Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.

abstract：:A procedure is described to discover genes that are specifically expressed in human prostate. The procedure involves searching the expressed sequence tag (EST) database for genes that have many related EST sequences from human prostate cDNA libraries but none or few from nonprostate human libraries. The selected candi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasmatzis G,Essand M,Brinkmann U,Lee B,Pastan I

更新日期：1998-01-06 00:00:00

abstract：:In earlier papers L.W. introduced two sequences of higher-rank zeta functions associated to a smooth projective curve over a finite field, both of them generalizing the Artin zeta function of the curve. One of these zeta functions is defined geometrically in terms of semistable vector bundles of rank n over the curve ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weng L,Zagier D

更新日期：2020-03-24 00:00:00

abstract：:Phosphorylation plays a critical role in controlling the function of cytoskeletal assemblies but no direct method yet exists to measure the phosphorylation state of proteins at the level of individual molecules and assemblies. Herein, we apply scanning transmission electron microscopy in combination with electron ener...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leapman RD,Gallant PE,Reese TS,Andrews SB

更新日期：1997-07-22 00:00:00

abstract：:Mixed-metal oxides play a very important role in many areas of chemistry, physics, materials science, and geochemistry. Recently, there has been a strong interest in understanding phenomena associated with the deposition of oxide nanoparticles on the surface of a second (host) oxide. Here, scanning tunneling microscop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park JB,Graciani J,Evans J,Stacchiola D,Ma S,Liu P,Nambu A,Sanz JF,Hrbek J,Rodriguez JA

更新日期：2009-03-31 00:00:00

abstract：:Studies were undertaken to determine the applicability and effectiveness of immunoadsorption chromatography on anti-low density lipoprotein (LDL) columns as a plasma-cholesterol-lowering procedure. Mass production and isolation of monospecific antibodies against swine LDL (rho = 1.006-1.063 g/ml) was carried out by im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoffel W,Demant T

更新日期：1981-01-01 00:00:00

abstract：:Recent climate change has increased arctic soil temperatures and thawed large areas of permafrost, allowing for microbial respiration of previously frozen C. Furthermore, soil destabilization from melting ice has caused an increase in thermokarst failures that expose buried C and release dissolved organic C (DOC) to s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cory RM,Crump BC,Dobkowski JA,Kling GW

更新日期：2013-02-26 00:00:00

abstract：:Hebb proposed that neuronal cell assemblies are critical for effective perception, cognition, and action. However, evidence for brain mechanisms that coordinate multiple coactive assemblies remains lacking. Neuronal oscillations have been suggested as one possible mechanism for cell assembly coordination. Prior studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canolty RT,Ganguly K,Kennerley SW,Cadieu CF,Koepsell K,Wallis JD,Carmena JM

更新日期：2010-10-05 00:00:00

abstract：:The dominant theories of human placebo effects rely on a notion that consciously perceptible cues, such as verbal information or distinct stimuli in classical conditioning, provide signals that activate placebo effects. However, growing evidence suggest that behavior can be triggered by stimuli presented outside of co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jensen KB,Kaptchuk TJ,Kirsch I,Raicek J,Lindstrom KM,Berna C,Gollub RL,Ingvar M,Kong J

更新日期：2012-09-25 00:00:00

abstract：:Specific binding properties of the tritium-labeled delta opiate receptor agonist [3H][2-D-penicillamine, 5-D-penicillamine]enkephalin [( 3H][D-Pen2, D-Pen5]enkephalin) were characterized in the rat brain and in a mouse neuroblastoma-rat glioma hybrid cell line (NG 108-15). Saturation isotherms of [3H][D-Pen2, D-Pen5]e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama K,Gee KW,Mosberg HI,Hruby VJ,Yamamura HI

更新日期：1985-04-01 00:00:00

abstract：:Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If cell shape fluctuations are active enough, the aggregate sponta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marmottant P,Mgharbel A,Käfer J,Audren B,Rieu JP,Vial JC,van der Sanden B,Marée AF,Graner F,Delanoë-Ayari H

