Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study.

Abstract:

PURPOSE:In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. METHODS:A total of 159 men (≥50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups according to their sympathetic activity, which was evaluated by heart ratevariability measurements. HSA was defined as a low frequency/high frequency ratio greater than 1.6. All patients received 10mg of alfuzosin once a day for 12 weeks. The primary end point was a change in the total International Prostate SymptomScore (IPSS) at 12 weeks from baseline. RESULTS:Sixty-seven men were assigned to the HSA group and 92 men were assigned to the LSA group. The baseline characteristics were not significantly different between the 2 groups, and the response to alfuzosin was good in both groups. Themean total IPSS change was not different between the groups. Both groups were not significantly different with respect to the changes in maximal flow rate, IPSS voiding or storage symptom subscores, quality of life, and rates of adverse drug events. TheHSA group showed a similar willingness to continue treatment compared to the LSA group, although their treatment satisfaction rating was lower. CONCLUSIONS:The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group.

journal_name

Int Neurourol J

authors

Park SG,Chung BH,Lee SW,Park JK,Park K,Cheon J,Lee KS,Kim HJ,Seong DH,Oh SJ,Kim SW,Lee JY,Choo SH,Choi JB

doi

10.5213/inj.2015.19.2.107

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

107-12

issue

2

eissn

2093-4777

issn

2093-6931

pii

inj-19-2-107

journal_volume

19

pub_type

杂志文章
  • Presynaptic Dysfunction by Familial Factors in Parkinson Disease.

    abstract::Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology, however it is not fully understood how this neurodegeneration is initiated and what precisely causes this disease. As...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1836216.108

    authors: Lee W,Koh S,Hwang S,Kim SH

    更新日期:2018-10-01 00:00:00

  • Increased bladder wall thickness in diabetic and nondiabetic women with overactive bladder.

    abstract:PURPOSE:Bladder wall thickness has been reported to be associated with overactive bladder (OAB) in women. Diabetic women have an increased risk for OAB syndrome and may have an increased risk for bladder wall thickness. METHODS:A total of 235 female patients aged 40 to 75 years were categorized into four groups. The f...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2013.17.2.67

    authors: Uzun H,Ogullar S,Sahin SB,Zorba OÜ,Akça G,Sümer F,Güney UM,Balık G

    更新日期:2013-06-01 00:00:00

  • Development of Decision Support Formulas for the Prediction of Bladder Outlet Obstruction and Prostatic Surgery in Patients With Lower Urinary Tract Symptom/Benign Prostatic Hyperplasia: Part I, Development of the Formula and its Internal Validation.

    abstract:PURPOSE:As the elderly population increases, a growing number of patients have lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH). The aim of this study was to develop decision support formulas and nomograms for the prediction of bladder outlet obstruction (BOO) and for BOO-related surgical decision-...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1734852.426

    authors: Choo MS,Yoo C,Cho SY,Jeong SJ,Jeong CW,Ku JH,Oh SJ

    更新日期:2017-04-01 00:00:00

  • Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials.

    abstract:PURPOSE:Transcutaneous electrical neural stimulation (TENS), as a non-invasive modality, has been clinically used as an alternative treatment for children with overactive bladder (OAB). We conducted a pooled analysis to explore the effect of TENS on OAB. METHODS:The Preferred Reporting Items for Systematic Reviews and...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1938232.116

    authors: Cui H,Yao Y,Xu Z,Gao Z,Wu J,Zhou Z,Cui Y

    更新日期:2020-03-01 00:00:00

  • Mechanisms and prospects of ischemic tolerance induced by cerebral preconditioning.

    abstract::In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance. The purpose of this review is to summarize the current state of knowledge about mechanisms and potential appli...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2010.14.4.203

    authors: Bhuiyan MI,Kim YJ

    更新日期:2010-12-01 00:00:00

  • Computer-Assisted Lead Placement for Peripheral Nerve Evaluation Test in a Candidate for Sacral Neuromodulation.

    abstract::Our aim was to report the first case of computer-assisted lead placement (CALP) for a peripheral nerve evaluation (PNE) test in a 55-year-old woman affected by chronic pelvic pain, who was a candidate for sacral neuromodulation (SNM). The first PNE test failed due to nonoptimal lead placement. We utilized a surgical n...

    journal_title:International neurourology journal

    pub_type:

    doi:10.5213/inj.2040096.048

    authors: Sampogna G,Montanari E,Spinelli M

    更新日期:2020-12-01 00:00:00

  • Clinical Factors Associated With the Feeling of Incomplete Bladder Emptying in Women With Little Postvoided Residue.

