Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels.

abstract：:The density of corn pollen on leaves of milkweed plants inside and outside of cornfields was measured in several studies from different localities. The purpose was to obtain a representative picture of naturally occurring pollen densities to provide a perspective for laboratory and field studies of monarch larvae feed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pleasants JM,Hellmich RL,Dively GP,Sears MK,Stanley-Horn DE,Mattila HR,Foster JE,Clark P,Jones GD

更新日期：2001-10-09 00:00:00

abstract：:A discrepancy of about 20% exists between the molecular weight of the alpha subunit of Torpedo californica electroplax acetylcholine receptor as determined by gel electrophoresis of the mature protein (Mr 40,000 +/- 2000) and by nucleotide sequence analysis of cDNA (Mr approximately equal to 50,000). We demonstrate by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conti-Tronconi BM,Hunkapiller MW,Raftery MA

更新日期：1984-05-01 00:00:00

abstract：:Proteins have evolved to be foldable, and yet determinants of foldability may be inapparent once the native state is reached. Insight has emerged from studies of diseases of protein misfolding, exemplified by monogenic diabetes mellitus due to mutations in proinsulin leading to endoplasmic reticulum stress and β-cell ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rege NK,Liu M,Yang Y,Dhayalan B,Wickramasinghe NP,Chen YS,Rahimi L,Guo H,Haataja L,Sun J,Ismail-Beigi F,Phillips NB,Arvan P,Weiss MA

更新日期：2020-11-24 00:00:00

abstract：:Karrikins are a class of seed germination stimulants identified in smoke from wildfires. Microarray analysis of imbibed Arabidopsis thaliana seeds was performed to identify transcriptional responses to KAR(1) before germination. A small set of genes that are regulated by KAR(1), even when germination is prevented by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson DC,Flematti GR,Riseborough JA,Ghisalberti EL,Dixon KW,Smith SM

更新日期：2010-04-13 00:00:00

abstract：:When rat pancreatic polynucleosomes were poly(ADP-ribosyl)ated with purified calf thymus poly(ADP-ribose) polymerase and examined by electron microscopy, a relaxation of their native zigzag structure was observed. At high ionic strengths control nucleosomes condensed into 250-A-thick fibers, but poly(ADP-ribosyl)ated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poirier GG,de Murcia G,Jongstra-Bilen J,Niedergang C,Mandel P

更新日期：1982-06-01 00:00:00

abstract：:Escherichia coli phage N4 transcription is resistant to rifampicin, an inhibitor of the host RNA polymerase, even when the drug is added prior to infection. A rifampicin-resistant RNA polymerase has been detected in disrupted N4 virions. This enzyme shows a requirement for the four ribonucleoside 5'-triphosphates and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falco SC,Laan KV,Rothman-Denes LB

更新日期：1977-02-01 00:00:00

abstract：:A specific lipoprotein of the E. coli outer membrane has been synthesized in a cell-free system directed by purified messenger RNA. The mRNA for the lipoprotein was purified as 7S RNA about 250-fold from exponentially growing cells. Protein synthesis of the cell-free system was totally dependent upon the addition of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirashima A,Wang S,Inouye M

更新日期：1974-10-01 00:00:00

abstract：:Plants, as sessile organisms, must coordinate various physiological processes to adapt to ever-changing surrounding environments. Stomata, the epidermal pores facilitating gas and water exchange, play important roles in optimizing photosynthetic efficiency and adaptability. Stomatal development is under the control of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang JY,He SB,Li L,Yang HQ

更新日期：2014-07-22 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:Double-stranded RNA (dsRNA) recently has been shown to give rise to genetic interference in Caenorhabditis elegans and also is likely to be the basis for phenotypic cosuppression in plants in certain instances. While constructing a plasmid vector for transfection of trypanosome cells, we serendipitously discovered tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ngô H,Tschudi C,Gull K,Ullu E

