Abstract:
:Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology, however it is not fully understood how this neurodegeneration is initiated and what precisely causes this disease. As one aspect of pathophysiology for PD, synaptic dysfunction (synaptopathy) is thought to be an earlier appearance for neurodegeneration. In addition, some of the familial factors cumulatively exhibit that these factors such as α-synuclein, leucine-rich repeat kinase 2, parkin, PTEN-induced kinase 1, and DJ-1 are involved in the regulation of synaptic function and missense mutants of familial factors found in PD-patient show dysregulation of synaptic functions. In this review, we have discussed the physiological function of these genetic factors in presynaptic terminal and how dysregulation of presynaptic function by genetic factors might be related to the pathogenesis of Parkinson disease.
journal_name
Int Neurourol Jjournal_title
International neurourology journalauthors
Lee W,Koh S,Hwang S,Kim SHdoi
10.5213/inj.1836216.108subject
Has Abstractpub_date
2018-10-01 00:00:00pages
S115-121issue
Suppl 3eissn
2093-4777issn
2093-6931pii
inj.1836216.108journal_volume
22pub_type
杂志文章abstract:PURPOSE:To assess the efficacy of the continuous positive airway pressure (CPAP) on nocturia in patients with obstructive sleep apnea (OSA). METHODS:A literature review was performed to identify all published clinical trials of CPAP for the treatment of nocturia. The search included the following databases: MEDLINE, E...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.3.178
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To investigate the clinical factors associated with the feeling of incomplete bladder emptying in female patients with lower urinary tract symptoms (LUTS). METHODS:Records were obtained from a prospectively maintained database for 353 female patients without a history of treatment for LUTS. Patients with comor...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938256.128
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To review the clinical outcomes of patients with voiding dysfunction who have detrusor overactivity with impaired contractility (DOIC) diagnosed with urodynamic studies. METHODS:Urodynamic reports from 2005 to 2009 were reviewed, and 54 male patients had findings consistent with DOIC. Patients with acontractil...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.3.133
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:The purpose of this study was to review studies that have examined the quality of life of women with urinary incontinence. MATERIALS AND METHODS:A review was conducted that used the databases PubMED, Proquest, CINAHL, and Sciencedirect. Articles were included that were published in English between 2005 and 201...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.3.133
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To evaluate the effects of botulinum toxin on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity. METHODS:Thirty four adult patients with spinal cord injury and detrusor overactivity were selected. The patients received 300 units of botulinum toxin type A. The endpoints...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.3.139
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Bladder wall thickness has been reported to be associated with overactive bladder (OAB) in women. Diabetic women have an increased risk for OAB syndrome and may have an increased risk for bladder wall thickness. METHODS:A total of 235 female patients aged 40 to 75 years were categorized into four groups. The f...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.2.67
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:We investigated bladder function, with a special focus on nonvoiding contractions (NVCs), in awake rats with chronic chemical cystitis and bladder outlet obstruction (BOO) by use of simultaneous registrations of intravesical and intraabdominal pressures. In addition, we tested the effects of tolterodine on the ...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.3.120
更新日期:2011-09-01 00:00:00
abstract::In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance. The purpose of this review is to summarize the current state of knowledge about mechanisms and potential appli...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.203
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction, or urinary incontinence due to pelvic muscle weakness induced by aging. Physical exercise has been recomme...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.2.77
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Lower urinary tract dysfunction is the most common complication after radical pelvic surgery. The aims of this study were to assess the effect of radical hysterectomy (RH) on the storage function of the lower urinary tract and to evaluate the impact of radiation therapy (RT) on postoperative urodynamic paramete...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.2.91
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:Sacral nerve stimulation has been used to treat overactive bladder. This study evaluated the effects of stimulation using different pulse widths on the inhibition of bladder overactivity by sacral nerve stimulation (SNM) in pigs. METHODS:Implant-driven stimulators were used to stimulate the S3 spinal nerve in ...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938042.021
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To evaluate whether hydrodistention with fulguration of Hunner lesions (HD/FUL) plus maintenance dimethyl sulfoxide (DMSO) therapy prolongs the recurrence-free time in patients with Hunner type interstitial cystitis (IC). METHODS:The study enrolled patients with Hunner type IC who required repeat HD/FUL due to...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938110.055
更新日期:2019-12-01 00:00:00
abstract::The clinical success of mirabegron as the first β3-adrenoceptor (AR) agonist for treatment of the overactive bladder (OAB) syndrome, has resulted in substantial interest in its site and mechanism of action. Even if the adrenergic innervation of the bladder and urethra has been well studied, the location(s) of β3-ARs i...