更新日期：2009-10-13 00:00:00

abstract：:Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1 protein that affect intracellular cholesterol trafficking and cause accumulation of unesterified cholesterol and other lipids in lysosomal storage organelles. We report the use of a series of small molecule histone deacetylase (HDAC) in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pipalia NH,Cosner CC,Huang A,Chatterjee A,Bourbon P,Farley N,Helquist P,Wiest O,Maxfield FR

更新日期：2011-04-05 00:00:00

abstract：:Signal transduction pathways activated by chemoattractants have been extensively studied, but little is known about the events mediating responses to mechanical stimuli. We discovered that acute mechanical perturbation of cells triggered transient activation of all tested components of the chemotactic signal transduct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Artemenko Y,Axiotakis L Jr,Borleis J,Iglesias PA,Devreotes PN

更新日期：2016-11-22 00:00:00

abstract：:Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells cultivated under steady-state conditions in a chemostat. The use of this sensitive and controlled system led to the detection of a rapid inhibition in the incorporation of (3-H)thymidine into cellular acid-precipitable material 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tovey M,Brouty-Boyé D,Gresser I

更新日期：1975-06-01 00:00:00

abstract：:We use stable isotope ratios in feces of wild mountain gorillas (Gorilla beringei) to test the hypothesis that diet shifts within a single year, as measured by dry mass intake, can be recovered. Isotopic separation of staple foods indicates that intraannual changes in the isotopic composition of feces reflect shifts i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumenthal SA,Chritz KL,Rothman JM,Cerling TE

更新日期：2012-12-26 00:00:00

abstract：:The spatial extent of the cortical filters selective for different spatial frequencies and orientations is limited. We studied psychophysically how information from the local filters is integrated into global pattern shapes, i.e., whether performance in the identification of a global pattern consisting of small, local...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saarinen J,Levi DM,Shen B

更新日期：1997-07-22 00:00:00

abstract：:Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have studied two host factors, the spleen and antibody, that influence sequest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： David PH,Hommel M,Miller LH,Udeinya IJ,Oligino LD

更新日期：1983-08-01 00:00:00

abstract：:Expression of the two X-linked loci glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) and hypoxanthine:guanine phosphoribosyltransferase (HGPRT; EC 2.4.2.8) was studied in single hair follicles of two females who were heterozygous for both of these genes (double heterozygotes). The coupling phase for these two loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein JL,Marks JF,Gartler SM

更新日期：1971-07-01 00:00:00

abstract：:The uncatalyzed reactions of O(2) (S = 1) with organic substrates (S = 0) are thermodynamically favorable but kinetically slow because they are spin-forbidden and the one-electron reduction potential of O(2) is unfavorable. In nature, many of these important O(2) reactions are catalyzed by metalloenzymes. In the case ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pau MY,Lipscomb JD,Solomon EI

更新日期：2007-11-20 00:00:00

abstract：:Genetic switches based on the [Formula: see text] system are master regulators of an array of cellular responses. Recent kinetic experiments have shown that [Formula: see text] can actively remove NF-κB bound to its genetic sites via a process called "molecular stripping." This allows the [Formula: see text] switch to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Potoyan DA,Zheng W,Komives EA,Wolynes PG

更新日期：2016-01-05 00:00:00

abstract：:Cortical networks that have been found to operate close to a critical point exhibit joint activations of large numbers of neurons. However, in motor cortex of the awake macaque monkey, we observe very different dynamics: massively parallel recordings of 155 single-neuron spiking activities show weak fluctuations on th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahmen D,Grün S,Diesmann M,Helias M

更新日期：2019-06-25 00:00:00

abstract：:Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the monkey, dog, and pig, by using an antiserum with equivalent sensitivities for detecting the octapeptide in free form or incorporated in the intact molecule. The failure to detect intact chole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Straus E,Yalow RS

