Abstract:
PURPOSE:The neurological molecular mechanisms underlying the voiding dysfunction associated with nonbacterial chronic prostatitis/chronic pelvic pain syndrome remain poorly understood. In this study, we assessed whether prostate inflammation activated bladder afferent neurons, leading to bladder dysfunction, and sought to elucidate the underlying mechanisms. METHODS:Thirty male Sprague-Dawley rats were divided into 3 groups: sham-saline, formalin-injected, and capsaicin-pretreated and formalin-injected. Chemical prostatitis was induced by 0.1 mL of 10% buffered formalin injected into the ventral prostate. Capsaicin was injected subcutaneously to desensitize capsaicin-sensitive nerves. In each group, conscious cystometry was performed, and c-fos expression within the spinal cord was determined immunocytochemically. Double immunofluorescent staining with c-fos and choline acetyltransferase (ChAT) was performed. On the third day after pseudorabies virus (PRV) infection, c-fos and PRV double-staining was performed. RESULTS:Intraprostatic formalin significantly increased the maximal voiding pressure and decreased the intercontraction interval, compared with controls. Pretreatment with capsaicin significantly reversed these effects. More c-fos-positive cells were observed in the sacral parasympathetic nucleus (SPN) and dorsal gray commissure (DCM) in the prostatitis group than in the sham group. c-fos-positive cells decreased in the capsaicin-pretreated group. Preganglionic neurons labeled by c-fos and ChAT were observed in the SPN in rats with prostatitis. Interneurons labeled by c-fos and PRV were identified in the DCM after PRV infection. Conclusions:Our results suggest that prostate inflammation activates afferent nerve fibers projecting to the lumbosacral spinal cord, producing reflex activation of spinal neurons innervating the bladder and bladder hyperreflexia. This is mediated by capsaicin-sensitive prostate afferent neurons.
journal_name
Int Neurourol Jjournal_title
International neurourology journalauthors
Park JS,Jin MH,Hong CHdoi
10.5213/inj.1836124.062subject
Has Abstractpub_date
2018-06-01 00:00:00pages
90-98issue
2eissn
2093-4777issn
2093-6931pii
inj.1836124.062journal_volume
22pub_type
杂志文章abstract:PURPOSE:To assess the efficacy of the continuous positive airway pressure (CPAP) on nocturia in patients with obstructive sleep apnea (OSA). METHODS:A literature review was performed to identify all published clinical trials of CPAP for the treatment of nocturia. The search included the following databases: MEDLINE, E...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.3.178
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To review the clinical outcomes of patients with voiding dysfunction who have detrusor overactivity with impaired contractility (DOIC) diagnosed with urodynamic studies. METHODS:Urodynamic reports from 2005 to 2009 were reviewed, and 54 male patients had findings consistent with DOIC. Patients with acontractil...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.3.133
更新日期:2014-09-01 00:00:00
abstract::Lower urinary tract symptoms (LUTS) are a cluster of voiding symptoms, such as weak stream, hesitancy, intermittency, urinary frequency, urgency, and nocturia. LUTS are frequent in elderly men and it considered the ultimate clinical symptoms of benign prostatic hyperplasia. With aging, male hypogonadism is increased w...
journal_title:International neurourology journal
pub_type: 杂志文章
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更新日期:2021-01-19 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.1.39
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:We aimed to evaluate obesity, a risk factor of metabolic syndrome, and its association with prostatic enlargement in a retrospective cohort in Korea. METHODS:Baseline data were obtained from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1632584.292
更新日期:2016-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.2.91
更新日期:2012-06-01 00:00:00
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journal_title:International neurourology journal
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1632524.262
更新日期:2016-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.4.259
更新日期:2015-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1836152.076
更新日期:2018-07-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.4.203
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:To find the association of trial without catheter (TWOC) outcome for first spontaneous acute urinary retention (AUR) in benign prostatic obstruction with age, prior lower urinary tract symptoms (LUTS), retention volume at catheterization (RV), and size of prostate. METHODS:Our prospective observational analyti...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.3.121
更新日期:2013-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1836174.087
更新日期:2018-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938042.021
更新日期:2019-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1734992.496
更新日期:2017-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.2.105
更新日期:2010-08-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.4.221
更新日期:2014-12-01 00:00:00
abstract::Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology, however it is not fully understood how this neurodegeneration is initiated and what precisely causes this disease. As...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1836216.108
更新日期:2018-10-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1632616.308
更新日期:2016-05-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938110.055
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.2.77
更新日期:2014-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1630504.252
更新日期:2016-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 已发布勘误
doi:10.5213/inj.1620err.002
更新日期:2016-12-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.1.23
更新日期:2012-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1734824.412
更新日期:2017-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.1.7
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To evaluate the effects of botulinum toxin on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity. METHODS:Thirty four adult patients with spinal cord injury and detrusor overactivity were selected. The patients received 300 units of botulinum toxin type A. The endpoints...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2012.16.3.139
更新日期:2012-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章,评审
doi:10.5213/inj.1734850.425
更新日期:2017-03-24 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.3.120
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:Bladder wall thickness has been reported to be associated with overactive bladder (OAB) in women. Diabetic women have an increased risk for OAB syndrome and may have an increased risk for bladder wall thickness. METHODS:A total of 235 female patients aged 40 to 75 years were categorized into four groups. The f...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.2.67
更新日期:2013-06-01 00:00:00