journal_title:International neurourology journal
pub_type: 杂志文章,评审
doi:10.5213/inj.1734850.425
更新日期:2017-03-24 00:00:00
abstract:PURPOSE:We aimed to evaluate obesity, a risk factor of metabolic syndrome, and its association with prostatic enlargement in a retrospective cohort in Korea. METHODS:Baseline data were obtained from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1632584.292
更新日期:2016-12-01 00:00:00
abstract::A noncontact mapping system (EnSite) was used for electroanatomical mapping of the bladder simultaneously with pressure flow study in three women with lower urinary tract symptoms. We selected the periods of obvious detrusor activity. Data were processed to remove baseline drift, and an envelope of electrovesicography...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1630504.252
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:This study was performed to characterise the nature, clinical presentation, mode of insertion, and management of intravesical foreign bodies in patients treated at our hospital. METHODS:Between January 2008 and December 2014, 49 patients were treated for intravesical foreign bodies at King George Medical Unive...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1632524.262
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:We aimed to assess whether nerve-sparing radical prostatectomy (nsRP) is associated with improved recovery of urinary continence compared to non-nerve-sparing radical prostatectomy (nnsRP) in patients with localized prostate cancer and preoperative erectile dysfunction. METHODS:A total of 360 patients with org...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1630428.214
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Recently, reports in the mass media have implicated that bicycle riding increases the risk of erectile dysfunction and prostatic diseases. So, we evaluate the impact of bicycle riding on erectile function and lower urinary tract symptoms (LUTS) in healthy general men. METHODS:From 26 June 2010 to 20 July 2010,...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.2.97
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:Benign prostatic hyperplasia is often accompanied by age-related comorbidity, such as erectile dysfunction (ED). Recent data suggest an association between ED and lower urinary tract symptoms (LUTS), and increasing evidence indicates that the clinical use of phosphodiesterase type 5 (PDE5) inhibitors provides r...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.1.7
更新日期:2010-04-01 00:00:00
abstract::This review assessed the epidemiology of voiding dysfunctions in South Korea. Comprehensive understanding of this epidemiology is crucial because the senior population and the social burden are increasing because of voiding dysfunctions is growing. We searched the medical records using several terms related to voiding...
journal_title:International neurourology journal
pub_type: 杂志文章,评审
doi:10.5213/inj.1630502.251
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:We studied the influence of preoperative bladder outlet obstruction (BOO) on postoperative continence rates and patient satisfaction after the midurethral sling procedure. METHODS:A total of 159 women who underwent the midurethral sling procedure were evaluated. Using the Blaivas-Groutz nomogram, we assigned t...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.267
更新日期:2010-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.2.107
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of an alpha-1 adrenergic receptor (α1-AR) blocker for the treatment of female voiding dysfunction (FVD) through a pressure-flow study. METHODS:This was a randomized, double-blind, placebo-controlled trial. Women aged ≥18 years with voiding symptoms, as defined by an American Urological...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1834904.452
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Ketamine may decrease core-to-peripheral redistribution of heat through direct central sympathetic stimulation and inhibition of norepinephrine uptake into postganglionic sympathetic nerve endings. The purpose of this study was to evaluate the efficacy of epidural ketamine in preventing shivering during transur...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.2.105
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:As the elderly population increases, a growing number of patients have lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH). The aim of this study was to develop decision support formulas and nomograms for the prediction of bladder outlet obstruction (BOO) and for BOO-related surgical decision-...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1734852.426
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:Maintaining urinary continence at stress requires a competent urethral sphincter and good suburethral support. Sphincter competence is estimated by measuring the maximal urethral closure pressure at rest. We aimed to study the value of a new urodynamic measure, the urethral closure pressure at stress (s-UCP), i...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1732686.343
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:This study reports the development of the Korean Version of the Treatment Satisfaction Visual Analogue Scale (TS-VAS) and the Overactive Bladder Satisfaction with Treatment Questionnaire (OAB-SAT-q) based on the original versions, with subsequent linguistic validation by Korean patients with overactive bladder ...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1734992.496
更新日期:2017-12-01 00:00:00
abstract:Purpose:This study aimed to evaluate the accuracy and reliability of a new smartphone-based acoustic uroflowmetry compared to conventional uroflowmetry. Methods:This was a prospective validation study enrolling 128 subjects from September 2017 to April 2018 comparing a novel acoustic uroflowmetry to conventional urofl...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2040250.125
更新日期:2021-01-04 00:00:00
abstract::The apical surface of mammalian urinary epithelium is covered by numerous scallop-shaped membrane plaques. This plaque consists of four different uroplakins (UPs) and integral membrane proteins. UPs, which are a member of the tetraspanin superfamily, are assembled into plaques that act as an exceptional barrier to wat...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.1.4
更新日期:2011-03-01 00:00:00
abstract::Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingly point to distinct...
journal_title:International neurourology journal
pub_type: 杂志文章,评审
doi:10.5213/inj.1632752.376
更新日期:2016-11-01 00:00:00