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The stalk region of dynamin drives the constriction of dynamin tubes.

Abstract：

:The GTPase dynamin is essential for numerous vesiculation events including clathrin-mediated endocytosis. Upon GTP hydrolysis, dynamin constricts a lipid bilayer. Previously, a three-dimensional structure of mutant dynamin in the constricted state was determined by helical reconstruction methods. We solved the nonconstricted state by a single-particle approach and show that the stalk region of dynamin undergoes a large conformational change that drives tube constriction.

journal_name

Nat Struct Mol Biol

journal_title

Nature structural & molecular biology

authors

Chen YJ,Zhang P,Egelman EH,Hinshaw JE

doi

10.1038/nsmb762

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

574-5

issue

6

eissn

1545-9993

issn

1545-9985

pii

nsmb762

journal_volume

11

pub_type

杂志文章

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