Abstract:
PURPOSE:Traumatic brain injury (TBI) causes cognitive impairments, motor deficits, and neuropsychiatric/behavioral deficits problems. Transplantation of bone marrow stromal cells (BMSCs) facilitates functional recovery from brain insults. Treadmill exercise increases neurogenesis and inhibits apoptosis. In this study, we investigated the effects of BMSC transplantation in combination with treadmill exercise on memory function, by evaluating its effect on neurogenesis and apoptosis in the hippocampus following TBI. METHODS:TBI was induced using an electromagnetic-controlled cortical impact device. BMSCs were transplanted into both sides of traumatic scar region 1 week after TBI induction. One week after transplantation of BMSCs, the rats in the exercise groups were trained to run on a treadmill for 30 minutes once daily for 28 days. Step-down avoidance task and radial 8-arm maze test were conducted. Levels of 5-bromo-2ʹ-deoxyuridine and caspase-3 were evaluated using immunohistochemistry. Western blot was used to evaluate the expression of brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB), total-extracellular signal-regulated kinase 1 and 2 (t-ERK1/2), phosphorylated-ERK1/2 (p-ERK1/2), Bcl-2, and Bax. RESULTS:TBI deteriorated memory function, suppressed neurogenesis, and accelerated apoptosis in the hippocampus. Treadmill exercise and BMSC transplantation independently improved memory function by increasing neurogenesis with suppression of apoptosis through the BDNF-ERK pathway in the TBI-induced rats. Combination of BMSC transplantation with treadmill exercise showed additional enhancement of neurogenesis and suppression of apoptosis in the hippocampus. CONCLUSIONS:The present study shows that treadmill exercise may aid the therapeutic effect of BMSC transplantation on TBI in rats.
journal_name
Int Neurourol Jjournal_title
International neurourology journalauthors
Shin MS,Park HK,Kim TW,Ji ES,Lee JM,Choi HS,Kim MY,Kim YPdoi
10.5213/inj.1632616.308subject
Has Abstractpub_date
2016-05-01 00:00:00pages
S49-56issue
Suppl 1eissn
2093-4777issn
2093-6931pii
inj-1632616-308journal_volume
20pub_type
杂志文章abstract::The neurological coordination of the lower urinary tract can be analyzed from the perspective of motor neurons or sensory neurons. First, sensory nerves with receptors in the bladder and urethra transmits stimuli to the cerebral cortex through the periaqueductal gray (PAG) of the midbrain. Upon the recognition of stim...
journal_title:International neurourology journal
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journal_title:International neurourology journal
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journal_title:International neurourology journal
pub_type: 杂志文章,评审
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journal_title:International neurourology journal
pub_type: 杂志文章
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journal_title:International neurourology journal
pub_type: 已发布勘误
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.3.120
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pub_type: 杂志文章
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journal_title:International neurourology journal
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journal_title:International neurourology journal
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更新日期:2018-07-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.1.34
更新日期:2013-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.2.67
更新日期:2013-06-01 00:00:00
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更新日期:2010-08-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00