    abstract:PURPOSE:To investigate the clinical factors associated with the feeling of incomplete bladder emptying in female patients with lower urinary tract symptoms (LUTS). METHODS:Records were obtained from a prospectively maintained database for 353 female patients without a history of treatment for LUTS. Patients with comor...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1938256.128

    authors: Lee KS,Koo KC

    更新日期:2020-06-01 00:00:00

  • Population-based survey on disease insight, quality of life, and health-seeking behavior associated with female urinary incontinence.

    abstract:PURPOSE:To evaluate disease insight, personal distress, and healthcare-seeking behavior of women with urinary incontinence (UI) to improve women's health in Korea. METHODS:In October 2012, 500 Korean women residing around Seoul, Incheon, and Gyeonggi-do were selected by random sampling for a population-based cross-sec...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2015.19.1.39

    authors: Choi H,Park JY,Yeo JK,Oh MM,Moon du G,Lee JG,Bae JH

    更新日期:2015-03-01 00:00:00

  • Characterization on Responsiveness of Excitatory Synaptic Transmissions to α1-Adrenoceptor Blockers in Substantia Gelatinosa Neurons Isolated From Lumbo-Sacral Level in Rat Spinal Cords.

    abstract:PURPOSE:The aim of this study was to characterize the responsiveness of miniature excitatory postsynaptic currents (mEPSCs) to α1-adrenoceptor blockers in substantia gelatinosa (SG) neurons from the spinal cord to develop an explanation for the efficacy of α1-adrenoceptor blockers in micturition dysfunction. METHODS:M...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1938056.028

    authors: Uta D,Hattori T,Yoshimura M

    更新日期:2019-03-01 00:00:00

  • The influence of preoperative bladder outlet obstruction on continence and satisfaction in patients with stress urinary incontinence after midurethral sling.

    abstract:PURPOSE:We studied the influence of preoperative bladder outlet obstruction (BOO) on postoperative continence rates and patient satisfaction after the midurethral sling procedure. METHODS:A total of 159 women who underwent the midurethral sling procedure were evaluated. Using the Blaivas-Groutz nomogram, we assigned t...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2010.14.4.267

    authors: Kim SJ,Choi HW,Cho HJ,Hwang TK,Kim JC

    更新日期:2010-12-01 00:00:00

  • Urethral Closure Pressure at Stress: A Predictive Measure for the Diagnosis and Severity of Urinary Incontinence in Women.

    abstract:PURPOSE:Maintaining urinary continence at stress requires a competent urethral sphincter and good suburethral support. Sphincter competence is estimated by measuring the maximal urethral closure pressure at rest. We aimed to study the value of a new urodynamic measure, the urethral closure pressure at stress (s-UCP), i...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1732686.343

    authors: Pizzoferrato AC,Fauconnier A,Fritel X,Bader G,Dompeyre P

    更新日期:2017-06-01 00:00:00

  • Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells.

    abstract:PURPOSE:Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain. The aim of the present study was to investigate the neuroprotective effect and the regulating hypoxic induci...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1938190.095

    authors: Yoo SY,Yoo JY,Kim HB,Baik TK,Lee JH,Woo RS

    更新日期:2019-11-01 00:00:00

  • Knowledge and Practice Behaviors Regarding Urinary Incontinence Among Korean Healthcare Providers in Long-term Care Hospitals.

    abstract:PURPOSE:The purpose of this study was to assess the current management status of patients with urological issues and to examine the level of knowledge and practice behaviors regarding urinary incontinence (UI) among Korean healthcare providers in long-term care hospitals. METHODS:This study used a cross-sectional desc...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2015.19.4.259

    authors: Jang Y,Kwon BE,Kim HS,Lee YJ,Lee S,Kim SJ,Jeong CW,Kim KH

    更新日期:2015-12-01 00:00:00

  • The Efficacy of Continuous Positive Airway Pressure Therapy on Nocturia in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:To assess the efficacy of the continuous positive airway pressure (CPAP) on nocturia in patients with obstructive sleep apnea (OSA). METHODS:A literature review was performed to identify all published clinical trials of CPAP for the treatment of nocturia. The search included the following databases: MEDLINE, E...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2015.19.3.178

    authors: Wang T,Huang W,Zong H,Zhang Y

    更新日期:2015-09-01 00:00:00

  • Effects of Acute Sacral Neuromodulation at Different Pulse Widths on Bladder Overactivity in Pigs.

