Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis.

abstract：:Cell adhesion molecules (CAMs) may act as regulators of morphogenesis by constraining cell motion, forming borders, and controlling intercellular communications that lead to embryonic induction. This postulated causal role of CAMs in inductive events was tested here in an in vitro system of feather induction. In the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallin WJ,Chuong CM,Finkel LH,Edelman GM

更新日期：1986-11-01 00:00:00

abstract：:A species of Rhodopseudomonas that grows under strict anaerobic conditions in the dark and requires CO was isolated from lake and pond sediments. Although anaerobic growth in the dark occurs in a chemically defined mineral medium with CO as the only carbon and energy source, growth is stimulated by adding trypticase. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uffen RL

更新日期：1976-09-01 00:00:00

abstract：:We have isolated lentivirus strains that are related to the human immunodeficiency virus (HIV) from African green monkeys (Cercopithecus aethiops; AGM). Although immunologically related, these SIVagm are clearly distinct from other simian immunodeficiency virus (SIV) isolates, including isolates from Macaca mulatta (S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus G,Werner A,Baier M,Binniger D,Ferdinand FJ,Norley S,Kurth R

更新日期：1989-04-01 00:00:00

abstract：:It was reported that the rate of elongation of partially reconstituted RNA, if prepared without centrifugation, showed dependency upon the state of protein aggregation like that found when free RNA was used as the nucleic acid source [Butler, P. J. G. (1974) J. Mol. Biol. 82, 333-341]. Butler concluded from this resul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno T,Takahashi M,Okada Y

更新日期：1977-02-01 00:00:00

abstract：:The M2 protein of influenza A virus forms a transmembrane proton channel important for viral infection and replication. Amantadine blocks this channel, thus inhibiting viral replication. Elucidating the high-resolution structure of the M2 protein and its change upon amantadine binding is crucial for designing antivira...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cady SD,Hong M

更新日期：2008-02-05 00:00:00

abstract：:Developmental genetic studies of evolved differences in morphology have led to the hypothesis that cis-regulatory changes often underlie morphological evolution. However, because most of these studies focus on evolved loss of traits, the genetic architecture and possible association with cis-regulatory changes of gain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleves PA,Ellis NA,Jimenez MT,Nunez SM,Schluter D,Kingsley DM,Miller CT

更新日期：2014-09-23 00:00:00

abstract：:Repeated within-day testing on a texture discrimination task leads to retinotopically specific decreases in performance. Although perceptual learning has been shown to be highly specific to the retinotopic location and characteristics of the trained stimulus, the specificity of perceptual deterioration has not been st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mednick SC,Arman AC,Boynton GM

更新日期：2005-03-08 00:00:00

abstract：:Gene delivery to skeletal muscle is a promising strategy for the treatment of muscle disorders and for the systemic secretion of therapeutic proteins. However, present DNA delivery technologies have to be improved with regard to both the level of expression and interindividual variability. We report very efficient pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mir LM,Bureau MF,Gehl J,Rangara R,Rouy D,Caillaud JM,Delaere P,Branellec D,Schwartz B,Scherman D

更新日期：1999-04-13 00:00:00

abstract：:Integrin-dependent adhesions mediate reciprocal exchange of force and information between the cell and the extracellular matrix. These effects are attributed to the "focal adhesion clutch," in which moving actin filaments transmit force to integrins via dynamic protein interactions. To elucidate these processes, we me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Driscoll TP,Ahn SJ,Huang B,Kumar A,Schwartz MA

更新日期：2020-12-22 00:00:00

abstract：:A serum-free culture of dissociated neurons from embryonic rat hippocampus has been established as a rapid and quantitative in vitro test system for neurotrophic signals in the mammalian brain. By means of this cell culture bioassay, a novel low molecular weight neurotrophic factor (NTF) could be identified. NTF is es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller HW,Beckh S,Seifert W

更新日期：1984-02-01 00:00:00

abstract：:The Cdc28 protein kinase functions in the G1 to S phase transition of the cell cycle of the budding yeast Saccharomyces cerevisiae. This is in contrast with observations of the homologous protein kinase from a variety of metazoans, where activity and function are associated with the G2 to M phase transition. We presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed SI,Wittenberg C

更新日期：1990-08-01 00:00:00

abstract：:PDZ domains are abundant protein interaction modules and typically recognize a short motif at the C terminus of their ligands, with a few residues in the motif endowing the binding specificity. The sequence-based rules, however, cannot fully account for the specificity between the vast number of PDZ domains and ligand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pascoe HG,Gutowski S,Chen H,Brautigam CA,Chen Z,Sternweis PC,Zhang X

更新日期：2015-12-01 00:00:00

abstract：:Regulation of cardiac contraction by neurotransmitters and hormones is often correlated with regulation of the L-type Ca2(+)-channel current (ICa) through the opposite actions of two second messengers, cyclic AMP and cyclic GMP. While cyclic AMP stimulation of ICa is mediated by the activation of cyclic AMP-dependent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Méry PF,Lohmann SM,Walter U,Fischmeister R

更新日期：1991-02-15 00:00:00

abstract：:A fundamental mystery of plant cell biology is the occurrence of "stromules," stroma-filled tubular extensions from plastids (such as chloroplasts) that are universally observed in plants but whose functions are, in effect, completely unknown. One prevalent hypothesis is that stromules exchange signals or metabolites ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brunkard JO,Runkel AM,Zambryski PC

更新日期：2015-08-11 00:00:00

abstract：:The conversion of cells from a normal phenotype to full malignancy apparently requires multiple genetic events. Efforts to reconstruct multistep tumorigenesis in cell culture have shown that two types of oncogenes (typified by HRAS and MYC) can cooperate to elicit complete transformation. Transformation of embryonic r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hjelle B,Liu E,Bishop JM

