Abstract:
:DNA methylation is an epigenetic modification that is generally associated with repression of transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent high-throughput genomic and proteomic screenings, DNA methylation can also have different outcomes, including activation of transcription. This is evidenced by the fact that transcription factors can interact with methylated DNA sequences. Furthermore, in certain cellular contexts, genes containing methylated promoters are highly transcribed. Interestingly, this uncoupling between methylated DNA and repression of transcription seems to be particularly evident in germ cells and pluripotent cells. Thus, contrary to previous assumptions, DNA methylation is not exclusively associated with repression of transcription initiation.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Spruijt CG,Vermeulen Mdoi
10.1038/nsmb.2910subject
Has Abstractpub_date
2014-11-01 00:00:00pages
949-54issue
11eissn
1545-9993issn
1545-9985pii
nsmb.2910journal_volume
21pub_type
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