更新日期：1998-12-08 00:00:00

abstract：:The clinical efficacy of local anesthetic and antiarrhythmic drugs is due to their voltage- and frequency-dependent block of Na+ channels. Quaternary local anesthetic analogs such as QX-314, which are permanently charged and membrane-impermeant, effectively block cardiac Na+ channels when applied from either side of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qu Y,Rogers J,Tanada T,Scheuer T,Catterall WA

更新日期：1995-12-05 00:00:00

abstract：:Retrieval of recently acquired declarative memories depends on the hippocampus, but with time, retrieval is increasingly sustainable by neocortical representations alone. This process has been conceptualized as system-level consolidation. Using functional magnetic resonance imaging, we assessed over the course of thre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takashima A,Petersson KM,Rutters F,Tendolkar I,Jensen O,Zwarts MJ,McNaughton BL,Fernández G

更新日期：2006-01-17 00:00:00

abstract：:The recombinant plasmid p102 based on pBR322 carrying approximately equal to 50% of the replicator proximal early region of simian virus 40 (SV40) DNA, including the viral origin of replication, has been constructed. It lacks a major part of the large tumor (T) antigen 3'-coding region, the T-antigen termination codon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horst J,Weckler C,Jacob E,Aulehla-Scholz C,Deppert W

更新日期：1982-08-01 00:00:00

abstract：:The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manella G,Aviram R,Bolshette N,Muvkadi S,Golik M,Smith DF,Asher G

更新日期：2020-01-07 00:00:00

abstract：:Although the role of liganded nuclear receptors in mediating coactivator/corepressor exchange is well-established, little is known about the potential regulation of chromosomal organization in the 3-dimensional space of the nucleus in achieving integrated transcriptional responses to diverse signaling events. Here, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Q,Kwon YS,Nunez E,Cardamone MD,Hutt KR,Ohgi KA,Garcia-Bassets I,Rose DW,Glass CK,Rosenfeld MG,Fu XD

更新日期：2008-12-09 00:00:00

abstract：:Light-grown, wild type Euglena gracilis contains two aminoacyl-tRNA synthetases for both phenylalanine and isoleucine. Only one of the two synthetases for each amino acid is found in isolated chloroplasts, as are the light-induced phenylalanine and isoleucine tRNAs. In each case the light-induced chloroplast tRNAs can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reger BJ,Fairfield SA,Epler JL,Barnett WE

更新日期：1970-11-01 00:00:00

abstract：:The CH family of murine B-cell lymphomas includes several members that are sensitive to growth inhibition when their membrane IgM (mIgM) receptors are cross-linked by anti-mu chain, anti-kappa chain, or anti-idiotypic antibodies. These lymphomas are IgM+, Ia+, and IgD +/- and resemble neonatal B cells in terms of thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alés-Martínez JE,Warner GL,Scott DW

更新日期：1988-09-01 00:00:00

abstract：:The Drosophila clock genes period (per) and timeless (tim) have been studied behaviorally and biochemically, but to date there has been no viable culture system for studying the cell biology of the Drosophila clock. We have cultured pupal ring glands attached to the central nervous system and observed rhythms of perio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emery IF,Noveral JM,Jamison CF,Siwicki KK

更新日期：1997-04-15 00:00:00

abstract：:Wild and managed bees are well documented as effective pollinators of global crops of economic importance. However, the contributions by pollinators other than bees have been little explored despite their potential to contribute to crop production and stability in the face of environmental change. Non-bee pollinators ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rader R,Bartomeus I,Garibaldi LA,Garratt MP,Howlett BG,Winfree R,Cunningham SA,Mayfield MM,Arthur AD,Andersson GK,Bommarco R,Brittain C,Carvalheiro LG,Chacoff NP,Entling MH,Foully B,Freitas BM,Gemmill-Herren B,Ghazoul

更新日期：2016-01-05 00:00:00

abstract：:A general model is proposed for genetic recombination. Its essential new feature is the hypothesis that recombination is initiated by a single-strand (or asymmetric) transfer, which may, after isomerization, become a two-strand (or symmetric) exchange. The likelihood of this transition from asymmetric to symmetric str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meselson MS,Radding CM

