Abstract:
PURPOSE:The neurological molecular mechanisms underlying the voiding dysfunction associated with nonbacterial chronic prostatitis/chronic pelvic pain syndrome remain poorly understood. In this study, we assessed whether prostate inflammation activated bladder afferent neurons, leading to bladder dysfunction, and sought to elucidate the underlying mechanisms. METHODS:Thirty male Sprague-Dawley rats were divided into 3 groups: sham-saline, formalin-injected, and capsaicin-pretreated and formalin-injected. Chemical prostatitis was induced by 0.1 mL of 10% buffered formalin injected into the ventral prostate. Capsaicin was injected subcutaneously to desensitize capsaicin-sensitive nerves. In each group, conscious cystometry was performed, and c-fos expression within the spinal cord was determined immunocytochemically. Double immunofluorescent staining with c-fos and choline acetyltransferase (ChAT) was performed. On the third day after pseudorabies virus (PRV) infection, c-fos and PRV double-staining was performed. RESULTS:Intraprostatic formalin significantly increased the maximal voiding pressure and decreased the intercontraction interval, compared with controls. Pretreatment with capsaicin significantly reversed these effects. More c-fos-positive cells were observed in the sacral parasympathetic nucleus (SPN) and dorsal gray commissure (DCM) in the prostatitis group than in the sham group. c-fos-positive cells decreased in the capsaicin-pretreated group. Preganglionic neurons labeled by c-fos and ChAT were observed in the SPN in rats with prostatitis. Interneurons labeled by c-fos and PRV were identified in the DCM after PRV infection. Conclusions:Our results suggest that prostate inflammation activates afferent nerve fibers projecting to the lumbosacral spinal cord, producing reflex activation of spinal neurons innervating the bladder and bladder hyperreflexia. This is mediated by capsaicin-sensitive prostate afferent neurons.
journal_name
Int Neurourol Jjournal_title
International neurourology journalauthors
Park JS,Jin MH,Hong CHdoi
10.5213/inj.1836124.062subject
Has Abstractpub_date
2018-06-01 00:00:00pages
90-98issue
2eissn
2093-4777issn
2093-6931pii
inj.1836124.062journal_volume
22pub_type
杂志文章abstract:PURPOSE:Lower urinary tract dysfunction is the most common complication after radical pelvic surgery. The aims of this study were to assess the effect of radical hysterectomy (RH) on the storage function of the lower urinary tract and to evaluate the impact of radiation therapy (RT) on postoperative urodynamic paramete...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.2.91
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journal_title:International neurourology journal
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journal_title:International neurourology journal
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.203
更新日期:2010-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.267
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journal_title:International neurourology journal
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doi:10.5213/inj.2012.16.3.139
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.3.133
更新日期:2010-10-01 00:00:00
abstract::Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology, however it is not fully understood how this neurodegeneration is initiated and what precisely causes this disease. As...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1836216.108
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journal_title:International neurourology journal
pub_type: 杂志文章
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journal_title:International neurourology journal
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1734824.412
更新日期:2017-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.1.4
更新日期:2011-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938110.055
更新日期:2019-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2040250.125
更新日期:2021-01-04 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1834904.452
更新日期:2018-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.3.133
更新日期:2014-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.3.178
更新日期:2015-09-01 00:00:00
abstract::[This corrects the article on p. 164 in vol. 14, PMID: 21179334.]. ...
journal_title:International neurourology journal
pub_type: 杂志文章,已发布勘误
doi:10.5213/inj.2011.15.3.181
更新日期:2011-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章,评审
doi:10.5213/inj.1734850.425
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.1.34
更新日期:2013-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1836174.087
更新日期:2018-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.2.67
更新日期:2013-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938042.021
更新日期:2019-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1732686.343
更新日期:2017-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1632616.308
更新日期:2016-05-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.2.107
更新日期:2015-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1630504.252
更新日期:2016-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.4.221
更新日期:2014-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.2.77
更新日期:2014-06-01 00:00:00