更新日期：1978-01-01 00:00:00

abstract：:We demonstrate that poly(dA-dT) can adopt two conformations in solution, with the relative proportions dependent on the nature and concentration of the counter ion and cationic ligands. The synthetic DNA exhibits a dinucleotide repeat conformation on addition of CsF and Me4NCl at molar concentrations, with the NMR spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Kozlowski SA,Suggs JW,Cox SD

更新日期：1981-07-01 00:00:00

abstract：:The rearrangement of immunoglobulin genes in B-lymphocyte precursors requires the expression of the recombination activating genes (Rag), which leads to the generation of a highly diverse B-cell repertoire. We can use the level of Rag-1 mRNA in the bone marrow as an index of its capacity to support the maturation of B...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Yehuda A,Szabo P,Dyall R,Weksler ME

更新日期：1994-12-06 00:00:00

abstract：:After primary infection, human cytomegalovirus (HCMV) persists as a life-long latent infection, with host immunosuppression often resulting in clinical reactivation. During lytic infection, major changes in the expression of secreted cellular proteins (the secretome) occur that have profound effects on host-cell inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason GM,Poole E,Sissons JG,Wills MR,Sinclair JH

更新日期：2012-09-04 00:00:00

abstract：:Enkephalins, a group of small peptides with opiate-like activity, have been defined originally as neuropeptides. Recent reports showed, using in situ hybridization, that the enkephalin-encoding gene, proenkephalin A (pEnkA), is expressed in nondifferentiated cells of diverse mesodermal lineages. The transient expressi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosen H,Polakiewicz RD,Benzakine S,Bar-Shavit Z

更新日期：1991-05-01 00:00:00

abstract：:Alcoholism causes serious neurologic disease that may be due, in part, to the ability of ethanol to interact with neural cell membranes and change neuronal function. Adenosine receptors are membrane-bound proteins that appear to mediate some of the effects of ethanol in the brain. Human lymphocytes also have adenosine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diamond I,Wrubel B,Estrin W,Gordon A

更新日期：1987-03-01 00:00:00

abstract：:Activated transcription of the bacteriophage T4 late genes, which is coupled to concurrent DNA replication, is accomplished by an initiation complex containing the host RNA polymerase associated with two phage-encoded proteins, gp55 (the basal promoter specificity factor) and gp33 (the coactivator), as well as the DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Twist KA,Campbell EA,Deighan P,Nechaev S,Jain V,Geiduschek EP,Hochschild A,Darst SA

更新日期：2011-12-13 00:00:00

abstract：:Intracolonic administration of trinitrobenzene sulfonic acid in mice causes inflammation in the colon that is accompanied by increased expression of proinflammatory cytokines and of the substance P (SP), neurokinin 1 receptor (NK-1R) in the proximal mesenteric fat depot. We also investigated whether human mesenteric p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karagiannides I,Kokkotou E,Tansky M,Tchkonia T,Giorgadze N,O'Brien M,Leeman SE,Kirkland JL,Pothoulakis C

更新日期：2006-03-28 00:00:00

abstract：:The nicotinic acetylcholine (ACh) receptor (nAChR) plays a crucial role in excitatory neurotransmission and is an important target for drugs and insecticides. Diverse nAChR subtypes with various subunit combinations confer differential selectivity for nicotinic drugs. We investigated the subtype selectivity of nAChR a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomizawa M,Maltby D,Talley TT,Durkin KA,Medzihradszky KF,Burlingame AL,Taylor P,Casida JE

更新日期：2008-02-05 00:00:00

abstract：:We report the isolation and sequencing of cDNAs encoding two human glutamate decarboxylases (GADs; L-glutamate 1-carboxy-lyase, EC 4.1.1.15), GAD65 and GAD67. Human GAD65 cDNA encodes a Mr 65,000 polypeptide, with 585 amino acid residues, whereas human GAD67 encodes a Mr 67,000 polypeptide, with 594 amino acid residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bu DF,Erlander MG,Hitz BC,Tillakaratne NJ,Kaufman DL,Wagner-McPherson CB,Evans GA,Tobin AJ

更新日期：1992-03-15 00:00:00