Abstract：
:Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to DNA, and chemical modification of histones is a major means by which the cell modulates nucleosome mobility and turnover. Histone modifications are linked to essentially every cellular process requiring DNA access, including transcription, replication and repair. Here we consider properties of the major types of histone modification in the context of their associated biological processes to view them in light of the cellular mechanisms that regulate nucleosome dynamics.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Zentner GE,Henikoff Sdoi
10.1038/nsmb.2470subject
Has Abstractpub_date
2013-03-01 00:00:00pages
259-66issue
3eissn
1545-9993issn
1545-9985pii
nsmb.2470journal_volume
20pub_type
杂志文章,评审abstract：:When targeting promoter regions, small interfering RNAs (siRNAs) trigger a previously proposed pathway known as transcriptional gene silencing by promoting heterochromatin formation. Here we show that siRNAs targeting intronic or exonic sequences close to an alternative exon regulate the splicing of that exon. The eff...
journal_title：Nature structural & molecular biology
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb1042
更新日期：2006-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Nature structural & molecular biology
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doi：10.1038/nsmb.2796
更新日期：2014-04-01 00:00:00
abstract：: ...
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更新日期：2018-12-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2011-06-19 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
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更新日期：2006-03-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
abstract：:The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often lethal respiratory illness in humans, and no vaccines or specific treatments are available. Infections are initiated via binding of the MERS-CoV spike (S) glycoprotein to sialosides and dipeptidyl-peptidase 4 (the attachment and entry ...
journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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更新日期：2007-12-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.2204
更新日期：2012-01-15 00:00:00
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journal_title：Nature structural & molecular biology
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.3272
更新日期：2016-09-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1038/nsmb852
更新日期：2004-11-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.1738
更新日期：2010-01-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
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更新日期：2006-11-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
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journal_title：Nature structural & molecular biology
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更新日期：2020-03-01 00:00:00
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journal_title：Nature structural & molecular biology
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更新日期：2017-12-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2005-08-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章,评审
doi：10.1038/nsmb.1450
更新日期：2008-07-01 00:00:00
abstract：:The asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a) acts as a repressive mark that antagonizes trimethylation of H3 lysine 4. Here we report that H3R2 is also symmetrically dimethylated (H3R2me2s) by PRMT5 and PRMT7 and present in euchromatic regions. Profiling of H3-tail interactors by SILAC MS revealed ...
journal_title：Nature structural & molecular biology
pub_type： 杂志文章
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更新日期：2012-01-08 00:00:00
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journal_title：Nature structural & molecular biology
pub_type： 杂志文章,评审
doi：10.1038/nsmb.3147
更新日期：2016-01-01 00:00:00
abstract：:Complex forms of cellular motility, including cell division, organelle trafficking or signal amplification in the auditory system, require strong coordination of the myosin motors involved. The most basic mechanism of coordination is via direct mechanical interactions of individual motor heads leading to modification ...
journal_title：Nature structural & molecular biology
pub_type： 杂志文章
doi：10.1038/nsmb.1820
更新日期：2010-05-01 00:00:00
