The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.

abstract：:Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA methylation-based biomarkers of brain age: the epigenetic ageing rate and estimated proportion of neuron...

journal_title：Nature communications

authors： Lu AT,Hannon E,Levine ME,Crimmins EM,Lunnon K,Mill J,Geschwind DH,Horvath S

更新日期：2017-05-18 00:00:00

abstract：:With the rapidly growing global air traffic, the impacts of the black carbon (BC) in the aviation exhaust on climate, environment and public health are likely rising. The particle number and size distribution are crucial metrics for toxicological analysis and aerosol-cloud interactions. Here, a size-resolved BC partic...

journal_title：Nature communications

authors： Zhang X,Chen X,Wang J

更新日期：2019-02-01 00:00:00

abstract：:In certain regions of the predominantly nitrogen limited ocean, microbes can become co-limited by phosphorus. Within such regions, a proportion of the dissolved organic phosphorus pool can be accessed by microbes employing a variety of alkaline phosphatase (APase) enzymes. In contrast to the PhoA family of APases that...

journal_title：Nature communications

authors： Browning TJ,Achterberg EP,Yong JC,Rapp I,Utermann C,Engel A,Moore CM

更新日期：2017-05-19 00:00:00

abstract：:The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we add...

journal_title：Nature communications

authors： Fumagalli A,Heuninck J,Pizzoccaro A,Moutin E,Koenen J,Séveno M,Durroux T,Junier MP,Schlecht-Louf G,Bachelerie F,Schütz D,Stumm R,Smit MJ,Guérineau NC,Chaumont-Dubel S,Marin P

更新日期：2020-09-25 00:00:00

abstract：:Roughly a third (~30 ppm) of the carbon dioxide (CO2) that entered the ocean during ice ages is attributed to biological mechanisms. A leading hypothesis for the biological drawdown of CO2 is iron (Fe) fertilisation of the high latitudes, but modelling efforts attribute at most 10 ppm to this mechanism, leaving ~20 pp...

journal_title：Nature communications

authors： Buchanan PJ,Chase Z,Matear RJ,Phipps SJ,Bindoff NL

更新日期：2019-10-10 00:00:00

abstract：:Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of cochaperones. Here, we demonstrate that gp96 chaperones multiple Toll-like receptors (TLRs), but not TLR3, in...

journal_title：Nature communications

authors： Liu B,Yang Y,Qiu Z,Staron M,Hong F,Li Y,Wu S,Li Y,Hao B,Bona R,Han D,Li Z

更新日期：2010-09-21 00:00:00

abstract：:Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from a profound loss in proteostasis, which sensitize...

journal_title：Nature communications

authors： Vermulst M,Denney AS,Lang MJ,Hung CW,Moore S,Moseley MA,Thompson JW,Madden V,Gauer J,Wolfe KJ,Summers DW,Schleit J,Sutphin GL,Haroon S,Holczbauer A,Caine J,Jorgenson J,Cyr D,Kaeberlein M,Strathern JN,Duncan MC,E

更新日期：2015-08-25 00:00:00

abstract：:Marine low clouds play an important role in the climate system, and their properties are sensitive to cloud condensation nuclei concentrations. While new particle formation represents a major source of cloud condensation nuclei globally, the prevailing view is that new particle formation rarely occurs in remote marine...

journal_title：Nature communications

authors： Zheng G,Wang Y,Wood R,Jensen MP,Kuang C,McCoy IL,Matthews A,Mei F,Tomlinson JM,Shilling JE,Zawadowicz MA,Crosbie E,Moore R,Ziemba L,Andreae MO,Wang J

更新日期：2021-01-22 00:00:00

abstract：:Inorganic perovskites such as CsPbX3 (X=Cl, Br, I) have attracted attention due to their excellent thermal stability and high photoluminescence quantum efficiency. However, the electroluminescence quantum efficiency of their light-emitting diodes was <1%. We posited that this low efficiency was a result of high leakag...

journal_title：Nature communications

authors： Zhang L,Yang X,Jiang Q,Wang P,Yin Z,Zhang X,Tan H,Yang YM,Wei M,Sutherland BR,Sargent EH,You J

更新日期：2017-06-07 00:00:00

abstract：:Broomcorn millet (Panicum miliaceum L.) is the most water-efficient cereal and one of the earliest domesticated plants. Here we report its high-quality, chromosome-scale genome assembly using a combination of short-read sequencing, single-molecule real-time sequencing, Hi-C, and a high-density genetic map. Phylogeneti...

journal_title：Nature communications

authors： Zou C,Li L,Miki D,Li D,Tang Q,Xiao L,Rajput S,Deng P,Peng L,Jia W,Huang R,Zhang M,Sun Y,Hu J,Fu X,Schnable PS,Chang Y,Li F,Zhang H,Feng B,Zhu X,Liu R,Schnable JC,Zhu JK,Zhang H

