Abstract:
PURPOSE:As the elderly population increases, a growing number of patients have lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH). The aim of this study was to develop decision support formulas and nomograms for the prediction of bladder outlet obstruction (BOO) and for BOO-related surgical decision-making, and to validate them in patients with LUTS/BPH. METHODS:Patient with LUTS/BPH between October 2004 and May 2014 were enrolled as a development cohort. The available variables included age, International Prostate Symptom Score, free uroflowmetry, postvoid residual volume, total prostate volume, and the results of a pressure-flow study. A causal Bayesian network analysis was used to identify relevant parameters. Using multivariate logistic regression analysis, formulas were developed to calculate the probabilities of having BOO and requiring prostatic surgery. Patients between June 2014 and December 2015 were prospectively enrolled for internal validation. Receiver operating characteristic curve analysis, calibration plots, and decision curve analysis were performed. RESULTS:A total of 1,179 male patients with LUTS/BPH, with a mean age of 66.1 years, were included as a development cohort. Another 253 patients were enrolled as an internal validation cohort. Using multivariate logistic regression analysis, 2 and 4 formulas were established to estimate the probabilities of having BOO and requiring prostatic surgery, respectively. Our analysis of the predictive accuracy of the model revealed area under the curve values of 0.82 for BOO and 0.87 for prostatic surgery. The sensitivity and specificity were 53.6% and 87.0% for BOO, and 91.6% and 50.0% for prostatic surgery, respectively. The calibration plot indicated that these prediction models showed a good correspondence. In addition, the decision curve analysis showed a high net benefit across the entire spectrum of probability thresholds. CONCLUSIONS:We established nomograms for the prediction of BOO and BOO-related prostatic surgery in patients with LUTS/BPH. Internal validation of the nomograms demonstrated that they predicted both having BOO and requiring prostatic surgery very well.
journal_name
Int Neurourol Jjournal_title
International neurourology journalauthors
Choo MS,Yoo C,Cho SY,Jeong SJ,Jeong CW,Ku JH,Oh SJdoi
10.5213/inj.1734852.426subject
Has Abstractpub_date
2017-04-01 00:00:00pages
S55-65issue
Suppl 1eissn
2093-4777issn
2093-6931pii
inj-1734852-426journal_volume
21pub_type
杂志文章abstract:PURPOSE:Benign prostatic hyperplasia is often accompanied by age-related comorbidity, such as erectile dysfunction (ED). Recent data suggest an association between ED and lower urinary tract symptoms (LUTS), and increasing evidence indicates that the clinical use of phosphodiesterase type 5 (PDE5) inhibitors provides r...
journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2010.14.1.7
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journal_title:International neurourology journal
pub_type: 杂志文章
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journal_title:International neurourology journal
pub_type: 杂志文章,评审
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journal_title:International neurourology journal
pub_type: 杂志文章
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journal_title:International neurourology journal
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International neurourology journal
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.5213/inj.1734824.412
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pub_type: 杂志文章
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.3.178
更新日期:2015-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1630504.252
更新日期:2016-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2011.15.3.120
更新日期:2011-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938042.021
更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-04 00:00:00
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journal_title:International neurourology journal
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journal_title:International neurourology journal
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journal_title:International neurourology journal
pub_type: 已发布勘误
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更新日期:2016-05-01 00:00:00
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更新日期:2010-08-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1834904.452
更新日期:2018-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2013.17.1.34
更新日期:2013-03-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.1938256.128
更新日期:2020-06-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2015.19.1.39
更新日期:2015-03-01 00:00:00
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更新日期:2018-09-01 00:00:00
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journal_title:International neurourology journal
pub_type: 杂志文章
doi:10.5213/inj.2014.18.4.221
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journal_title:International neurourology journal
pub_type: 杂志文章,评审
doi:10.5213/inj.1734850.425
更新日期:2017-03-24 00:00:00