Inulin-D-α-tocopherol succinate (INVITE) nanomicelles as a platform for effective intravenous administration of curcumin.

Abstract:

:The aim of this work was to evaluate the potential of INVITE-based nanomicelles, an amphiphilic polymer constituted by inulin (INU) and vitamin E (VITE), as a platform for improving the biopharmaceutical properties of hydrophobic drugs. For this purpose, curcumin was selected as a model and curcumin-INVITE nanomicelles were prepared. This drug delivery system was characterized both in vitro for what concerns the physicochemical properties, blood compatibility, and cellular uptake, and in vivo for the evaluation of the pharmacokinetic profile. It was found that these nanomicelles released curcumin in a controlled manner, and they were able to penetrate cellular membrane. Moreover, they showed an improved pharmacokinetic profile after intravenous administration. In conclusion, INVITE micelles might constitute promising nanocarriers for improving the biopharmaceutical performance of hydrophobic drugs.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Tripodo G,Pasut G,Trapani A,Mero A,Lasorsa FM,Chlapanidas T,Trapani G,Mandracchia D

doi

10.1021/bm501616e

subject

Has Abstract

pub_date

2015-02-09 00:00:00

pages

550-7

issue

2

eissn

1525-7797

issn

1526-4602

journal_volume

16

pub_type

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