更新日期：1975-01-01 00:00:00

abstract：:Microorganisms must sense their environment and rapidly tune their metabolism to ambient conditions to efficiently use available resources. We have identified a gene encoding a response regulator, NblR, that complements a cyanobacterial mutant unable to degrade its light-harvesting complex (phycobilisome), in response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwarz R,Grossman AR

更新日期：1998-09-01 00:00:00

abstract：:In the mammalian testis, the blood-testis barrier (BTB), unlike the blood-brain and blood-retina barriers, is composed of coexisting tight junctions (TJs) and adherens junctions (AJs). Yet these junctions must open (or disassemble) to accommodate the migration of preleptotene and leptotene spermatocytes across the BTB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan HH,Cheng CY

更新日期：2005-08-16 00:00:00

abstract：:Lizards and snakes putatively arose between the early Jurassic and late Triassic; they diversified worldwide and now occupy many different ecological niches, making them ideal for testing theories on the origin of ecological traits. We propose and test the "deep history hypothesis," which claims that differences in ec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vitt LJ,Pianka ER

更新日期：2005-05-31 00:00:00

abstract：:The protein CopC from Pseudomonas syringae has been found capable of binding copper(I) and copper(II) at two different sites, occupied either one at a time or simultaneously. The protein, consisting of 102 amino acids, is known to bind copper(II) in a position that is now found consistent with a coordination arrangeme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnesano F,Banci L,Bertini I,Mangani S,Thompsett AR

更新日期：2003-04-01 00:00:00

abstract：:We provide evidence that citrate anions bridge between mineral platelets in bone and hypothesize that their presence acts to maintain separate platelets with disordered regions between them rather than gradual transformations into larger, more ordered blocks of mineral. To assess this hypothesis, we take as a model fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davies E,Müller KH,Wong WC,Pickard CJ,Reid DG,Skepper JN,Duer MJ

更新日期：2014-04-08 00:00:00

abstract：:Nanoparticle-based experimental therapeutics are currently being investigated in numerous human clinical trials. CALAA-01 is a targeted, polymer-based nanoparticle containing small interfering RNA (siRNA) and, to our knowledge, was the first RNA interference (RNAi)-based, experimental therapeutic to be administered to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuckerman JE,Gritli I,Tolcher A,Heidel JD,Lim D,Morgan R,Chmielowski B,Ribas A,Davis ME,Yen Y

更新日期：2014-08-05 00:00:00

abstract：:Store-operated Ca(2+) entry depends critically on physical interactions of the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) and the Ca(2+) release-activated Ca(2+) (CRAC) channel protein Orai1. Recent studies support a diffusion-trap mechanism in which ER Ca(2+) depletion causes STIM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoover PJ,Lewis RS

更新日期：2011-08-09 00:00:00

abstract：:Although it is now more than two decades since it was first reported that the imidazobenzodiazepine Ro15-4513 reverses behavioral alcohol effects, the molecular target(s) of Ro15-4513 and the mechanism of alcohol antagonism remain elusive. Here, we show that Ro15-4513 blocks the alcohol enhancement on recombinant "ext...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallner M,Hanchar HJ,Olsen RW

更新日期：2006-05-30 00:00:00

abstract：:We investigated the participation of genomic regulatory events in the response of the songbird brain to a natural auditory stimulus of known physiological and behavioral relevance, birdsong. Using in situ hybridization, we detected a rapid increase in forebrain mRNA levels of an immediate-early gene encoding a transcr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mello CV,Vicario DS,Clayton DF

更新日期：1992-08-01 00:00:00

abstract：:Global climate change is expected to have broad ecological consequences for species and communities. Attempts to forecast these consequences usually assume that changes in air or water temperature will translate into equivalent changes in a species' organismal body temperature. This simple change is unlikely because a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilman SE,Wethey DS,Helmuth B

更新日期：2006-06-20 00:00:00