Genetic and Epigenetic Alterations in Bladder Cancer.

Abstract:

:Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingly point to distinct genetic and epigenetic alteration patterns in bladder cancer, even between the different stages and grades of disease. In addition, genetic and epigenetic alterations have been demonstrated to play important roles during bladder tumorigenesis. This review will focus on bladder cancer-associated genomic and epigenomic alterations, which are common in bladder cancer and provide potential diagnostic markers and therapeutic targets for bladder cancer treatment.

journal_name

Int Neurourol J

authors

Li HT,Duymich CE,Weisenberger DJ,Liang G

doi

10.5213/inj.1632752.376

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

S84-94

issue

Suppl 2

eissn

2093-4777

issn

2093-6931

pii

inj-1632752-376

journal_volume

20

pub_type

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