更新日期：2019-01-25 00:00:00

abstract：:Many bacteria can exchange genetic material through horizontal gene transfer (HGT) mediated by plasmids and plasmid-borne transposable elements. Here, we study the population structure and dynamics of over 10,000 bacterial plasmids, by quantifying their genetic similarities and reconstructing a network based on their ...

journal_title：Nature communications

authors： Acman M,van Dorp L,Santini JM,Balloux F

更新日期：2020-05-15 00:00:00

abstract：:Cardiac voltage-gated sodium channels (Nav1.5) play an essential role in regulating cardiac electric activity by initiating and propagating action potentials in the heart. Altered Nav1.5 function is associated with multiple cardiac diseases including long-QT3 and Brugada syndrome. Here, we show that Nav1.5 is subject ...

journal_title：Nature communications

authors： Pei Z,Xiao Y,Meng J,Hudmon A,Cummins TR

更新日期：2016-06-23 00:00:00

abstract：:The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and m...

journal_title：Nature communications

authors： Ding J,Chen K,Liu H,Huang L,Chen Y,Lv Y,Yang Q,Guo Q,Han Z,Lambon Ralph MA

更新日期：2020-05-22 00:00:00

abstract：:Ultrasound sensors have wide applications across science and technology. However, improved sensitivity is required for both miniaturisation and increased spatial resolution. Here, we introduce cavity optomechanical ultrasound sensing, where dual optical and mechanical resonances enhance the ultrasound signal. We achie...

journal_title：Nature communications

authors： Basiri-Esfahani S,Armin A,Forstner S,Bowen WP

更新日期：2019-01-10 00:00:00

abstract：:Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies depends on the degree to which initially injured axons can reco...

journal_title：Nature communications

authors： Williams PR,Marincu BN,Sorbara CD,Mahler CF,Schumacher AM,Griesbeck O,Kerschensteiner M,Misgeld T

更新日期：2014-12-16 00:00:00

abstract：:Observational studies have reported inconsistent associations between circulating lipids and breast cancer risk. Using results from >400,000 participants in two-sample Mendelian randomization, we show that genetically raised LDL-cholesterol is associated with higher risk of breast cancer (odds ratio, OR, per standard ...

journal_title：Nature communications

authors： Nowak C,Ärnlöv J

更新日期：2018-09-27 00:00:00

abstract：:A key question in materials science is how fast properties evolve, which relates to the kinetics of phase transformations. In metals, kinetics is primarily connected to diffusion, which for substitutional elements is enabled via mobile atomic-lattice vacancies. In fact, non-equilibrium vacancies are often required for...

journal_title：Nature communications

authors： Dumitraschkewitz P,Uggowitzer PJ,Gerstl SSA,Löffler JF,Pogatscher S

更新日期：2019-10-18 00:00:00

abstract：:Neurodegenerative lesions induce sprouting of new collaterals from surviving axons, but the extent to which this form of axonal remodelling alters brain functional structure remains unclear. To understand how collateral sprouting proceeds in the adult brain, we imaged post-lesion sprouting of cerebellar climbing fibre...

journal_title：Nature communications

authors： Dhar M,Brenner JM,Sakimura K,Kano M,Nishiyama H

更新日期：2016-09-21 00:00:00

abstract：:Alcohol oxidation reactions are widely used for the preparation of aldehydes and ketones. The electrolysis of alcohols to carbonyl compounds have been underutilized owing to low efficiency. Herein, we report an electrochemical oxidation of various alcohols in a continuous-flow reactor without external oxidants, base o...

journal_title：Nature communications

authors： Wang D,Wang P,Wang S,Chen YH,Zhang H,Lei A

更新日期：2019-06-26 00:00:00

abstract：:Because the surface-to-volume ratio of quasi-two-dimensional materials is extremely high, understanding their surface characteristics is crucial for practically controlling their intrinsic properties and fabricating p-type and n-type layered semiconductors. Van der Waals crystals are expected to have an inert surface ...

journal_title：Nature communications

authors： Siao MD,Shen WC,Chen RS,Chang ZW,Shih MC,Chiu YP,Cheng CM

更新日期：2018-04-12 00:00:00

abstract：:We present Biomedisa, a free and easy-to-use open-source online platform developed for semi-automatic segmentation of large volumetric images. The segmentation is based on a smart interpolation of sparsely pre-segmented slices taking into account the complete underlying image data. Biomedisa is particularly valuable w...

journal_title：Nature communications

authors： Lösel PD,van de Kamp T,Jayme A,Ershov A,Faragó T,Pichler O,Tan Jerome N,Aadepu N,Bremer S,Chilingaryan SA,Heethoff M,Kopmann A,Odar J,Schmelzle S,Zuber M,Wittbrodt J,Baumbach T,Heuveline V

