maintaining urinary continence at stress requires a competent urethral sphincter and good suburethral support. Sphincter competence is estimated by measuring the maximal urethral closure pressure at rest. We aimed to study the value of a new urodynamic measure, the urethral closure pressure at stress (s-UCP), i...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1732686.343
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction, or urinary incontinence due to pelvic muscle weakness induced by aging. Physical exercise has been recomme...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.2.77
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to characterize the responsiveness of miniature excitatory postsynaptic currents (mEPSCs) to α1-adrenoceptor blockers in substantia gelatinosa (SG) neurons from the spinal cord to develop an explanation for the efficacy of α1-adrenoceptor blockers in micturition dysfunction. METHODS:M...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938056.028
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Clean intermittent self-catheterization (CISC) is now considered the gold standard for the management of urinary retention. In the literature, several articles on patients' perspectives on CISC and adherence to this technique have been published. No studies have yet explored the points of view of professional c...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1734824.412
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To evaluate the effects of botulinum toxin on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity. METHODS:Thirty four adult patients with spinal cord injury and detrusor overactivity were selected. The patients received 300 units of botulinum toxin type A. The endpoints...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.3.139
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Traumatic brain injury (TBI) causes cognitive impairments, motor deficits, and neuropsychiatric/behavioral deficits problems. Transplantation of bone marrow stromal cells (BMSCs) facilitates functional recovery from brain insults. Treadmill exercise increases neurogenesis and inhibits apoptosis. In this study, ...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1632616.308
更新日期:2016-05-01 00:00:00
abstract::Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology, however it is not fully understood how this neurodegeneration is initiated and what precisely causes this disease. As...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1836216.108
更新日期:2018-10-01 00:00:00
abstract::Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingly point to distinct...
journal_title:International neurourology journal
pub_type: 杂志文章,评审
doi:10.5213/inj.1632752.376
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:Benign prostatic hyperplasia is often accompanied by age-related comorbidity, such as erectile dysfunction (ED). Recent data suggest an association between ED and lower urinary tract symptoms (LUTS), and increasing evidence indicates that the clinical use of phosphodiesterase type 5 (PDE5) inhibitors provides r...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.1.7
更新日期:2010-04-01 00:00:00
abstract::Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia who ...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.4.221
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:Lower urinary tract dysfunction is the most common complication after radical pelvic surgery. The aims of this study were to assess the effect of radical hysterectomy (RH) on the storage function of the lower urinary tract and to evaluate the impact of radiation therapy (RT) on postoperative urodynamic paramete...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.2.91
更新日期:2012-06-01 00:00:00