Abstract:
PURPOSE:Benign prostatic hyperplasia is often accompanied by age-related comorbidity, such as erectile dysfunction (ED). Recent data suggest an association between ED and lower urinary tract symptoms (LUTS), and increasing evidence indicates that the clinical use of phosphodiesterase type 5 (PDE5) inhibitors provides relief from LUTS. The aim of the present study was to investigate the effects of tadalafil (20 mg once every 3 days for 12 weeks, p.o.) in men with moderate-to-severe ED and LUTS and to investigate the duration of the effects of tadalafil beyond treatment cessation. MATERIALS AND METHODS:Men with an International Index of Erectile Function-5 (IIEF-5) score of less than 11 (representing "moderate-to-severe" ED status) and with an International Prostate Symptom Score (IPSS) of more than 8 (representing "moderate-to-severe" LUTS status) were enrolled. IPSS (total score, storage subscore, and voiding subscore) and IIEF-5 scores before treatment (baseline), during treatment (weeks 4 and 12 after treatment commencement), and after treatment (weeks 16 and 20after treatment commencement) were compared. RESULTS:IPSS and IIEF-5 scores were significantly different between baseline and week 12 after treatment commencement. Furthermore, these scores were significantly different between baseline and week 20 after treatment commencement. However, except for IIEF-5 scores, no significant differences were observed between week 12 and week 20. CONCLUSIONS:Treatment with 20 mg tadalafil (once every 3 days) had beneficial effects on LUTS and ED beyond treatment cessation in patients with moderate-to-severe ED and LUTS.
journal_name
Int Neurourol Jjournal_title
International neurourology journalauthors
Kim TB,Kim KH,Yoon SJdoi
10.5213/inj.2010.14.1.7subject
Has Abstractpub_date
2010-04-01 00:00:00pages
7-12issue
1eissn
2093-4777issn
2093-6931journal_volume
14pub_type
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.2.97
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.2.67
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.203
更新日期:2010-12-01 00:00:00
abstract::[This corrects the article on p. 164 in vol. 14, PMID: 21179334.]. ...
journal_title:International neurourology journal
pub_type: 杂志文章,已发布勘误
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更新日期:2011-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1632584.292
更新日期:2016-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.2.91
更新日期:2012-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.267
更新日期:2010-12-01 00:00:00
abstract::Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology, however it is not fully understood how this neurodegeneration is initiated and what precisely causes this disease. As...
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pub_type: 杂志文章
doi:10.5213/inj.1836216.108
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pub_type: 杂志文章
doi:10.5213/inj.1836124.062
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.2.107
更新日期:2015-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.2.105
更新日期:2010-08-01 00:00:00
abstract::This review assessed the epidemiology of voiding dysfunctions in South Korea. Comprehensive understanding of this epidemiology is crucial because the senior population and the social burden are increasing because of voiding dysfunctions is growing. We searched the medical records using several terms related to voiding...
journal_title:International neurourology journal
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1630504.252
更新日期:2016-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.3.133
更新日期:2010-10-01 00:00:00
abstract::Lower urinary tract symptoms (LUTS) are a cluster of voiding symptoms, such as weak stream, hesitancy, intermittency, urinary frequency, urgency, and nocturia. LUTS are frequent in elderly men and it considered the ultimate clinical symptoms of benign prostatic hyperplasia. With aging, male hypogonadism is increased w...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2040234.117
更新日期:2021-01-19 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00