更新日期：1988-06-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism that leads to excessive iron storage in the liver and other organs. Recently, between 83 and 100% of HH patients have been found to be homozygous for the same mutation in a novel major histocompatibility complex class I-like ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkkila S,Waheed A,Britton RS,Feder JN,Tsuchihashi Z,Schatzman RC,Bacon BR,Sly WS

更新日期：1997-03-18 00:00:00

abstract：:Previous studies have shown changes in membrane properties of neurons in rat deep cerebellar nuclei (DCN) as a function of development, but due to technical difficulties in obtaining viable DCN slices from adult animals, it remains unclear whether there are learning-related alterations in the membrane properties of DC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Smith-Bell CA,Burhans LB,O'Dell DE,Bell RW,Schreurs BG

更新日期：2018-10-02 00:00:00

abstract：:The C2 domain containing protein extended synaptotagmin (E-Syt) plays important roles in both lipid homeostasis and the intracellular signaling; however, its role in physiology remains largely unknown. Here, we show that hypothalamic E-Syt3 plays a critical role in diet-induced obesity (DIO). E-Syt3 is characteristica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Guan Y,Pan S,Yan L,Wang P,Chen Z,Shen Q,Zhao F,Zhang X,Li J,Li J,Cai D,Zhang G

更新日期：2020-08-18 00:00:00

abstract：:The primitive neurohypophyseal nonapeptide oxytocin (OXT) has established functions in parturition, lactation, appetite, and social behavior. We have shown that OXT has direct actions on the mammalian skeleton, stimulating bone formation by osteoblasts and modulating the genesis and function of bone-resorbing osteocla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun L,Lizneva D,Ji Y,Colaianni G,Hadelia E,Gumerova A,Ievleva K,Kuo TC,Korkmaz F,Ryu V,Rahimova A,Gera S,Taneja C,Khan A,Ahmad N,Tamma R,Bian Z,Zallone A,Kim SM,New MI,Iqbal J,Yuen T,Zaidi M

更新日期：2019-12-16 00:00:00

abstract：:The dynamics of social networks can determine the transmission of information, the spread of diseases, and the evolution of behavior. Despite this broad importance, a general framework for predicting social network stability has not been proposed. Here we present longitudinal data on the social dynamics of a cooperati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dakin R,Ryder TB

更新日期：2020-02-11 00:00:00

abstract：:Despite the importance of valuing another person's welfare for prosocial behavior, currently we have only a limited understanding of how these values are represented in the brain and, more importantly, how they give rise to individual variability in prosociality. In the present study, participants underwent functional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sul S,Tobler PN,Hein G,Leiberg S,Jung D,Fehr E,Kim H

更新日期：2015-06-23 00:00:00

abstract：:The present paper summarizes future needs in information and tools, technology, infrastructure, training, funding, and bioinformatics, to provide the genomic knowledge and tools for breeding and biotechnological goals in maize. The National Corn Genome Initiative (NCGA) has developed through actions taken by the Natio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coe EH

更新日期：1998-03-03 00:00:00

abstract：:One of the principles that has emerged from experimental evolutionary studies of microorganisms is that polymorphic alleles or new mutations can sometimes possess a latent potential to respond to selection in different environments, although the alleles may be functionally equivalent or disfavored under typical condit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stebbins GL,Hartl DL

更新日期：1988-07-01 00:00:00

abstract：:Shell shape and shell thickness of the intertidal snail Littorina obtusata changed markedly between 1871 and 1984 in northern New England. Shells collected prior to 1900 were high-spired with thin walls, whereas shells collected in 1982-84 were low-spired with thick walls. An intertidal crab (Carcinus maenas) which pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeley RH

更新日期：1986-09-01 00:00:00

abstract：:Efficient 3'-end processing of cell cycle-regulated mammalian histone premessenger RNAs (pre-mRNAs) requires an upstream stem-loop and a histone downstream element (HDE) that base pairs with the U7 small ribonucleoprotein. Insertions between these elements have two effects: the site of cleavage moves in concert with t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharl EC,Steitz JA

更新日期：1996-12-10 00:00:00

abstract：:Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still not fully understo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matecki S,Dridi H,Jung B,Saint N,Reiken SR,Scheuermann V,Mrozek S,Santulli G,Umanskaya A,Petrof BJ,Jaber S,Marks AR,Lacampagne A

更新日期：2016-08-09 00:00:00

abstract：:Ferredoxin was isolated from individual Leucaena glauca trees, and the distribution of amino acids at three of the four sites of sequence heterogeneity was determined. The results indicated that the most probable causes of the observed microheterogeneity are the presence of either nonallelic nuclear genes or differing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benson AM,Yasunobu KT

更新日期：1969-08-01 00:00:00

abstract：:The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agées) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in wome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazat L,Lafont S,Berr C,Debuire B,Tessier JF,Dartigues JF,Baulieu EE

更新日期：2001-07-03 00:00:00

abstract：:The functional groups found among the RNA bases and in the phosphoribose backbone represent a limited repertoire from which to construct a ribozyme active site. This work investigates the possibility that simple RNA phosphodiester and hydroxyl functional groups could catalyze amide bond synthesis. Reaction of amine gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chamberlin SI,Merino EJ,Weeks KM

更新日期：2002-11-12 00:00:00

abstract：:The techniques of electrophoresis were used in a search for evidence of mutation affecting protein structure, the indicators being hemoglobin and a set of serum proteins and erythrocyte enzymes. Among 94,796 locus tests on Amerindians from Central and South America, there was no evidence for mutation. Among 105,649 lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neel JV,Mohrenweiser HW,Meisler MH

更新日期：1980-10-01 00:00:00