    abstract:PURPOSE:Sacral nerve stimulation has been used to treat overactive bladder. This study evaluated the effects of stimulation using different pulse widths on the inhibition of bladder overactivity by sacral nerve stimulation (SNM) in pigs. METHODS:Implant-driven stimulators were used to stimulate the S3 spinal nerve in ...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1938042.021

    authors: Cong H,Liao L,Wang Y,Zhao L,Wang Z,Fu G,Chen G

    更新日期:2019-06-01 00:00:00

  • Past, Present, and Future in the Study of Neural Control of the Lower Urinary Tract.

    abstract::The neurological coordination of the lower urinary tract can be analyzed from the perspective of motor neurons or sensory neurons. First, sensory nerves with receptors in the bladder and urethra transmits stimuli to the cerebral cortex through the periaqueductal gray (PAG) of the midbrain. Upon the recognition of stim...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2040318.159

    authors: Kim JW,Kim SJ,Park JM,Na YG,Kim KH

    更新日期:2020-09-01 00:00:00

  • Genetic and Epigenetic Alterations in Bladder Cancer.

    abstract::Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingly point to distinct...

    journal_title:International neurourology journal

    pub_type: 杂志文章,评审

    doi:10.5213/inj.1632752.376

    authors: Li HT,Duymich CE,Weisenberger DJ,Liang G

    更新日期:2016-11-01 00:00:00

  • Long-term Outcomes of Augmentation Cystoplasty in a Pediatric Population With Refractory Bladder Dysfunction: A 12-Year Follow-up Experience at Single Center.

    abstract:PURPOSE:Augmentation cystoplasty (AC) is a surgical procedure used in adults and children with refractory bladder dysfunction, including a small bladder capacity and inadequate bladder compliance, and in whom conservative and medical treatment has failed. This study was aimed to determine the long-term outcomes of AC i...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1836174.087

    authors: Mehmood S,Alhazmi H,Al-Shayie M,Althobity A,Alshammari A,Altaweel WM,Almathami A,Vallasciani S

    更新日期:2018-12-01 00:00:00

  • Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease.

    abstract:PURPOSE:To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms. METHODS:We performed a retrospective chart review of all PD patients who were seen in an outpatient clinic for lower urinary tract symptoms (LUTS) between 2010 and 2017 in a single-institution. Only pati...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1938086.043

    authors: Vurture G,Peyronnet B,Palma JA,Sussman RD,Malacarne DR,Feigin A,Palmerola R,Rosenblum N,Frucht S,Kaufmann H,Nitti VW,Brucker BM

    更新日期:2019-09-01 00:00:00

  • Overview of the Epidemiology of Lower Urinary Tract Dysfunction in South Korea.

    abstract::This review assessed the epidemiology of voiding dysfunctions in South Korea. Comprehensive understanding of this epidemiology is crucial because the senior population and the social burden are increasing because of voiding dysfunctions is growing. We searched the medical records using several terms related to voiding...

    journal_title:International neurourology journal

    pub_type: 杂志文章,评审

    doi:10.5213/inj.1630502.251

    authors: Choi H,Bae JH

    更新日期:2016-06-01 00:00:00

  • Neuroprotective Effects of Bone Marrow Stromal Cell Transplantation in Combination With Treadmill Exercise Following Traumatic Brain Injury.

    abstract:PURPOSE:Traumatic brain injury (TBI) causes cognitive impairments, motor deficits, and neuropsychiatric/behavioral deficits problems. Transplantation of bone marrow stromal cells (BMSCs) facilitates functional recovery from brain insults. Treadmill exercise increases neurogenesis and inhibits apoptosis. In this study, ...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1632616.308

    authors: Shin MS,Park HK,Kim TW,Ji ES,Lee JM,Choi HS,Kim MY,Kim YP

    更新日期:2016-05-01 00:00:00

  • Botulinum toxin in neurogenic detrusor overactivity.

    abstract:PURPOSE:To evaluate the effects of botulinum toxin on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity. METHODS:Thirty four adult patients with spinal cord injury and detrusor overactivity were selected. The patients received 300 units of botulinum toxin type A. The endpoints...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2012.16.3.139

    authors: D'Ancona CA,Ferreira RS,Rassi MC

    更新日期:2012-09-01 00:00:00

  • Unroofed midline prostate cyst misled into a stricture with obliterative bladder neck contracture following a laser prostatectomy.

