Presynaptic Dysfunction by Familial Factors in Parkinson Disease.

Abstract:

:Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology, however it is not fully understood how this neurodegeneration is initiated and what precisely causes this disease. As one aspect of pathophysiology for PD, synaptic dysfunction (synaptopathy) is thought to be an earlier appearance for neurodegeneration. In addition, some of the familial factors cumulatively exhibit that these factors such as α-synuclein, leucine-rich repeat kinase 2, parkin, PTEN-induced kinase 1, and DJ-1 are involved in the regulation of synaptic function and missense mutants of familial factors found in PD-patient show dysregulation of synaptic functions. In this review, we have discussed the physiological function of these genetic factors in presynaptic terminal and how dysregulation of presynaptic function by genetic factors might be related to the pathogenesis of Parkinson disease.

journal_name

Int Neurourol J

authors

Lee W,Koh S,Hwang S,Kim SH

doi

10.5213/inj.1836216.108

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

S115-121

issue

Suppl 3

eissn

2093-4777

issn

2093-6931

pii

inj.1836216.108

journal_volume

22

pub_type

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