更新日期：2020-11-04 00:00:00

abstract：:Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...

journal_title：Nature communications

authors： Caires-Júnior LC,Goulart E,Melo US,Araujo BHS,Alvizi L,Soares-Schanoski A,de Oliveira DF,Kobayashi GS,Griesi-Oliveira K,Musso CM,Amaral MS,daSilva LF,Astray RM,Suárez-Patiño SF,Ventini DC,Gomes da Silva S,Yamamoto GL,Ez

更新日期：2018-02-02 00:00:00

abstract：:Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...

journal_title：Nature communications

authors： Shi Z,Miao C,Schoepf UJ,Savage RH,Dargis DM,Pan C,Chai X,Li XL,Xia S,Zhang X,Gu Y,Zhang Y,Hu B,Xu W,Zhou C,Luo S,Wang H,Mao L,Liang K,Wen L,Zhou L,Yu Y,Lu GM,Zhang LJ

更新日期：2020-11-30 00:00:00

abstract：:Carbon coating is a simple, effective and common technique for improving the conductivity of active materials in lithium ion batteries. However, carbon coating provides a strong reducing atmosphere and many factors remain unclear concerning the interface nature and underlying interaction mechanism that occurs between ...

journal_title：Nature communications

authors： Wang J,Yang J,Tang Y,Liu J,Zhang Y,Liang G,Gauthier M,Chen-Wiegart YC,Norouzi Banis M,Li X,Li R,Wang J,Sham TK,Sun X

更新日期：2014-03-05 00:00:00

abstract：:We report the results from the first 5D tomographic diffraction imaging experiment of a complex Ni-Pd/CeO2-ZrO2/Al2O3 catalyst used for methane reforming. This five-dimensional (three spatial, one scattering and one dimension to denote time/imposed state) approach enabled us to track the chemical evolution of many par...

journal_title：Nature communications

authors： Vamvakeros A,Jacques SDM,Di Michiel M,Matras D,Middelkoop V,Ismagilov IZ,Matus EV,Kuznetsov VV,Drnec J,Senecal P,Beale AM

更新日期：2018-11-12 00:00:00

abstract：:The nucleotidyl cyclase toxin ExoY is one of the virulence factors injected by the Pseudomonas aeruginosa type III secretion system into host cells. Inside cells, it is activated by an unknown eukaryotic cofactor to synthesize various cyclic nucleotide monophosphates. ExoY-like adenylate cyclases are also found in Mul...

journal_title：Nature communications

authors： Belyy A,Raoux-Barbot D,Saveanu C,Namane A,Ogryzko V,Worpenberg L,David V,Henriot V,Fellous S,Merrifield C,Assayag E,Ladant D,Renault L,Mechold U

更新日期：2016-12-05 00:00:00

abstract：:ASXL2 is frequently mutated in acute myeloid leukaemia patients with t(8;21). However, the roles of ASXL2 in normal haematopoiesis and the pathogenesis of myeloid malignancies remain unknown. Here we show that deletion of Asxl2 in mice leads to the development of myelodysplastic syndrome (MDS)-like disease. Asxl2-/- m...

journal_title：Nature communications

authors： Li J,He F,Zhang P,Chen S,Shi H,Sun Y,Guo Y,Yang H,Man N,Greenblatt S,Li Z,Guo Z,Zhou Y,Wang L,Morey L,Williams S,Chen X,Wang QT,Nimer SD,Yu P,Wang QF,Xu M,Yang FC

更新日期：2017-06-08 00:00:00

abstract：:Nano-ordered intermetallic compounds have generated great interest in fuel cell applications. However, the synthesis of non-preciousearly transition metal intermetallic nanoparticles remains a formidable challenge owing to the extremely oxyphilic nature and very negative reduction potentials. Here, we have successfull...

journal_title：Nature communications

authors： Feng G,An L,Li B,Zuo Y,Song J,Ning F,Jiang N,Cheng X,Zhang Y,Xia D

更新日期：2019-10-04 00:00:00

abstract：:Doping is a primary tool for the modification of the properties of materials. Occlusion of guest molecules in crystals generally reduces their symmetry by the creation of polar domains, which engender polarization and pyroelectricity in the doped crystals. Here we describe a molecular-level determination of the struct...

journal_title：Nature communications

authors： Meirzadeh E,Azuri I,Qi Y,Ehre D,Rappe AM,Lahav M,Kronik L,Lubomirsky I

更新日期：2016-11-08 00:00:00

abstract：:Insight into crumpling or compaction of one-dimensional objects is important for understanding biopolymer packaging and designing innovative technological devices. By compacting various types of wires in rigid confinements and characterizing the morphology of the resulting crumpled structures, here, we report how fric...

journal_title：Nature communications

authors： Shaebani MR,Najafi J,Farnudi A,Bonn D,Habibi M

更新日期：2017-06-06 00:00:00