    abstract::We report on a case of a 67-year-old man who presented with persistent lower urinary tract symptoms following a potassium titanyl phosphate laser photoselective vaporization of prostate. Upon further diagnostic examinations were performed, he was noted to have an obliterative bladder neck contracture with an incidenta...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2013.17.1.34

    authors: Diaz RR,Lee JY,Choi YD,Cho KS

    更新日期:2013-03-01 00:00:00

  • Neurologic Mechanisms Underlying Voiding Dysfunction due to Prostatitis in a Rat Model of Nonbacterial Prostatic Inflammation.

    abstract:PURPOSE:The neurological molecular mechanisms underlying the voiding dysfunction associated with nonbacterial chronic prostatitis/chronic pelvic pain syndrome remain poorly understood. In this study, we assessed whether prostate inflammation activated bladder afferent neurons, leading to bladder dysfunction, and sought...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.1836124.062

    authors: Park JS,Jin MH,Hong CH

    更新日期:2018-06-01 00:00:00

  • The Efficacy of Epidural Ketamine on Shivering during Transurethral Resection of the Prostate under Epidural Anesthesia.

    abstract:PURPOSE:Ketamine may decrease core-to-peripheral redistribution of heat through direct central sympathetic stimulation and inhibition of norepinephrine uptake into postganglionic sympathetic nerve endings. The purpose of this study was to evaluate the efficacy of epidural ketamine in preventing shivering during transur...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2010.14.2.105

    authors: Han DY,Jeong HJ,Lee C,Choi DH

    更新日期:2010-08-01 00:00:00

  • Correlation Between Testosterone-Replacement Treatment and Lower Urinary Tract Symptoms.

    abstract::Lower urinary tract symptoms (LUTS) are a cluster of voiding symptoms, such as weak stream, hesitancy, intermittency, urinary frequency, urgency, and nocturia. LUTS are frequent in elderly men and it considered the ultimate clinical symptoms of benign prostatic hyperplasia. With aging, male hypogonadism is increased w...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2040234.117

    authors: Lee MH,Shin YS,Kam SC

    更新日期:2021-01-19 00:00:00

  • Dissimilar effects of tolterodine on detrusor overactivity in awake rats with chemical cystitis and partial bladder outlet obstruction.

    abstract:PURPOSE:We investigated bladder function, with a special focus on nonvoiding contractions (NVCs), in awake rats with chronic chemical cystitis and bladder outlet obstruction (BOO) by use of simultaneous registrations of intravesical and intraabdominal pressures. In addition, we tested the effects of tolterodine on the ...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2011.15.3.120

    authors: Jin LH,Park CS,Shin HY,Yoon SM,Lee T

    更新日期:2011-09-01 00:00:00

  • Uroplakins in the lower urinary tract.

    abstract::The apical surface of mammalian urinary epithelium is covered by numerous scallop-shaped membrane plaques. This plaque consists of four different uroplakins (UPs) and integral membrane proteins. UPs, which are a member of the tetraspanin superfamily, are assembled into plaques that act as an exceptional barrier to wat...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2011.15.1.4

    authors: Lee G

    更新日期:2011-03-01 00:00:00

  • Aerobic exercise affects myostatin expression in aged rat skeletal muscles: a possibility of antiaging effects of aerobic exercise related with pelvic floor muscle and urethral rhabdosphincter.

    abstract:PURPOSE:Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction, or urinary incontinence due to pelvic muscle weakness induced by aging. Physical exercise has been recomme...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2014.18.2.77

    authors: Ko IG,Jeong JW,Kim YH,Jee YS,Kim SE,Kim SH,Jin JJ,Kim CJ,Chung KJ

    更新日期:2014-06-01 00:00:00

  • A Novel Mobile Acoustic Uroflowmetry: Comparison With Contemporary Uroflowmetry.

    abstract:Purpose:This study aimed to evaluate the accuracy and reliability of a new smartphone-based acoustic uroflowmetry compared to conventional uroflowmetry. Methods:This was a prospective validation study enrolling 128 subjects from September 2017 to April 2018 comparing a novel acoustic uroflowmetry to conventional urofl...

    journal_title:International neurourology journal

    pub_type: 杂志文章

    doi:10.5213/inj.2040250.125

    authors: Lee YJ,Kim MM,Song SH,Lee S

    更新日期:2021-01-04 00:00:00