Abstract:
:The aim of this work was to evaluate the potential of INVITE-based nanomicelles, an amphiphilic polymer constituted by inulin (INU) and vitamin E (VITE), as a platform for improving the biopharmaceutical properties of hydrophobic drugs. For this purpose, curcumin was selected as a model and curcumin-INVITE nanomicelles were prepared. This drug delivery system was characterized both in vitro for what concerns the physicochemical properties, blood compatibility, and cellular uptake, and in vivo for the evaluation of the pharmacokinetic profile. It was found that these nanomicelles released curcumin in a controlled manner, and they were able to penetrate cellular membrane. Moreover, they showed an improved pharmacokinetic profile after intravenous administration. In conclusion, INVITE micelles might constitute promising nanocarriers for improving the biopharmaceutical performance of hydrophobic drugs.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Tripodo G,Pasut G,Trapani A,Mero A,Lasorsa FM,Chlapanidas T,Trapani G,Mandracchia Ddoi
10.1021/bm501616esubject
Has Abstractpub_date
2015-02-09 00:00:00pages
550-7issue
2eissn
1525-7797issn
1526-4602journal_volume
16pub_type
杂志文章abstract::The drying dynamics of protein coatings is of importance for many applications. The main focus of research so far was to investigate macroscopic properties of protein coatings, leaving drying dynamics virtually unexplored. A unique combination of techniques is used to monitor drying of a coating containing the protein...
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